New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 6648
Special Issue Editor
Interests: chronic inflammation in inflammatory bowel disease and gastric cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute inflammation is a response to a pathogen or a physical or chemical insult that aims to eliminate the source of the damage and restore homeostasis. In the physiological context, after tissue repair or pathogen elimination, the inflammation is resolved and the homeostatic state recovered. However, unregulated inflammation can become chronic, inducing malignant cell transformation in the surrounding tissue. It is widely accepted that inadequately resolved chronic inflammation is closely linked to cancer development more in the gastrointestinal tract and liver than in any other organs. Examples include Barrett’s esophagitis being a risk factor for esophageal cancer, Helicobacter pylori (H. pylori) infection for gastric cancer and MALT lymphoma, chronic inflammatory bowel diseases for colorectal cancer, and chronic viral hepatitis infection for liver cancer. Inflammation-driven malignancies can result from the complex crosstalk between cytokines, chemokines, growth factors, and reactive oxygen species (ROS) generated by inflammatory cells and injured parenchymal cells.
Despite the clear causal relationship between inflammation and cancers in the gastrointestinal tract, further studies underlying mechanisms and signaling pathways regulated by chronic inflammation activators and inhibitors responsible for this interaction are lacking.
This calls for a focused issue on “New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer” to not only advance knowledge in this field but also evaluate patient outcomes. This Special Issue aims contribute to and communicate advancements in this field.
Themes and questions that we want to address in this Special Issue include, but are not limited to:
- Biomarker discovery;
- Pathogenesis of GI cancer;
- Omics approach to IBD and GI cancer;
- New treatment strategies;
- The natural history of chronic inflammation in IBD;
- The natural history of chronic inflammation towards GI cancer;
- Risk factors of IBD and GI cancer;
- Early diagnosis.
Dr. Laura Francesca Pisani
Guest Editor
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Keywords
- biomarker discovery
- pathogenesis of GI cancer
- omics approach to IBD and GI cancer
- new treatment strategies
- the natural history of chronic inflammation in IBD
- the natural history of chronic inflammation towards GI cancer
- risk factors of IBD and GI cancer
- early diagnosis
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