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Medicina
Special Issues
Blood Diseases and Public Health
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Blood Diseases and Public Health

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Hematology and Immunology".

Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 1488

Special Issue Editors

Dr. Cristina Mambet

E-Mail Website1 Website2
Guest Editor
1. Department of Hematology, Emergency University Hospital of Bucharest, “Carol Davila” University of Medicine and Pharmacy, 050098 Bucharest, Romania
2. Department of Cellular and Molecular Pathology, "Stefan S. Nicolau Institute of Virology", 030304 Bucharest, Romania
Interests: myeloid neoplasms; molecular basis; genetic predisposition; non-invasive biomarkers; targeted therapies
Prof. Dr. Ana Maria Vladareanu

E-Mail Website1 Website2
Guest Editor
Department of Hematology, Emergency University Hospital of Bucharest, “Carol Davila” University of Medicine and Pharmacy, 050098 Bucharest, Romania
Interests: myeloid neoplasms; molecular basis; genetic predisposition; non-invasive biomarkers; targeted therapies; hematologic diseases

Special Issue Information

Dear Colleagues,

Hematological malignancies represent a heterogeneous group of cancers that originate in bone-marrow-derived cells. These distinct neoplastic diseases are the fifth most common type of cancer, with about 1.24 million new cases diagnosed annually worldwide. Their impact on global mortality is substantial, accounting for more than 7% of cancer deaths worldwide.

According to the classification provided by the World Health Organization in 2022, more than 100 blood cancer subtypes are currently described. The main categories of hematological cancers include leukemias, lymphomas, multiple myeloma, as well as myeloproliferative neoplasms (MPN), myelodysplastic neoplasms (MDS), and diseases with overlapping features of myeloproliferation and dysplasia (MDS/MPN). They are characterized by various clinical, histopathologic, and genetic patterns that influence prognosis and therapeutic response.

Due to the illness-related complications and the side effects of intensive therapeutic protocols, with infections being a frequent problem, patients diagnosed with a type of blood cancer often require prolonged and expensive hospitalization.

New therapeutic approaches, including targeted therapy drugs, become available either as an approved treatment option or in clinical trials for patients with hematological malignancies, aiming to improve the survival rate and increase the quality of life.

We invite specialists in the field of hematology to submit original research articles or reviews concerning the advances in the diagnosis, prognostication, treatment, and monitoring of blood cancers.

Dr. Cristina Mambet
Prof. Dr. Ana Maria Vladareanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • molecular landscape of hematological malignancies

  • genomic and proteomic biomarkers for risk stratification and personalized treatment
  • new pharmacological approaches in blood cancer therapy
  • diagnostic and therapeutic challenges in particular types of hematological cancers
  • the role of chronic inflammation in blood cancers
  • familial blood cancers

Published Papers (1 paper)

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8 pages, 2148 KiB  
Case Report
Lung Involvement in Adult T-Cell Lymphoma Diagnosed Using Bronchoscopic Cryobiopsy: A Case Report and Review of the Literature
by Yasuhiro Tanaka, Takashi Kido, Noriho Sakamoto, Atsuko Hara, Takeharu Kato, Ritsuko Miyashita, Mutsumi Ozasa, Takatomo Tokito, Daisuke Okuno, Kazuaki Takeda, Hirokazu Yura, Shinnosuke Takemoto, Takahiro Takazono, Hiroshi Ishimoto, Yasushi Obase, Yuji Ishimatsu, Yasushi Miyazaki and Hiroshi Mukae
Medicina 2023, 59(11), 2015; https://doi.org/10.3390/medicina59112015 - 16 Nov 2023
Viewed by 1097
Abstract
The diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. Moreover, pulmonary involvement in adult T-cell lymphoma (ATL) is often difficult to diagnose, especially in cases without characteristic flower [...] Read more.
The diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. Moreover, pulmonary involvement in adult T-cell lymphoma (ATL) is often difficult to diagnose, especially in cases without characteristic flower cells. Here, we present the case of a 78-year-old man, in whom pathological examination of the transbronchial lung biopsy (TBLB) specimen did not reveal malignant findings; therefore, transbronchial lung cryobiopsy (TBLC) in combination with endobronchial ultrasonography (EBUS) was used to diagnose ATL based on the pathological findings. A literature review identified 18 cases of pulmonary lymphomas diagnosed using TBLC. Among the 19 cases, including our own, 16 cases were of B-cell lymphoma (84.2%), and the present case is the first case of ATL diagnosed using TBLC. Eighty percent of the cases underwent a biopsy (more than two samples) of the middle or lower lobe and were diagnosed without major complications. EBUS was used with TBLC in three cases to identify the location of the pulmonary lesions. In the present case, EBUS was also useful for avoiding vascular biopsy. Although large-scale prospective studies are required to establish precise guidelines for diagnosing pulmonary lymphomas using TBLC, our case report and review contributes to a deeper understanding of the diagnosis of rare diseases. Full article
(This article belongs to the Special Issue Blood Diseases and Public Health)
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