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Medicina
Special Issues
Hip and Knee Surgery: Latest Advances and Prospects
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Hip and Knee Surgery: Latest Advances and Prospects

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 15 November 2026 | Viewed by 634

Special Issue Editors

Dr. Andrei Marian Feier

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Guest Editor
Department of Orthopaedics and Traumatology, Clinical County Hospital, 540139 Tîrgu Mureș, Romania
Interests: orthopedics; basic orthopedics science; clinical orthopedics; medical orthopedics; orthopedic surgery; total knee replacement; knee implants; orthopedic sports medicine; sports surgery; stem cells; mesenchymal stem cells; healthcare
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mihai Dan Roman

E-Mail Website
Guest Editor
Surgical Department, Faculty of Medicine, University “Lucian Blaga” of Sibiu, 550024 Sibiu, Romania
Interests: orthopedics; orthopedic surgery and traumatology; knee and hip injuries; knee surgery; arthroplasty sports injuries; fracture cartilage trauma surgery; knee replacement arthroplasties; shoulders; rotator cuff
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tudor Sorin Pop

E-Mail Website
Guest Editor
Department of Orthopaedics and Traumatology, Clinical County Hospital, 540139 Tîrgu Mureș, Romania
Interests: hip; knee; bone orthopedics; arthroplasty fracture; knee surgery; hip arthroplasty; hip and knee arthroplasty; knee arthroplasty
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue invites contributions that reflect contemporary surgical practice involving the hip and knee. While a central focus remains on total hip replacement and total knee replacement, we also welcome submissions addressing other procedures. Topics of interest include osteotomies, cartilage repair, multi-ligament reconstruction, revision strategies and outcomes, management of periprosthetic fractures, and treatment of early-onset degenerative conditions. Studies investigating surgical approaches, perioperative protocols, imaging-based planning, and patient-specific instrumentation are encouraged. We are particularly interested in work that passes or combines technical innovation with meaningful clinical outcomes. This Special Issue seeks to capture both established practices and emerging techniques in hip and knee surgery. We welcome original research, clinical series, comparative trials, case reports, and systematic reviews that enhance understanding of current standards, complications, and future directions in joint-preserving and joint-replacing procedures alike.

Dr. Andrei Marian Feier
Prof. Dr. Mihai Dan Roman
Prof. Dr. Tudor Sorin Pop
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • knee arthroplasty
  • hip replacement
  • periprosthetic fracture management
  • surgical cartilage repair
  • high tibial osteotomy
  • hip and knee fractures

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Published Papers (1 paper)

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Research

15 pages, 1361 KB  
Article
Synovial Fluid as a Window into Early Cartilage Remodeling After Autologous Matrix-Induced Chondrogenesis
by Adrian Urbanek, Maciej Wrotniak, Paweł Dolibog, Zenon Czuba, Grzegorz Pilecki, Marcin Kostuj, Paulina Zalejska-Fiolka, Łukasz Polczak, Aleksandra Roubo-Urbanek, Marcin Hajzyk and Jolanta Zalejska-Fiolka
Medicina 2026, 62(5), 922; https://doi.org/10.3390/medicina62050922 (registering DOI) - 9 May 2026
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Abstract
Background and Objectives: Autologous matrix-induced chondrogenesis (AMIC) is an established technique for the treatment of focal cartilage defects of the knee, with well-documented clinical outcomes. However, the biological processes underlying early postoperative cartilage remodeling remain poorly characterized, and the role of synovial [...] Read more.
Background and Objectives: Autologous matrix-induced chondrogenesis (AMIC) is an established technique for the treatment of focal cartilage defects of the knee, with well-documented clinical outcomes. However, the biological processes underlying early postoperative cartilage remodeling remain poorly characterized, and the role of synovial fluid biomarkers in this setting is not well defined. This study aimed to assess short-term changes in selected synovial fluid and serum biomarkers of cartilage turnover after AMIC and to examine their associations with clinical outcomes. Materials and Methods: Fifteen patients undergoing AMIC for focal knee chondral or osteochondral defects were prospectively enrolled. Synovial fluid and serum samples were collected intraoperatively and at 6 and 12 weeks postoperatively. Concentrations of matrix metalloproteinase-3 (MMP-3), tissue inhibitor of metalloproteinases-2 (TIMP-2), cartilage oligomeric matrix protein (COMP), and procollagen type II C-terminal propeptide (PIICP) were measured using multiplex flow luminescence immunoassay. Clinical outcomes were evaluated using the International Knee Documentation Committee (IKDC) and Lysholm scores preoperatively and at 6 and 12 months. Results: Both IKDC and Lysholm scores improved significantly during follow-up. Absolute biomarker concentrations in synovial fluid were low and did not change significantly over time. Nevertheless, higher MMP-3 levels, higher COMP concentrations, and a higher MMP-3/TIMP-2 ratio were associated with poorer clinical improvement. Correlations between synovial fluid and serum biomarker levels were generally weak. Total synovial fluid protein increased postoperatively but did not account for the low biomarker concentrations. Conclusions: Early biomarker profiles after AMIC were characterized by low absolute concentrations without significant temporal changes. However, associations of COMP, MMP-3, and the MMP-3/TIMP-2 ratio with clinical outcomes suggest that relative biomarker patterns may reflect early intra-articular remodeling. Synovial fluid analysis may provide more informative insight into local joint biology than serum measurements in this setting. These findings should be interpreted cautiously and require confirmation in larger cohorts. Full article
(This article belongs to the Special Issue Hip and Knee Surgery: Latest Advances and Prospects)
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