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Medicina
Special Issues
Epidemiology, Evaluation, and Treatment of Necrotizing Soft Tissue Infection
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Epidemiology, Evaluation, and Treatment of Necrotizing Soft Tissue Infection

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2999

Special Issue Editors

Dr. John O. Hwabejire

E-Mail Website
Guest Editor
Massachusetts General Hospital, Boston, MA, USA
Interests: necrotizing soft tissue infection; Fournier’s gangrene; debridement; LRINEC score; tissue necrosis; bacterial infection; epidemiology; polymicrobial infection; gas gangrene; Clostridial myonecrosis
Dr. Hassan N. Mashbari

E-Mail Website
Co-Guest Editor
1. Massachusetts General Hospital, Boston, MA, USA
2. Department of Surgery, Jazan University, Jazan, Saudi Arabia
Interests: critical care medicine; hip fracture; surgery
Dr. Christine E. Nembhard

E-Mail
Co-Guest Editor
Howard University Hospital, Washington, DC, USA
Interests: injury severity score; blunt traumatic; geriatrics

Special Issue Information

Dear Colleagues,

Necrotizing soft tissue infection (NSTI) is a severe, rapidly progressing, necrotic bacterial infection involving the soft tissues of the body. Aptly described as the “flesh-eating bacterial infection”, this disease has a long and storied history. It was described by Hippocrates around the 5th century BC as a disease in which “many were attacked by the erysipelas all over the body when the exciting cause was a trivial accident flesh, sinews, and bones fell away in large quantities there were many deaths”. It has been variously named “hospital gangrene”, Fournier’s gangrene, and necrotizing fasciitis.

Despite the recognition of the disease many millennia ago, NSTI remains a devastating disease with extremely high morbidity and mortality. Its incidence is increasing globally. In the treatment of necrotizing soft tissue infection, the most important predictor of outcome is time: time to diagnosis, surgical debridement, and the initiation of antibiotic therapy.

With the same urgency, we invite our colleagues from around the world to contribute manuscripts that address the epidemiology, evaluation, and treatment of necrotizing soft tissue infection. The collected knowledge in this Special Issue of Medicina will disseminate critical information that will contribute to save lives around the world from this killer disease.

Dr. John O. Hwabejire
Dr. Hassan N. Mashbari 
Dr. Christine E. Nembhard
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • necrotizing soft tissue infection
  • Fournier’s gangrene
  • debridement
  • LRINEC score
  • tissue necrosis
  • bacterial infection
  • epidemiology
  • polymicrobial infection
  • gas gangrene
  • clostridial myonecrosis

Published Papers (1 paper)

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16 pages, 998 KiB  
Systematic Review
Necrotizing Fasciitis—Severe Complication of Bullous Pemphigoid: A Systematic Review, Risk Factors, and Treatment Challenges
by Milan Stojičić, Milana Jurišić, Milana Marinković, Miodrag Karamarković, Milan Jovanović, Jelena Jeremić, Marko Jović, Aleksandar Vlahović, Mladen Jovanović, Kristina Radenović, Nikola Jovićević and Dolika Vasović
Medicina 2023, 59(4), 745; https://doi.org/10.3390/medicina59040745 - 11 Apr 2023
Cited by 1 | Viewed by 2579
Abstract
Background and objectives: Bullous pemphigoid (BP), the most common subepidermal autoimmune skin blistering disease (AIBD) has an estimated annual incidence of 2.4 to 42.8 new cases per million in different populations, designating it an orphan disease. Characterized by disruption of the skin barrier [...] Read more.
Background and objectives: Bullous pemphigoid (BP), the most common subepidermal autoimmune skin blistering disease (AIBD) has an estimated annual incidence of 2.4 to 42.8 new cases per million in different populations, designating it an orphan disease. Characterized by disruption of the skin barrier combined with therapy-induced immunosuppression, BP could pose a risk for skin and soft tissue infections (SSTI). Necrotizing fasciitis (NF) is a rare necrotizing skin and soft tissue infection, with a prevalence of 0.40 cases per 100,000 to 15.5 cases per 100,000 population, often associated with immunosuppression. Low incidences of NF and BP classify them both as rare diseases, possibly contributing to the false inability of making a significant correlation between the two. Here, we present a systematic review of the existing literature related to the ways these two diseases correlate. Materials and methods: This systematic review was conducted according to the PRISMA guidelines. The literature review was conducted using PubMed (MEDLINE), Google Scholar, and SCOPUS databases. The primary outcome was prevalence of NF in BP patients, while the secondary outcome was prevalence and mortality of SSTI in BP patients. Due to the scarcity of data, case reports were also included. Results: A total of 13 studies were included, six case reports of BP complicated by NF with six retrospective studies and one randomized multicenter trial of SSTIs in BP patients. Conclusions: Loss of skin integrity, immunosuppressive therapy, and comorbidities commonly related to BP patients are risk factors for necrotizing fasciitis. Evidence of their significant correlation is emerging, and further studies are deemed necessary for the development of BP-specific diagnostic and treatment protocols. Full article
(This article belongs to the Special Issue Epidemiology, Evaluation, and Treatment of Necrotizing Soft Tissue Infection)
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