Dermatology and Oxidative Stress

Dear Colleagues,

Oxidative stress has recently been recognized as playing a pivotal role in the pathogenesis of various disorders such as cardiovascular diseases, neurodegenerative disorders, viral infections, and skin diseases. In the human body, reactive oxygen species (ROS) have a dual role, as they participate in the defense against pathogens and in maintaining cell homeostasis, but at the same time, when they accumulate in high concentrations, they may exert harmful effects on the host cells, leading to various tissue injuries. 

On the skin, ROS induce the appearance of erythema, edema, or pain and play a major role in the aging process. There is an intense debate around whether oxidative stress initiates pathogenic processes that result in skin diseases or is a consequence of the activity of inflammatory cells involved in disease pathogenesis. Numerous studies attest to the link between inflammation and oxidative stress. The relationship between inflammation and oxidative stress is bidirectional because inflammatory cells release ROS, but ROS in turn can activate pathways involved in chronic inflammation. In this context, studies increasingly suggest that oxidative stress plays a crucial role in the pathogenesis of numerous inflammatory/autoimmune skin diseases such as alopecia areata, vitiligo, lichen planus, psoriasis, etc. It should also be noted that ROS have a genotoxic effect, and prolonged exposure to ROS in the context of chronic inflammation can lead to malignancy. 

Investigating the effects of the imbalance between prooxidants and antioxidants on cell signaling pathways, cell differentiation, and apoptosis could yield valuable insights into the mechanisms underlying many diseases.

The aim of this Special Issue is to explore recent advances in research involving the role of oxidative stress in the pathogenesis of skin diseases, new markers of oxidative stress for the diagnosis and monitoring of skin diseases, antioxidant therapies, and the link between oxidative stress and skin carcinogenesis. We welcome researchers to submit original research manuscripts and reviews to provide readers with a better understanding of the relationship between oxidative stress and skin diseases.

Dr. Cristina Iulia Mitran
Dr. Madalina Irina Mitran
Dr. Mircea Tampa
Prof. Dr. Simona Roxana Georgescu
Guest Editors

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• markers of oxidative stress
• ROS-mediated cellular signaling
• chronic inflammation
• skin carcinogenesis
• skin aging
• skin infections
• autoimmunity
• antioxidant therapies