Feature Studies in Respiratory Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4349

Special Issue Editors


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Guest Editor
Institute of Translational Pharmacology, Italian National Research Council (CNR), Rome, Italy
Interests: inflammatory airway diseases; air pollution; smoke; allergy; inflammation; oxidative stress; bronchial and nasal epithelial cells; 3D models
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Traslational Pharmacology, Italian National Research Council (CNR), Rome, Italy
Interests: inflammatory airway diseases; allergy; inflammation; oxidative stress; smoke; air pollution; bronchial and nasal epithelial cells; 3D models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical research is multidisciplinary and often uses integrated approaches that create different experimental models with complementary functions. This approach is important to understand the physiological and pathophysiological mechanisms of respiratory diseases.

Susceptibility to the pathogenesis of most lung diseases derives from a complex interaction between the lung, environment, genetic background, and the nature of host responses.

Inflammation in the lung is the body's natural response to injury. It works to remove harmful stimuli such as pathogens, irritants and damaged cells and initiate the healing process. Acute and chronic lung inflammation is seen in several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF), and other respiratory diseases.

Unfortunately, all pharmacological strategies used in respiratory diseases are aimed at suppressing inflammation and resolving bronchodilation, but no treatment is dedicated to eradicating the disease. Therefore, understanding the pathophysiological systems of the lung is crucial for the development of new therapeutic approaches. Therefore, the aims of this Special issue are to examine the pathophysiological mechanisms and processes and to identify new pharmacological treatments for preventing or treating the respiratory diseases.

Dr. Giusy Daniela Albano
Dr. Mirella Profita
Guest Editors

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Keywords

  • inflammatory airway diseases
  • air pollution
  • smoke
  • allergy
  • inflammation
  • oxidative stress
  • bronchial and nasal epithelial cells
  • 3D models
  • system biology
  • pharmacological treatments

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Published Papers (2 papers)

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Review

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16 pages, 590 KiB  
Review
The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature
by Cristiana Indolfi, Elisabetta D’Addio, Chiara Lucia Bencivenga, Giulio Rivetti, Irene Bettini, Amelia Licari, Sara Manti, Francesca Mori, Michele Miraglia del Giudice and Angela Klain
Life 2023, 13(9), 1859; https://doi.org/10.3390/life13091859 - 2 Sep 2023
Cited by 2 | Viewed by 2699
Abstract
The current literature shows mixed results relating to the significance of environmental exposure, such as owning a pet, and the development of atopy in children. Our review aimed to collect the most recent evidence on the association between early-life cat and dog ownership [...] Read more.
The current literature shows mixed results relating to the significance of environmental exposure, such as owning a pet, and the development of atopy in children. Our review aimed to collect the most recent evidence on the association between early-life cat and dog ownership and the development of allergy and asthma. A comprehensive literature review was performed using PubMed and Scopus. The search included the main keywords of our PICO: (((early exposure) AND (children) AND (allergy)) OR (asthma)) AND (dog) OR (cat). Randomized controlled trials (RCTs), case–control studies, clinical trials, meta-analyses, and systematic reviews of children within the last five years (2018–2023) were searched and included. During the search process, 52 articles from PubMed and 43 from Scopus were found. A total of 17 articles were deemed to be suitable and included. Fairly consistent results regarding early exposure to pets, in particular dogs, and the prevention of food allergies have been described. Furthermore, there seems to be a protective effect against allergy and asthma in relation to the number of pets owned. The likelihood of a child developing allergy and asthma seems to be influenced by various factors, including the child’s genetic background and early exposure to different environmental factors, including allergens that may interact with the gut microbiota and immune system. Full article
(This article belongs to the Special Issue Feature Studies in Respiratory Diseases)
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9 pages, 2237 KiB  
Case Report
Large Lung Consolidation: A Rare Presentation of Pulmonary Sarcoidosis
by Monica Steluta Marc, Camelia Corina Pescaru, Emanuela Oana Costin, Alexandru Florian Crisan, Adelina Maritescu, Andrei Pescaru, Noemi Suppini, Gheorghe Emilian Olteanu, Daniel Traila, Cristian Oancea and Diana Manolescu
Life 2024, 14(1), 44; https://doi.org/10.3390/life14010044 - 27 Dec 2023
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Abstract
Sarcoidosis is a complex inflammatory disease of uncertain origin, characterized by non-necrotizing epithelioid cell granulomas (NNEGs) affecting multiple organ systems. Although many different clinical and pathological phenotypes can be present, with different organs involved, the lung is the most common site described. In [...] Read more.
Sarcoidosis is a complex inflammatory disease of uncertain origin, characterized by non-necrotizing epithelioid cell granulomas (NNEGs) affecting multiple organ systems. Although many different clinical and pathological phenotypes can be present, with different organs involved, the lung is the most common site described. In this case report, we (a) present and discuss the broad differential diagnosis of a patient presenting with a solitary lung mass with clinical and imaging features of lung cancer that ultimately was confirmed with a rare manifestation of stage II pulmonary sarcoidosis, and (b) analyze and compare similar cases from the literature. Full article
(This article belongs to the Special Issue Feature Studies in Respiratory Diseases)
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