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Updates on Pancreatic Diseases: A Surgical and Multidisciplinary Approach

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Special Issue Editors

Dr. Valentina Valle

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Guest Editor

Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: robotic surgery; pancreatic surgery

Dr. Alberto Mangano

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Guest Editor

Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: robotic surgery; minimally invasive surgery; abdominal surgery; colorectal surgery; surgical oncology; general surgery; surgery; meta-analysis; systematic reviews; gastrointestinal surgery

Special Issue Information

Dear Colleagues,

Historically, pancreatic surgery has been considered a "major" procedure that carries risks of complications, high morbidity, and short/long-term negative outcomes. It has always represented a challenge for the surgeon due to the technical complexity of the different techniques, including resections in proximity of the major vessels and problems associated with the reconstruction phase.

These are some of the reasons as to why pancreatic surgery continues to be technically challenging and requires significant experience despite the surgical approach (open vs laparoscopic vs robotic) adopted. Pancreatic surgery, to guarantee the best outcomes, must be performed by skilled surgeons in high-volume and high-expertise referral centers.

Recently, both the indications and the techniques of pancreatic surgery have been evolving, for example, considering the parenchyma-preserving resections for benign lesions at high risk of malignant transformation. A multidisciplinary approach is needed for accurate decision-making, based on the presumed diagnosis, tumor location, surgical risk, and medical history.

The purpose of this Special Issue is to discuss heterogenous but inter-related matters associated with benign and malignant pancreatic disease management. This Special Issue will have a specific focus on the state of the art of the different surgical approaches, on updates about evidence-based guidelines while also presenting rare/educational cases and discussing multidisciplinary strategies for pancreatic diseases and the potential future perspectives.

Dr. Valentina Valle
Dr. Alberto Mangano
Guest Editors

Manuscript Submission Information

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Keywords

pancreatic surgery
pancreatic cancer
pancreatitis
pancreatoduodenectomy
robotic pancreatic surgery
pancreatectomy
complications in pancreatic surgery
HPB surgery
pancreatic benign diseases

Published Papers (2 papers)

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Research

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15 pages, 1798 KiB

Open AccessArticle

Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats

by Panagoula Oikonomou, Christina Nikolaou, Fotini Papachristou, Apostolos Sovatzidis, Maria Lambropoulou, Charikleia Giouleka, Vasileios Kontaxis, Dimitrios Linardoutsos, Apostolos Papalois, Michael Pitiakoudis and Alexandra Tsaroucha

Medicina 2024, 60(1), 74; https://doi.org/10.3390/medicina60010074 - 30 Dec 2023

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Abstract

Background and Objectives: Inflammation and dysregulation in the intestinal barrier function in acute pancreatitis (AP) trigger pancreatic lesions, systemic inflammatory response, and multiple organ dysfunction. Eugenol, as the main component of clove (Syzygium aromaticum), is known for its antioxidant and anti-inflammatory properties. We studied the potentially beneficial effect of eugenol in a rodent model of biliopancreatic duct ligation-induced AP. Materials and Methods: Rats were randomly divided into three groups: Sham, AP, and AP + eugenol (15 mg/kg/day). Serum TNFα, IL-6, IL-18, and resistin levels, as well as IL-6, TNFα, MPO, HMGB1, and CD45 tissue expression, were determined at various timepoints after the induction of AP. Results: Eugenol attenuated hyperemia and inflammatory cell infiltration in the intestinal mucosal, submucosal, and muscular layers. IL-6 and resistin serum levels were significantly reduced in the AP + eugenol group, while serum TNFα and IL-18 levels remained unaffected overall. TNFα pancreatic and intestinal expression was attenuated by eugenol at 72 h, while IL-6 expression was affected only in the pancreas. MPO, CD45, and HMGB1 intestinal expression was significantly reduced in eugenol-treated rats. Conclusions: Eugenol managed to attenuate the inflammatory response in the intestine in duct ligation-induced AP in rats. Full article

(This article belongs to the Special Issue Updates on Pancreatic Diseases: A Surgical and Multidisciplinary Approach)

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10 pages, 3991 KiB

Open AccessCase Report

Pancreaticoduodenectomy with Anatomical Vascular Variant in Groove Pancreatitis—A Case Report

by Gelu M. Breaza, Radu G. Dan, Florin E. Hut, Flavia Baderca, Octavian M. Cretu and Laurentiu V. Sima

Medicina 2024, 60(4), 626; https://doi.org/10.3390/medicina60040626 - 12 Apr 2024

Viewed by 643

Abstract

Groove pancreatitis represents a chronic focal form of pancreatitis affecting the zone between the pancreatic head and the duodenal “C” loop, known as the groove area. This is a rare condition that affects the pancreatic periampullary part, including the duodenum and the common bile duct, which is usually associated with long-term alcohol and tobacco misuse, and is more frequent in men than in women. The most common clinical symptoms of groove pancreatitis include weight loss, acute abdominal pain, nausea, and jaundice. This report is about a 66-year-old woman with a history of heavy smoking, presenting with weight loss, nausea, and upper abdominal pain. Contrast-enhanced computed tomography revealed the existence of chronic pancreatitis as well as the dilatation of the main pancreatic duct, a cyst of the pancreatic head, and enlargement of the biliary tract. Conservatory treatment was initiated but with no improvement of symptoms. Since endoscopic retrograde cholangiopancreatography was not possible due to the local changes, we decided to perform pancreatoduodenectomy, as surgery appears to be the single effective treatment. Full article

(This article belongs to the Special Issue Updates on Pancreatic Diseases: A Surgical and Multidisciplinary Approach)

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