Cardiac Transplantation: Clinical Outcome, Complications and Follow-Up

Dear Colleagues,

Cardiac transplantation represents the gold-standard treatment for patients with end-stage heart failure as it is associated with improved survival and quality of life in these patients. However, its wider application is limited by the scarce availability of suitable organ donors. The huge discrepancy between the growing number of patients suffering from heart failure and the limited number of donors has led to an increase in the use of left ventricular assist devices as a bridge to transplant therapy. New strategies are required to supplement the donor pool, including the expansion of criteria for acceptance of organ donor, the use of non-heart-beating donors, and the development of optimal preservation and perfusion techniques for the reconditioning of the heart after cardiac arrest. Cardiac transplantation may be complicated by primary graft dysfunction, acute allograft rejection, cardiac allograft vasculopathy, infection, acute and chronic renal failure, solid tumors, and hematological malignancy. This Special Issue in Medicina aims to address the whole spectrum of cardiac transplantation including clinical outcome, diagnostic and treatment of the main complications, and follow-up. Comprehensive reviews, original research (be it basic, translational, or clinical research), interesting case series or case reports, and systematic reviews or meta-analyses providing new insights into cardiac transplantation are welcome.

Dr. Antonella Galeone
Guest Editor

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• cardiac transplantation
• primary graft failure
• mechanical circulatory support
• left ventricular assist device
• allograft rejection
• cardiac allograft vasculopathy
• quality of life
• xenotransplantation
• machine perfusion
• donation after circulatory death