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Life
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Recent Developments in Movement Disorders
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Recent Developments in Movement Disorders

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (29 March 2024) | Viewed by 4648

Special Issue Editors

Dr. Ryoma Morigaki

E-Mail Website
Guest Editor
Department of Advanced Brain Research, Institute of Biomedical Sciences, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan
Interests: basal ganglia; striatum; striosome and matrix; deep brain stimulation; Parkinson’s disease; dystonia
Special Issues, Collections and Topics in MDPI journals
Dr. Hideo Mure

E-Mail Website
Guest Editor
Center for Neuromodulation, Kurashiki Heisei Hospital, Okayama 710-0826, Japan
Interests: deep brain stimulation; spinal cord stimulation; focused ultrasound surgery; functional neuroimaging

Special Issue Information

Dear Colleagues,

Movement disorders pose significant challenges in clinical management, with conditions such as Parkinson's disease/syndrome, dystonia and tremors. Despite substantial efforts, the precise etiology of movement disorders remains elusive. Nonetheless, recent developments in clinical interventions have led to notable improvements, facilitating the identification of the underlying mechanisms. This Special Issue aspires to compile comprehensive review articles and pioneering research investigations to elucidate recent developments in movement disorders. By assessing the current state of our understanding, this collection seeks to propel future advancements in treatment strategies.

Dr. Ryoma Morigaki
Dr. Hideo Mure
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • movement disorders
  • dystonia
  • Parkinson’s disease
  • Parkinsonian disorder
  • tremor
  • tics
  • chorea
  • dyskinesias
  • Huntington’s disease
  • diagnosis
  • treatment
  • deep brain stimulation
  • neuromodulation
  • neurotransmitter
  • biomarkers

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Published Papers (2 papers)

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Research

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13 pages, 559 KiB  
Article
Early Intervention Guided by the General Movements Examination at Term Corrected Age—Short Term Outcomes
by Adrian Ioan Toma, Vlad Dima, Adelina Alexe, Cristina Bojan, Alexandra Floriana Nemeș, Bogdan Florin Gonț, Alexandra Arghirescu, Andreea Ioana Necula, Alina Fieraru, Roxana Stoiciu, Andrada Mirea, Andreea Calomfirescu Avramescu and Al Jashi Isam
Life 2024, 14(4), 480; https://doi.org/10.3390/life14040480 - 5 Apr 2024
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Abstract
Background and aim: The early identification of the former premature neonates at risk of neurologic sequelae could lead to early intervention and a better prognosis. This pilot study aimed to investigate whether the General Movement patterns observed at term-equivalent age in former premature [...] Read more.
Background and aim: The early identification of the former premature neonates at risk of neurologic sequelae could lead to early intervention and a better prognosis. This pilot study aimed to investigate whether the General Movement patterns observed at term-equivalent age in former premature infants could serve as predictors for guiding early intervention and improving prognosis. Materials and methods: In a population of 44 premature neonates (mean gestational age 33.59 weeks (+2.43 weeks)) examined at term-equivalent age, 10 neonates with a cramped–synchronized General Movements motor pattern were identified. These neonates were included in an early intervention program consisting of physiotherapy executed both by the therapist and by the parents at home. They were again examined at a corrected age of 12 weeks. The presence or absence of fidgety movements and the MOS-R (motor optimality score revised) was noted. The examinations were performed by certified specialists. Results: Normal fidgety movements and a MOS-R of 20–24 were presented in 9/10 of the former premature infants, with normal foot to foot contact present in 7/10, and normal hand to hand contact present in 5/10. The atypical patterns noted were side to side movements of the head in 5/10, a non-centered head in 9/10, asymmetric tonic neck reflex in 9/10 and jerky movements in 10/10. One patient presented with no fidgety movements and a MOS-R score of 9. Conclusion: Early intervention in our group of patients allowed for an improvement in the neurologic status, demonstrated by the presence of fidgety movements. We suggest that early intervention should be indicated in all premature infants that present with a cramped–synchronized GM pattern during examination at term-equivalent age. However, due to the small sample size, the absence of statistical analysis and a control group, and the limited follow-up period, the conclusions must be approached with caution. Full article
(This article belongs to the Special Issue Recent Developments in Movement Disorders)
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Review

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13 pages, 595 KiB  
Review
Beta–Gamma Phase-Amplitude Coupling as a Non-Invasive Biomarker for Parkinson’s Disease: Insights from Electroencephalography Studies
by Tisa Hodnik, Stiven Roytman, Nico I. Bohnen and Uros Marusic
Life 2024, 14(3), 391; https://doi.org/10.3390/life14030391 - 15 Mar 2024
Viewed by 2259
Abstract
Phase-amplitude coupling (PAC) describes the interaction of two separate frequencies in which the lower frequency phase acts as a carrier frequency of the higher frequency amplitude. It is a means of carrying integrated streams of information between micro- and macroscale systems in the [...] Read more.
Phase-amplitude coupling (PAC) describes the interaction of two separate frequencies in which the lower frequency phase acts as a carrier frequency of the higher frequency amplitude. It is a means of carrying integrated streams of information between micro- and macroscale systems in the brain, allowing for coordinated activity of separate brain regions. A beta–gamma PAC increase over the sensorimotor cortex has been observed consistently in people with Parkinson’s disease (PD). Its cause is attributed to neural entrainment in the basal ganglia, caused by pathological degeneration characteristic of PD. Disruptions in this phenomenon in PD patients have been observed in the resting state as well as during movement recordings and have reliably distinguished patients from healthy participants. The changes can be detected non-invasively with the electroencephalogram (EEG). They correspond to the severity of the motor symptoms and the medication status of people with PD. Furthermore, a medication-induced decrease in PAC in PD correlates with the alleviation of motor symptoms measured by assessment scales. A beta–gamma PAC increase has, therefore, been explored as a possible means of quantifying motor pathology in PD. The application of this parameter to closed-loop deep brain stimulation could serve as a self-adaptation measure of such treatment, responding to fluctuations of motor symptom severity in PD. Furthermore, phase-dependent stimulation provides a new precise method for modulating PAC increases in the cortex. This review offers a comprehensive synthesis of the current EEG-based evidence on PAC fluctuations in PD, explores the potential practical utility of this biomarker, and provides recommendations for future research. Full article
(This article belongs to the Special Issue Recent Developments in Movement Disorders)
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