Precision Medicine Approach in Septic Patients

Dear Colleagues,

We invite you to contribute to this Special Issue on the topic of sepsis in the context of precision medicine, focussing on the follow questions: what have we learned from evidence-based medicine? What are its limits, and what benefits are we expecting to gain from precision medicine?

Sepsis is one of the most prevalent pathologies in critically ill patients, which, despite well-established guidelines, causes high morbidity and mortality rates worldwide.

The main difficulty in the diagnosis and treatment of sepsis is the tremendous heterogeneity of this condition. The heterogeneity that characterizes sepsis ranges from its clinical presentation to the biological aspects of the disease. Guideline-based medicine approaches involve the treatment of a homogenous syndrome, regardless of the individual discrepancies between patients with sepsis, for whom these approaches may confer poor outcomes.

In recent years, personalized medicine has gained significant interest. The importance of understanding the genetic, epigenetic, and molecular basis of this condition is a of paramount importance in the tailoring of approaches to patients. The study of “omics”, such as cytomics, genomics, epigenomics, transcriptomics, proteomics, and metabolomics, provides a deeper comprehension of the complex interactions between the host, the disease, and the environment.

This Special Issue aims to gather valuable materials (original articles, reviews, and case reports) regarding the potential role of a personalized approach in sepsis management, considering the interactions between various “omics” and clinical phenotypes.

Dr. Gabriela Droc
Guest Editor

Dr. Sebastian Isac
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• sepsis
• septic shock
• precision medicine
• epigenomics
• cytomics
• genomics
• proteomics
• metabolomics
• transcriptomics