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Life
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Veterinary Pathology and Veterinary Anatomy: 3rd Edition
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Veterinary Pathology and Veterinary Anatomy: 3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Animal Science".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1186

Special Issue Editors

Prof. Dr. Gheorghe Solcan

E-Mail Website
Guest Editor
Internal Medicine Unit, Clinics Department, Faculty of Veterinary Medicine, Iași University of Life Sciences Ion Ionescu de la Brad, Iasi, Romania
Interests: veterinary medicine; internal medicine; toxicology; dermatology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carmen Solcan

E-Mail Website
Guest Editor
Histology and Molecular Biology, Department of Preclinics, Ion Ionescu de la Brad University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, Romania
Interests: veterinary medicine; veterinary pathology; veterinary anatomy; animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Life titled “Veterinary Pathology and Veterinary Anatomy: 3rd Edition” is dedicated to the study of veterinary disease and physiology and encompasses various aspects of pathology in domestic and wild animals, such as the following:

  • New challenges for veterinary pathology in the context of the SARS-CoV-2 pandemic; animals as potential reservoirs for SARS-CoV-2 and for other potential pandemics;
  • New challenges for veterinary pathology induced by climate change and the spread of tropical diseases in the northern hemisphere;
  • Challenges for pathology induced by armed conflicts;
  • Diseases transmissible from animals to humans and from wild to domestic animals and means of prevention. Animal pandemics have major economic and social impacts: African swine fever, avian influenza, ruminant pest, etc.;
  • Diseases caused by industrial toxins, environmental pollution, and mycotoxins (current state of pathogenetic mechanisms, diagnosis, and means of prevention);
  • Epidemiology of non-communicable diseases concerning environmental pollution (allergies, cancer, and degenerative diseases).

This Special Issue also focuses on new developments in diagnosing and treating animal diseases. Original manuscripts covering various aspects of veterinary pathology are requested. Papers reporting new solutions to common problems and new descriptions of lesser-recognized conditions are particularly welcome. In addition, we encourage papers detailing advanced diagnostic techniques, the use of microscopic anatomy in diagnosis, and computer modeling of pathological processes.

Given that the first and second editions of this Special Issue were great successes, we now invite you to publish in the third edition (https://www.mdpi.com/journal/life/special_issues/S5REQE7J13, https://www.mdpi.com/journal/life/special_issues/5YJ9L17412).

Prof. Dr. Gheorghe Solcan
Prof. Dr. Carmen Solcan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary pathology
  • veterinary anatomy
  • SARS-CoV-2 pandemic
  • climate change
  • environmental pollution
  • diagnosis and treatment of animal diseases
  • computer modelling of pathological processes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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35 pages, 3356 KiB  
Article
Combined Neurotoxic Effects of Commercial Formulations of Pyrethroid (Deltamethrin) and Neonicotinoid (Imidacloprid) Pesticides on Adult Zebrafish (Danio rerio): Behavioral, Molecular, and Histopathological Analysis
by Adriana Petrovici, Gheorghe Savuța, Carla Lucini, Madalina-Andreea Robea and Carmen Solcan
Life 2025, 15(4), 538; https://doi.org/10.3390/life15040538 - 25 Mar 2025
Viewed by 703
Abstract
The use of different commercial products that involve one or multiple active substances with specific targeted-pests control has become a widespread practice. Because of this, a severe range of significant consequences has been often reported. Among the most used pesticides worldwide are deltamethrin [...] Read more.
The use of different commercial products that involve one or multiple active substances with specific targeted-pests control has become a widespread practice. Because of this, a severe range of significant consequences has been often reported. Among the most used pesticides worldwide are deltamethrin (DM) and imidacloprid (IMI). With a significative effect on the insect’s nervous system, DM acts on the voltage-gated sodium channels in nerve cell membranes, while IMI mimics the acetylcholine neurotransmitter by binding irreversibly to the nicotinic acetylcholine receptors. This study investigates the neurotoxic effects of sub-chronic exposure to commercial formulations of deltamethrin (DM) and imidacloprid (IMI) in adult zebrafish, both individually and in combination. The formulations used in this study contain additional ingredients commonly found in commercial pesticide products, which may contribute to overall toxicity. Fish were exposed to environmentally relevant concentrations of these pesticides for 21 days, individually or in combination. Behavioral, molecular, and histopathological analyses were conducted to assess the impact of these pesticides. Zebrafish exhibited dose-dependent behavioral alterations, particularly in the combined exposure groups, including increased erratic swimming and anxiety-like behavior. Gene expression analysis revealed significant changes in neurotrophic factors (BDNF, NGF, ntf-3, ntf-4/5, ntf-6/7) and their receptors (ntrk1, ntrk2a, ntrk2b, ntrk3a, ntrk3b, ngfra, ngfrb), indicating potential neurotoxic effects. Histopathological examination confirmed neuronal degeneration, gliosis, and vacuolization, with more severe impairments observed in pesticide mixture treatments. These findings highlight the neurotoxic potential of pesticide formulations in aquatic environments and emphasize the need for stricter regulations on pesticide mixtures and further research on pesticide interactions. Our findings emphasize that the combination of pesticides could trigger a synergistic effect by maximizing the toxicity of each compound. Thus, it is a well-known practice for pyrethroids and neonicotinoids to be used together in agriculture. Even so, its prevalence in agriculture and the need to investigate its actual impact on human health, biodiversity, and ecosystem mitigates the development of new strategies for assessing the risk and, at the same time, enhancing the effectiveness. Full article
(This article belongs to the Special Issue Veterinary Pathology and Veterinary Anatomy: 3rd Edition)
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Review

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15 pages, 1280 KiB  
Review
New World Primates and Their Human Counterparts Share Diseases That Abound with CEACAM and Other Effector Molecules
by Martin Tobi, Daniel Ezekwudo, Benita McVicker, Harvinder Talwar, Laura Kresty, Elizabeth Curran, Ronald Veazey, Peter J. Didier, James Hatfield, Mike Lawson and Sonia M. Najjar
Life 2025, 15(3), 481; https://doi.org/10.3390/life15030481 - 17 Mar 2025
Viewed by 294
Abstract
Background: Herein, we review the Cotton Top Tamarin (CTT), Saguinus oedipus, a unique spontaneous model for colorectal cancer (CRC). Despite its predisposition to inflammatory bowel disease (IBD) and frequent development of CRC, the CTT is adept at avoiding colorectal metastasis in the [...] Read more.
Background: Herein, we review the Cotton Top Tamarin (CTT), Saguinus oedipus, a unique spontaneous model for colorectal cancer (CRC). Despite its predisposition to inflammatory bowel disease (IBD) and frequent development of CRC, the CTT is adept at avoiding colorectal metastasis in the liver. In contrast, the common marmoset (CM), Callithrix jacchus, is a natural negative control, in that it also contracts IBD, but usually not CRC. We review our findings in these New World monkeys in terms of the expression of CEACAM adhesion models and their related molecules to contrast them with human disease. Methods: Specimens were collected from aforementioned monkey colorectal and other tissues, colonic washings, serum for analysis of tissue extraction, and colonic washings via ELISA, using a battery of antibodies. Fixed tissues were analyzed using immunohistochemistry and CEACAMs were extracted via Western blotting. Serum CEA levels were analyzed using ELISA, and DNA was extracted via a Bigblast genomics sequencing kit. Results: Serum CEA was significantly elevated in CTTs, and one-third of them die from CRC. Unlike others, we were unable to stain for CEA in tissues. The sialylated carbohydrate antigen recognized by monoclonal antibody (MAb) SPAN-1 does stain in 16.7% of CTT tissues, but the anti-aminoproteoglycan MAb, CaCo.3/61, stained 93.3% (OR70·00[CI6.5–754.5] p < 0.0001). The common CEA kits from Abbott and Roche were non-conclusive for CEA. We later adopted a CEA AIA-PACK from Tosoh Medics, which identified a 50 Kda band via Western blotting in humans and CTTs. The CEA levels were higher using the CEA AIA-PACK than the Pharmatrope kit (932 ± 690 versus 432 ± 407 ng/mL (p < 0.05)) in human patient colonic effluent, not statistically significant (NSS) for CTT extracts or effluent (733 ± 325 and 739 ± 401 ng/mL, respectively). It was suggested that the smaller CTT CEA moiety might lack components that facilitate the spread of liver metastasis. Later, using more specific CEA assays and increased numbers of specimens, we were able to show higher CEA serum expression in CTTs than in CMs (632.1 ± 306.1 vs. 81.6 ± 183.6, p < 0.005), with similar differences in the serum samples. Western blotting with the anti-CEA T84.66 MAb showed bands above 100 KDa in CTTs. The profiles in CTTs were similar to human patients with inflammatory bowel disease. We established that the CEA anchorage to the cell was a GPI-linkage, advantageous for the inhibition of differentiation and anoikis. With further CEA DNA analysis, we were able to determine at least five different mechanisms that may inhibit liver metastasis, mostly related to CEA, but later expanded this to seven, and increased the relationships to CEACAM1 and other related molecules. Recently, we obtained CTT liver mRNA transcriptomes that implicated several pathways of interest. Conclusions: With efforts spanning over three decades, we were able to characterize CEA and other changes that allow us to better understand the CTT phenomenon of liver metastasis inhibition. We are in the process of characterizing the CTT liver mRNA transcriptome to compare it with that of the common marmoset. Currently, liver CTT gene expression patterns suggest that ribosomes, lipoproteins, and antioxidant defense are related to differences between CTTs and CMs. Full article
(This article belongs to the Special Issue Veterinary Pathology and Veterinary Anatomy: 3rd Edition)
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