Pancreatic Cancer: Long Survivals
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1927
Special Issue Editors
Interests: pancreatic cancer; biomarker; neoadjuvant therapy; target therapy
Interests: pancreatic cancer; biomarker; neoadjuvant therapy; target therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult tumors to treat. Radical surgery is the only potentially curative treatment; however, even in the group of radically resected patients, the five-year survival rate is below 25%. There are several reasons for the dismal prognosis of PDAC, particularly the late onset of symptoms, biological aggressiveness characterized by early metastasis and impressive resistance to many anticancer agents.
Unfortunately, progress in the management of both resectable and borderline-resectable PDAC, but especially of locally advanced/metastatic disease has been very modest in the last decades. In fact, chemotherapy regimens (gemcitabine and abraxane or FOLFIRINOX) are considered the gold standard in the treatment of locally advanced or metastatic PDAC, though providing only slight improvements in the overall survival, reaching few months at best. No target therapies or immunotherapy approaches are nowadays clearly effective for PDAC. Additionally, no predictive biomarkers of treatment effectiveness are used routinely in clinical practice. Only the implementation of genetic testing can change a very narrow treatment landscape for small subsets of patients with actionable aberrations. In particular, in BRCA1/2-mutated patients, olaparib (PARP inhibitor) may be proposed as a maintenance strategy. Nevertheless, the differences in outcomes of PDAC patients exist. Therefore, understanding the characteristics of long pancreatic cancer survivals may be clinically important.
Dr. Francesco Leonardi
Dr. Ingrid Garajova
Guest Editors
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Keywords
- pancreatic cancer
- long survival
- outcome
- pancreatic adenocarcinoma
- long-term survival
- surgical resection
- chemotherapy
- NGS
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