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Journals
Biomolecules
Special Issues
Airway Diseases: Molecular Updates and Perspectives
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Airway Diseases: Molecular Updates and Perspectives

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1072

Special Issue Editor

Dr. Giusy Daniela Albano

E-Mail Website
Guest Editor
Institute of Translational Pharmacology, Italian National Research Council (CNR), Rome, Italy
Interests: inflammatory airway diseases; air pollution; smoke; allergy; inflammation; oxidative stress; bronchial and nasal epithelial cells; 3D models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Airway diseases are highly prevalent worldwide. Although, these diseases present several common characteristics, they have different clinical outcomes. Airway diseases are characterized as lung tissue disorders and respiratory dysfunctions, including asthma, chronic obstructive pulmonary disease (COPD), pneumonia and tuberculosis, lung cancer, pulmonary hypertension, pulmonary fibrosis, and many other respiratory diseases.

The cause of most respiratory diseases is smoking, infections, allergies, pollution, and genetic mutations. Unfortunately, many mechanisms involved in pathogenesis are not known.

At this moment, many pharmacological and therapeutic treatments are not completely effective. Therefore, it is necessary to identify the molecular mechanisms underlying respiratory diseases and to develop new drugs.

This Special Issue aims to identify and promote the recent advances in the field of molecular mechanisms, novel drugs, therapeutic approaches, and new models to study the pathophysiology underlying respiratory diseases.

Dr. Giusy Daniela Albano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • airway disease
  • molecular mechanisms
  • drugs
  • models

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Published Papers (1 paper)

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Research

17 pages, 879 KiB  
Article
Identification of Exhaled Metabolites Correlated with Respiratory Function and Clinical Features in Adult Patients with Cystic Fibrosis by Real-Time Proton Mass Spectrometry
by Malika Mustafina, Artemiy Silantyev, Stanislav Krasovskiy, Alexander Chernyak, Zhanna Naumenko, Aleksandr Suvorov, Daria Gognieva, Magomed Abdullaev, Olga Suvorova, Anna Schmidt, Aida Gadzhiakhmedova, Aleksandra Bykova, Sergey Avdeev, Vladimir Betelin, Abram Syrkin and Philipp Kopylov
Biomolecules 2024, 14(9), 1189; https://doi.org/10.3390/biom14091189 - 21 Sep 2024
Viewed by 778
Abstract
Cystic fibrosis (CF) is a hereditary disease characterized by the progression of respiratory disorders, especially in adult patients. The purpose of the study was to identify volatile organic compounds (VOCs) as predictors of respiratory dysfunction, chronic respiratory infections of Staphylococcus aureus, Pseudomonas [...] Read more.
Cystic fibrosis (CF) is a hereditary disease characterized by the progression of respiratory disorders, especially in adult patients. The purpose of the study was to identify volatile organic compounds (VOCs) as predictors of respiratory dysfunction, chronic respiratory infections of Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia, and VOCs associated with severe genotype and highly effective modulator treatment (HEMT). Exhaled breath samples from 102 adults with CF were analyzed using PTR-TOF-MS, obtained during a forced expiratory maneuver and normal quiet breathing. Using cross-validation and building gradient boosting classifiers (XGBoost), the importance of VOCs for functional and clinical outcomes was determined. The presence of the previously identified VOCs indole, phenol, and dimethyl sulfide were metabolic outcomes associated with impaired respiratory function. New VOCs associated with respiratory disorders were methyl acetate, carbamic acid, 1,3-Pentadiene, and 2,3-dimethyl-2-butene; VOCs associated with the above mentioned respiratory pathogens were non-differentiable nitrogen-containing organic compounds m/z = 47.041 (CH5NO)+ and m/z = 44.044 (C2H5NH+), hydrocarbons (cyclopropane, propene) and methanethiol; and VOCs associated with severe CFTR genotype were non-differentiable VOC m/z = 281.053. No significant features associated with the use of HEMT were identified. Early non-invasive determination of VOCs as biomarkers of the severity of CF and specific pathogenic respiratory flora could make it possible to prescribe adequate therapy and assess the prognosis of the disease. However, further larger standardized studies are needed for clinical use. Full article
(This article belongs to the Special Issue Airway Diseases: Molecular Updates and Perspectives)
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