Prognosis and Management of Dry Eye Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 239

Special Issue Editors


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Guest Editor
GI-2092—Optometry, Department of Applied Physics (Optometry Area), Universidade de Santiago de Compostela, Campus Vida s/n, Santiago de Compostela, Spain
Interests: dry eye disease; ocular surface; contact lens; tear substitutes

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Guest Editor
Department of Ophthalmology, Faculty of Medicine, Comenius University, 826 01 Bratislava, Slovakia
Interests: ophthalmology; melanoma; uveal melanoma
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
GI-2092—Optometry, Department of Applied Physics (Optometry Area), Universidade de Santiago de Compostela, Campus Vida s/n, Santiago de Compostela, Spain
Interests: dry eye disease; ocular surface; contact lens; tear substitutes

Special Issue Information

Dear Colleagues,

Dry eye is a complex condition of the ocular surface characterized by a disturbance in the homeostasis of the tear film, leading to ocular signs and symptoms. This condition may have a significant impact on the quality of life of those who suffer from it, as well as on the global economy due to the costs of treatment and loss of productivity.

Some studies have suggested that dry eye could impact up to 50% of the global population, whereas others estimate its association with only 5–10% of pollution. These discrepancies often stem from differences in diagnostic criteria or even in the definition of the disorder itself. While previous reports have explored certain tests as single-gold standard markers for dry eye detection, disparities in results have been revealed. This underscores the need for validation studies based on specific designs. Investigating new assessment methodologies may offer a more efficient and optimized approach, providing valuable insights that could enhance diagnostic precision and expedite the identification of these ocular disorders.

Moreover, due to the lack of a clear definition or diagnosis, there is a gap in well-designed studies that monitor changes in dry eye signs, symptoms, status, and severity over time, as well as in the natural history of treated or untreated patients. This also leads to problems and discrepancies in patient management that will increase the human and economic cost of the disease.

In response to the demands of the scientific research community, the implementation of well-designed studies is imperative. This Special Issue aims to compile knowledge regarding the definition, epidemiology, diagnosis, natural course, and management of dry eye disorders.

Dr. Hugo Pena-Verdeal
Dr. Alena Furdova
Dr. Jacobo Garcia-Queiruga
Guest Editors

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Keywords

  • dry eye disease
  • dry eye epidemiology
  • dry eye management
  • dry eye natural course
  • meibomian gland dysfunction
  • evaporative dry eye
  • aqueous deficiency dry eye
  • artificial tear substitutes
  • tear film lipid layer
  • meibomian glands

Published Papers (1 paper)

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Research

11 pages, 713 KiB  
Article
Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers
by Jacobo Garcia-Queiruga, Hugo Pena-Verdeal, Belen Sabucedo-Villamarin, Carlos Garcia-Resua, Maria J. Giraldez and Eva Yebra-Pimentel
Life 2024, 14(7), 806; https://doi.org/10.3390/life14070806 (registering DOI) - 26 Jun 2024
Viewed by 97
Abstract
Background: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study [...] Read more.
Background: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. Methods: This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Results: Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005). Conclusion: Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups. Full article
(This article belongs to the Special Issue Prognosis and Management of Dry Eye Disease)
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