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Life
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Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition
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Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 3096

Special Issue Editor

Dr. Annunziata Raimondo

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry, University of Salerno, 132, 84084 Fisciano, SA, Italy
Interests: advances in immunopathogenic skin diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The incidence of chronic inflammatory skin diseases, as well as their comorbidities, is constantly growing. Diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic urticaria are characterized by a complex etiopathogenesis involving genetic susceptibility, environmental factors, immunological dysfunction, and alterations of the epidermal barrier. Their severe forms can be enormously disabling and have a negative impact on the quality of life of the affected patients. The clinical course is chronic–remitting–relapsing, with, therefore, the indispensable need to ensure safe and effective therapies. The study of the complex pathogenetic mechanisms will allow the identification of new therapeutic targets, as well as novel biomarkers with diagnostic significance and predictive value for disease severity and response to therapy.

Dr. Annunziata Raimondo
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic inflammatory skin diseases
  • immunopathogenesis
  • inflammatory pathways
  • molecular target
  • biomarkers
  • psoriasis
  • atopic dermatitis
  • hidradenitis suppurativa
  • urticaria
  • skin cancer

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Related Special Issue

Published Papers (2 papers)

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Research

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20 pages, 1941 KiB  
Article
Oral Lesions and Oral Health-Related Quality of Life in Adult Patients with Psoriasis: A Retrospective Chart Review
by Federica Di Spirito, Annunziata Raimondo, Maria Pia Di Palo, Stefano Martina, Mario Fordellone, Donato Rosa, Massimo Amato and Serena Lembo
Life 2024, 14(3), 347; https://doi.org/10.3390/life14030347 - 7 Mar 2024
Cited by 2 | Viewed by 1496
Abstract
Psoriasis is a widespread chronic inflammatory skin disease, that negatively affects physical and emotional well-being and quality of life, as shown by the generally low Dermatology Life Quality Index (DLQI). Psoriasis is burdened by associated comorbidities and some patients manifest concurrent oral lesions, [...] Read more.
Psoriasis is a widespread chronic inflammatory skin disease, that negatively affects physical and emotional well-being and quality of life, as shown by the generally low Dermatology Life Quality Index (DLQI). Psoriasis is burdened by associated comorbidities and some patients manifest concurrent oral lesions, although the existence of oral psoriasis remains controversial. Psoriasis-specific and nonspecific oral lesions and Oral Health-Related Quality of Life (OHRQoL), self-assessed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire, were retrospectively reviewed in adult untreated psoriasis patients with ≥15 teeth, who were non-smokers and had no dental or periodontal infections. Sample (age, gender, comorbidities) and descriptive variables (Body Surface Area-BSA, Psoriasis Area and Severity Index-PASI, Dermatology Life Quality Index-DLQI, severity of psoriasis, distribution of lesions and predominant involvement, years since diagnosis) were correlated with DLQI and OHIP-14 and compared by baseline DLQI and OHRQoL classes. Charts from 90 participants were included. No oral lesions were detected, and excellent/good OHRQoL was found in 94% of the participants. DLQI scores displayed positive significant associations with PASI and BSA, while OHIP-14 with hypertension and IMID, and age. PASI and BSA were significantly higher in participants with DLQI > 10 and also differed significantly among OHQRoL ranks, as well as mucosal involvement and comorbidities. Specifically, among subjects revealing an Excellent OHQRoL, 92.6% were non-IMID, 75% non-hypertensive, 89.7% non-diabetic subjects, 86.8% of non CVD-subjects. Full article
(This article belongs to the Special Issue Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition)
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Review

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Review
The Intersection of the Pathogenic Processes Underlying Psoriasis and the Comorbid Condition of Obesity
by Emanuele Scala, Laura Mercurio, Cristina Albanesi and Stefania Madonna
Life 2024, 14(6), 733; https://doi.org/10.3390/life14060733 - 7 Jun 2024
Viewed by 1224
Abstract
In the past decade, our understanding of psoriasis pathogenesis has made significant steps forward, leading to the development of multiple game-changing therapies. While psoriasis primarily affects the skin, it is increasingly recognized as a systemic disease that can have effects beyond the skin. [...] Read more.
In the past decade, our understanding of psoriasis pathogenesis has made significant steps forward, leading to the development of multiple game-changing therapies. While psoriasis primarily affects the skin, it is increasingly recognized as a systemic disease that can have effects beyond the skin. Obesity is associated with more severe forms of psoriasis and can potentially worsen the systemic inflammation and metabolic dysfunction seen in psoriatic patients. The exact mechanisms underlying the link between these two conditions are not fully understood, but it is believed that chronic inflammation and immune dysregulation play a role. In this review, we examine the existing body of knowledge regarding the intersection of pathogenic processes responsible for psoriasis and obesity. The ability of biological therapies to reduce systemic and obesity-related inflammation in patients with psoriasis will be also discussed. Full article
(This article belongs to the Special Issue Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition)
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