Novel Horizons in the Lung Transplantation Field: Tomorrow Comes Today

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3298

Special Issue Editors


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Guest Editor
Thoracic Surgery Unit, Department of Medicine, Surgery and Neuroscences, Siena University Hospital, 53100 Siena, Italy
Interests: lung transplantation; lung cancer; minimally invasive surgery; robotic surgery; research

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Guest Editor
Thoracic Surgery Unit, Cardio-Thoracic and Vascular Department, Siena University Hospital, 53100 Siena, Italy
Interests: lung transplantation; lung cancer; minimally invasive surgery; robotic surgery; pneumothorax

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to summarize the best evidence regarding the most recent advancements in the lung transplantation field. We are collecting the most significant findings in both research and clinical studies concerning lung transplantation.

We will explore the current use of different ex vivo perfusion techniques, including their limitations and drawbacks, as well as experiences of prolonged preservation. We will discuss the current strategies for the expansion of the donor pool, including marginal donors and donors after cardiac death (DCD) programs, as well as their long-term outcomes. Due to recent successes in the field of xenotransplantation, we will assess in the current state-of-the-art this field and current research on artificial organs. We also would like to discuss the most promising and advanced treatments for chronic and acute rejection, immunosuppression protocols, and biomarkers for the evaluation of long-term outcomes. Another interesting topic to assess would be prophylaxis and treatment of infections related to MDR and atypical pathogens. The final part of the Special Issue will be dedicated to the role of LTX during the COVID-19 pandemic.

Prof. Dr. Piero Paladini
Dr. Marco Ghisalberti
Guest Editors

Manuscript Submission Information

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Keywords

  • lung transplantation
  • CLAD
  • ECMO
  • EVLP
  • xenotransplantation
  • artificial organs
  • MDR germs

Published Papers (2 papers)

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11 pages, 832 KiB  
Article
Bone Disease in Long-Term Lung Transplant Survivors
by Giorgia Grassi, Elisa Cairoli, Lucrezia Maria Silvana Gentile, Iacopo Chiodini, Marta Zampogna, Alberto Ghielmetti, Letizia Corinna Morlacchi, Valeria Rossetti, Lorenzo Rosso, Ilaria Righi, Mario Nosotti, Maura Arosio, Francesco Blasi and Cristina Eller Vainicher
Life 2023, 13(4), 928; https://doi.org/10.3390/life13040928 - 1 Apr 2023
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Abstract
Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our [...] Read more.
Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our study is to compare the skeletal outcomes, after the first 2 years post-LTx, in long-term survivors with CF and nCF. Materials and Methods: We evaluated the FX rate, the changes in bone mineral density (BMD) and trabecular bone score (TBS) in 68 patients (38 CF and 30 nCF) who underwent LTx in our center and with a follow-up after LTx longer than 5 years (7.3 ± 2.0 years). Results: After the second year post-LTx: (i) the FX rate was lower than during the first two years post-LTx (4.4 vs. 20.6%, p = 0.004), with no difference between CF and nCF patients (5.3 vs. 3.3%, p = 0.589); (ii) BMD at lumbar spine, femoral neck and total hip remained stable (−1.6 ± 1.0 vs. −1.4 ± 1.1, p = 0.431, −1.8 ± 0.9 vs. −1.9 ± 0.9, p = 0.683, −1.5 ± 0.9 vs. −1.4 ± 0.9, p = 0.678, respectively) as well as TBS (1.200 ± 0.124 vs. 1.199 ± 0.205, p = 0.166). Conclusions: After the second year post-LTx, the skeletal complications become less frequent and have similar incidence in patients with CF and nCF. Full article
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10 pages, 1779 KiB  
Opinion
Thoracic Ultrasound in Lung Transplantation—Insights in the Field
by Hans Henrik Lawaetz Schultz and Jesper Rømhild Davidsen
Life 2023, 13(3), 695; https://doi.org/10.3390/life13030695 - 4 Mar 2023
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Abstract
The use of thoracic ultrasound (TUS) is a novel and dynamic diagnostic and monitoring modality that has shown remarkable advances within the last decade, with several published papers investigating its role within the field of lung transplantation. The aim of this current opinion [...] Read more.
The use of thoracic ultrasound (TUS) is a novel and dynamic diagnostic and monitoring modality that has shown remarkable advances within the last decade, with several published papers investigating its role within the field of lung transplantation. The aim of this current opinion review is to review the existing literature on the role of TUS in all stages of LTx, from in-donor lung evaluation to graft assessment on ex vivo lung perfusion and in the short- and long-term follow-up after LTx. Full article
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