Machine-Learning-Based Process and Analysis of Medical Images

A special issue of Mathematics (ISSN 2227-7390). This special issue belongs to the section "Mathematics and Computer Science".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 4994

Special Issue Editor

Department of Radiology, Northwestern University, Chicago, IL, USA
Interests: medical image analysis; deep learning; computer vision; machine learning; colonoscopy; gastrointestinal endoscopy; wireless capsule endoscopy; surgical data science; radiation oncology; radiation therapy; organs at risk; prostate, liver, and lung cancer; robustness, generalization, and trustworthy AI systems; transparent system; out-of-distribution detection; reproducibility

Special Issue Information

Dear Colleagues,

In recent years, deep learning has achieved impressive success in leading to increased use of deep learning algorithms in the different fields of medical image analysis tasks. However, there are several challenges with the current deep learning models, such as deep learning algorithms being data-hungry and requiring large amounts of labeled data for achieving high performance in supervised learning settings. The collection of a large dataset requires a lot of time, resources including qualified medical experts, infrastructure, interdisciplinary collaboration, and regulatory approvals. In addition to obtaining datasets, a team of experienced doctors and computer scientists are required to provide high-quality annotations, which is extremely labor-intensive and burdensome. Despite data collection and annotations, it is not feasible to deploy large deep learning models to edge devices for various medical applications within a resource-constrained situation. The current deep learning models are not robust, and their performance can drop when there is a change in conditions (such as testing with different cohort populations, and scanners), which leads to challenges in deploying deep learning models into real-world clinical applications.  The trustworthiness and societal impact of such models have not been explored much. Despite the minimal amount of research carried out to address the limitations of the availability of limited datasets, label efficiency, and lightweight algorithms, these fields have not been fully explored. Therefore, in this Special Issue, we encourage submissions on potential research problems raised by limited datasets, label efficiency, hardware efficiency, and trustworthy and reproducible (training time and testing) deep learning that can prepare for more biomedical applications in future. This Special Issue will be devoted to unveiling the most recent progress in obtaining analytical and numerical solutions to nonlinear differential equations through various methods and to stimulating collaborative research activities.

Dr. Debesh Jha
Guest Editor

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Keywords

  • deep learning (architecture, generative models, real-time algorithms, lightweight network design, etc.)
  • medical image segmentation/classification with limited training datasets
  • trustworthy machine learning (privacy, fairness, transparency, safety, ethics, AI safety, etc.)
  • computer-aided diagnosis
  • image segmentation
  • weakly/semi/unsupervised/self-supervised learning methods
  • resource-efficient learning
  • out-of-distribution detection
  • early cancer detection and diagnosis
  • single-shot/one-shot/few-shot learning methods
  • imaging informatics
  • domain adaptation
  • biomedical applications (endoscopy, colonoscopy, Alzheimer's disease, laparoscopy, head and neck, organs at risk, prostate, lung cancer, liver, breast, etc.)
  • rare disease diagnosis with limited training datasets
  • surgical data science

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Published Papers (3 papers)

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Research

19 pages, 6172 KiB  
Article
MS-UNet: Multi-Scale Nested UNet for Medical Image Segmentation with Few Training Data Based on an ELoss and Adaptive Denoising Method
by Haoyuan Chen, Yufei Han, Linwei Yao, Xin Wu, Kuan Li and Jianping Yin
Mathematics 2024, 12(19), 2996; https://doi.org/10.3390/math12192996 - 26 Sep 2024
Viewed by 1017
Abstract
Traditional U-shape segmentation models can achieve excellent performance with an elegant structure. However, the single-layer decoder structure of U-Net or SwinUnet is too “thin” to exploit enough information, resulting in large semantic differences between the encoder and decoder parts. Things get worse in [...] Read more.
Traditional U-shape segmentation models can achieve excellent performance with an elegant structure. However, the single-layer decoder structure of U-Net or SwinUnet is too “thin” to exploit enough information, resulting in large semantic differences between the encoder and decoder parts. Things get worse in the field of medical image processing, where annotated data are more difficult to obtain than other tasks. Based on this observation, we propose a U-like model named MS-UNet with a plug-and-play adaptive denoising module and ELoss for the medical image segmentation task in this study. Instead of the single-layer U-Net decoder structure used in Swin-UNet and TransUNet, we specifically designed a multi-scale nested decoder based on the Swin Transformer for U-Net. The proposed multi-scale nested decoder structure allows for the feature mapping between the decoder and encoder to be semantically closer, thus enabling the network to learn more detailed features. In addition, ELoss could improve the attention of the model to the segmentation edges, and the plug-and-play adaptive denoising module could prevent the model from learning the wrong features without losing detailed information. The experimental results show that MS-UNet could effectively improve network performance with more efficient feature learning capability and exhibit more advanced performance, especially in the extreme case with a small amount of training data. Furthermore, the proposed ELoss and denoising module not only significantly enhance the segmentation performance of MS-UNet but can also be applied individually to other models. Full article
(This article belongs to the Special Issue Machine-Learning-Based Process and Analysis of Medical Images)
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21 pages, 4350 KiB  
Article
Generalized Framework for Liquid Neural Network upon Sequential and Non-Sequential Tasks
by Prakash Kumar Karn, Iman Ardekani and Waleed H. Abdulla
Mathematics 2024, 12(16), 2525; https://doi.org/10.3390/math12162525 - 15 Aug 2024
Cited by 1 | Viewed by 1507
Abstract
This paper introduces a novel approach to neural networks: a Generalized Liquid Neural Network (GLNN) framework. This design excels at handling both sequential and non-sequential tasks. By leveraging the Runge Kutta DOPRI method, the GLNN enables dynamic simulation of complex systems across diverse [...] Read more.
This paper introduces a novel approach to neural networks: a Generalized Liquid Neural Network (GLNN) framework. This design excels at handling both sequential and non-sequential tasks. By leveraging the Runge Kutta DOPRI method, the GLNN enables dynamic simulation of complex systems across diverse fields. Our research demonstrates the framework’s capabilities through three key applications. In predicting damped sinusoidal trajectories, the Generalized LNN outperforms the neural ODE by approximately 46.03% and the conventional LNN by 57.88%. Modelling non-linear RLC circuits shows a 20% improvement in precision. Finally, in medical diagnosis through Optical Coherence Tomography (OCT) image analysis, our approach achieves an F1 score of 0.98, surpassing the classical LNN by 10%. These advancements signify a significant shift, opening new possibilities for neural networks in complex system modelling and healthcare diagnostics. This research advances the field by introducing a versatile and reliable neural network architecture. Full article
(This article belongs to the Special Issue Machine-Learning-Based Process and Analysis of Medical Images)
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17 pages, 5158 KiB  
Article
nmPLS-Net: Segmenting Pulmonary Lobes Using nmODE
by Peizhi Dong, Hao Niu, Zhang Yi and Xiuyuan Xu
Mathematics 2023, 11(22), 4675; https://doi.org/10.3390/math11224675 - 17 Nov 2023
Cited by 3 | Viewed by 1048
Abstract
Pulmonary lobe segmentation is vital for clinical diagnosis and treatment. Deep neural network-based pulmonary lobe segmentation methods have seen rapid development. However, there are challenges that remain, e.g., pulmonary fissures are always not clear or incomplete, especially in the complex situation of the [...] Read more.
Pulmonary lobe segmentation is vital for clinical diagnosis and treatment. Deep neural network-based pulmonary lobe segmentation methods have seen rapid development. However, there are challenges that remain, e.g., pulmonary fissures are always not clear or incomplete, especially in the complex situation of the trilobed right pulmonary, which leads to relatively poor results. To address this issue, this study proposes a novel method, called nmPLS-Net, to segment pulmonary lobes effectively using nmODE. Benefiting from its nonlinear and memory capacity, we construct an encoding network based on nmODE to extract features of the entire lung and dependencies between features. Then, we build a decoding network based on edge segmentation, which segments pulmonary lobes and focuses on effectively detecting pulmonary fissures. The experimental results on two datasets demonstrate that the proposed method achieves accurate pulmonary lobe segmentation. Full article
(This article belongs to the Special Issue Machine-Learning-Based Process and Analysis of Medical Images)
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