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Materials for Drug Delivery and Medical Engineering
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Materials for Drug Delivery and Medical Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 629

Special Issue Editors

Dr. Keisuke Nakano

E-Mail Website
Guest Editor
Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan
Interests: tissue engineering; biomaterials; tumorigenesis; bone formation; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Kiyofumi Takabatake

E-Mail Website
Guest Editor
Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan
Interests: histopathology; biomaterials; tumor microenvironment; regenerative medicine; material science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of medical engineering has witnessed significant advancements, primarily driven by the need for effective drug delivery systems. These systems are essential in ensuring that therapeutic agents reach their intended targets in the body, maximizing efficacy while minimizing side effects. The materials employed in drug delivery and medical engineering must possess specific characteristics to fulfill these roles, including biocompatibility, biodegradability, and controlled release profiles.

The selection of materials is paramount, as they must facilitate the appropriate release of drugs at the desired rate and location within the body. Common materials include polymers, metallic materials, ceramics, and nanomaterials, which have gained prominence due to their unique properties, such as facilitating enhanced drug delivery, implanting, supporting biological functions, and so on.

The interplay between materials science and medical engineering is crucial for the development of innovative drug delivery systems. As research continues to evolve, the focus remains on creating advanced materials that enhance therapeutic outcomes, ultimately leading to improved patient care.

Dr. Keisuke Nakano
Dr. Kiyofumi Takabatake
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multifunctional materials
  • polymers
  • ceramics
  • metallic materials
  • nanomaterials
  • drug delivery
  • drug release
  • tissue engineering
  • biocompatibility
  • medical
  • implants

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Published Papers (2 papers)

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Research

28 pages, 15656 KiB  
Article
Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation
by Sebastião Júlio Rodrigues Júnior, Letícia Carlucci dos Santos, Daniela Vieira Buchaim, Marco Antonio Hungaro Duarte, Murilo Priori Alcalde, Benedito Barraviera, Rui Seabra Ferreira Júnior, Ana Maria de Guzzi Plepis, Virgínia da Conceição Amaro Martins, Paulo Sérgio da Silva Santos, Marcelo Rodrigues da Cunha, Rogerio Leone Buchaim and Karina Torres Pomini
Materials 2025, 18(8), 1704; https://doi.org/10.3390/ma18081704 - 9 Apr 2025
Viewed by 112
Abstract
Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and have limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting with scaffolds for bone growth and use of photobiomodulation (PBM) to [...] Read more.
Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and have limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting with scaffolds for bone growth and use of photobiomodulation (PBM) to accelerate this tissue repair. Thus, the objective was to evaluate the effect of PBM in the repair of a long bone (tibia) of rats filled with biomimetic collagen matrices with nanohydroxyapatite and heterologous fibrin biopolymer (FB). Forty-eight rats were distributed into eight groups (n = six each): Blood Clot (BC), Blood Clot + PBM (BCP), Matrix (M), Matrix + PBM (MP), Fibrin Biopolymer (FB), Fibrin Biopolymer + PBM (FBP), Matrix + FB (MFB), Matrix + FB + PBM (MFBP). A 2.0 mm bone defect was created in the proximal third of the left tibia. The BCP, MP, FBP, and MFBP groups underwent PBM during surgery and maintained twice a week until euthanasia at 42 days. Microcomputed tomography (micro-CT), histomorphological and histomorphometric analyses were performed. Micro-CT analysis revealed that PBM influenced cortical interposition between the remnant and newly formed bone. Histologically, no exacerbated inflammatory focus or foreign body-type granulomatous reaction was observed in any group; however, a vast collagenous matrix with a more oriented and thicker spatial conformation was observed in the PBM-treated groups. Histomorphometrically, the BCP, MP, and MFBP groups showed significantly higher values compared to the other groups. Specifically, the BC group presented a mean bone tissue density of 68.33 ± 7.394, while the BCP and MP groups showed 99.83 ± 11.87 and 99.67 ± 20.58, respectively (p < 0.05). Qualitative analysis of collagen fibers indicated enhanced organization and maturation in PBM-treated groups. This study concluded that the association of PBM in the repair of long bones in rats, filled with biomimetic collagen matrices with nanohydroxyapatite and fibrin biopolymer, presented results that contribute to the improvement of bone growth, together with the association of scaffolds. Full article
(This article belongs to the Special Issue Materials for Drug Delivery and Medical Engineering)
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33 pages, 12074 KiB  
Article
PVP as an Oxygen Vacancy-Inducing Agent in the Development of Black 45S5 Bioactive Glass Fibrous Scaffolds Doped with Zn and Mg Using A-HSBS
by Keila C. Costa, Maria Geórgia da S. Andrade, Rondinele N. de Araujo, Adegildo R. de Abreu Junior, Marianna V. Sobral, Juan Carlos R. Gonçalves, Bianca V. Sousa, Gelmires A. Neves and Romualdo R. Menezes
Materials 2025, 18(6), 1340; https://doi.org/10.3390/ma18061340 - 18 Mar 2025
Viewed by 364
Abstract
Currently, there is an increasing demand for advanced materials that can address the needs of tissue engineering and have the potential for use in treatments targeting tumor cells, such as black bioactive materials in photothermal therapy. Thus, 3D fibrous scaffolds of black 45S5 [...] Read more.
Currently, there is an increasing demand for advanced materials that can address the needs of tissue engineering and have the potential for use in treatments targeting tumor cells, such as black bioactive materials in photothermal therapy. Thus, 3D fibrous scaffolds of black 45S5 bioactive glass were produced using the air-heated solution blow spinning (A-HSBS) technique, with polyvinylpyrrolidone (PVP) serving as a spinning aid and an oxygen vacancy-inducing agent. Glass powder with the same composition was synthesized via the sol-gel route for comparison. The samples were characterized using thermogravimetric analysis, X-ray diffraction, FTIR spectroscopy, and scanning electron microscopy, along with in vitro tests using simulated body fluid (SBF), phosphate-buffered saline (PBS), and TRIS solution. The results showed that PVP enhanced oxygen vacancy formation and stabilized the scaffolds at 600 °C. Doping with Zn and Mg ions reduced crystallization while significantly increasing the fiber diameters. Scaffolds doped with Zn exhibited lower degradation rates, delayed apatite formation, and hindered ionic release. Conversely, Mg ions facilitated greater interaction with the medium and rapid apatite formation, completely covering the fibers. The scaffolds showed no cytotoxicity in the MTT assay at concentrations of up to 200 µg/mL for HaCat cells and 0.8 mg/mL for L929 cells. This study demonstrated the effectiveness of using PVP in the production of black bioactive glass scaffolds, highlighting their potential for bone regeneration. Full article
(This article belongs to the Special Issue Materials for Drug Delivery and Medical Engineering)
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