Development and Applications of Multi-Scale Mathematical Models in Cardiology

Dear Colleagues,

Over the last years different types of mathematical models have proven to be able to capture the complex dynamic behavior of the heart at different scales, from the cell to the organ level. There are different approaches depending on the final goal, from detailed biophysical models that can account on subcellular details, allowing for instance to model the effect of drugs, to phenomenological models that can reproduce the macroscopic behavior of the heart and help in decision-making tasks. Both types of models usually take into account the cellular, tissue and organ levels separately and with different levels of detail.

The purpose of this special issue is to establish the current state-of-the art in mathematical modeling of the heart that can lead to the digital twin concept, taking into account the final purpose of each type of model, as well as their advantages and applications in medicine.  Of special interest are research papers that deal with multi-scale biophysical models, mathematical models that are validated for translation into real clinical environments, and simplified phenomenological models that are accurate and can deliver results in times compatible with clinical environments.

Dr. Rafael Sebastian
Guest Editor

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