Advances in Arterial Stiffness Research

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (16 September 2022) | Viewed by 4708

Special Issue Editors


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Guest Editor
2nd Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
Interests: arterial stiffness; preclinical vascular disease; atherosclerosis; chronic systemic inflammation; vascular ultrasonography; echocardiography

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Guest Editor
Department of Medical Sciences II—Pharmacology, Clinical Pharmacology and Algesiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 lași, Romania
Interests: arterial stiffness; adherence; antibiotics; stress hormones; clinical pharmacology; experimental pharmacology
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Guest Editor
Clinical Rehabilitation Hospital–Cardiovascular Rehabilitation Clinic, ”Grigore T. Popa” University of Medicine and Pharmacy, 700115 lași, Romania
Interests: cardiology; ischemic cardiac disease; stress test; arterial hypertension; arterial stiffness; cardiac rehabilitation; cardiac biomarkers; cardiac failure
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Arterial stiffness has been intensively studied in the last several decades as a non-invasive marker of preclinical vascular disease. Increased aortic stiffness has been shown to predict cardiovascular risk independently of traditional risk factors and to improve risk reclassification, especially for intermediate-risk patients. The stiffness of central arteries has important cardiac consequences, leading to increased left ventricular afterload and subsequent myocardial disfunction. Moreover, stiff arteries induce an increase in distal pulsatility, causing tissue damage in highly vascularized organs such as brain and kidney. Age is the main determinant of arterial stiffness, but hypertension, diabetes or chronic kidney diseases may cause rapid arterial aging and increase the risk of future cardiovascular events. Non-invasive methods to measure arterial stiffness are available, and may allow an early diagnosis of vascular damage.

Even though great progress has been made in arterial stiffness research, many questions in this field remain open. Thus, this Special Issue will focus particularly on the study of still-unclarified aspects regarding arterial stiffness, such as pathogenic mechanisms, clinical evaluation and implications, as well as therapeutic strategies.

We cordially invite researchers and practitioners to submit original manuscripts reporting basic and clinical research as well as reviews that address these broad topics.

Dr. Adriana Albu
Dr. Cristina Mihaela Ghiciuc
Dr. Florin Mitu
Guest Editors

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Keywords

  • arterial stiffness
  • preclinical vascular disease
  • pulse wave velocity
  • cardiovascular risk
  • vascular aging

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Published Papers (2 papers)

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Research

13 pages, 2390 KiB  
Article
Negative Impact of the UEFA European Soccer Championship on Central Hemodynamics and Arterial Stiffness: A Multicenter Study
by Klaas F. Franzen, Kai Mortensen, Christian Ott, Katrin Herber, Marlene Busse, Charlotte Söling, Daniel Schneppe, Saskia Lässig, Marcus Dörr, Roland Tilz, Daniel Drömann, Heribert Schunkert and Michael Reppel
Life 2022, 12(11), 1696; https://doi.org/10.3390/life12111696 - 25 Oct 2022
Cited by 2 | Viewed by 1486
Abstract
(1) Background: watching sporting events may trigger cardiovascular events by elevating emotional stress levels. The underlying reasons and specific populations at risk are not well defined. (2) Methods: we conducted a multicenter prospective trial at three German sites during the UEFA Soccer EC [...] Read more.
(1) Background: watching sporting events may trigger cardiovascular events by elevating emotional stress levels. The underlying reasons and specific populations at risk are not well defined. (2) Methods: we conducted a multicenter prospective trial at three German sites during the UEFA Soccer EC 2012 and 2021 comprising 52 healthy participants (noCVD) and 18 patients hospitalized with cardiovascular disease (CVD). Subjects were studied during matches of the German national team (GP) as well as corresponding matches without German participation (noGP). Peripheral and central blood pressure (BP) and parameters of arterial stiffness were measured (Mobil-O-Graph™, I.E.M., Stolberg, Germany) before, during, and after the matches. (3) Results: in terms of CVD, peripheral as well as central BP and heart rate increased significantly during GP as well as noGP matches and remained elevated beyond the end of the matches. Likewise, arterial stiffness parameters and vascular resistance were higher during the matches and remained elevated after the matches. No consistent significant differences were found between GP and noGP matches. (4) Conclusions: this is the first study on real-life changes in hemodynamics during sport-associated emotional stress, with comparison between noCVD and CVD. We found that alterations were profound in CVD and remained elevated even after the matches. Full article
(This article belongs to the Special Issue Advances in Arterial Stiffness Research)
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8 pages, 946 KiB  
Article
Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis
by Kai-Hsiang Chang, Chih-Hsien Wang, Bang-Gee Hsu and Jen-Pi Tsai
Life 2022, 12(3), 397; https://doi.org/10.3390/life12030397 - 9 Mar 2022
Cited by 4 | Viewed by 1963
Abstract
Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by [...] Read more.
Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Patients with cfPWV > 10 m/s were designated into the AS group. Results: Twenty-two patients (31.4%) were segregated into the AS group. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS. The receiver operating characteristic curve analysis showed that OPN was correlated with AS with an area under the curve of 0.903 (95% CI 0.809–0.961, p < 0.001). Conclusions: For PD patients, the serum OPN level was correlated with cfPWV and could play an important role in the process of AS. Full article
(This article belongs to the Special Issue Advances in Arterial Stiffness Research)
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