Epidemiology, Mechanisms, and Treatment of Sarcopenia and Associated Metabolic Diseases

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Endocrinology".

Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 2353

Special Issue Editors

Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
Interests: tissue engineering; biomaterials; stem cells; regenerative medicine; osteoarthritis; sarcopenia

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Guest Editor
Department of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China
Interests: sports training; biomedicine; materials

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Guest Editor
Xiangya Nursing School, The Central South University, Changsha, China
Interests: sarcopenia; aging; senile diseases

Special Issue Information

Dear Colleagues,

Sarcopenia is a progressive, widespread skeletal muscle disorder associated with an increased likelihood of adverse outcomes such as falls, fractures, physical disability, and death. Sarcopenia is associated with several metabolic diseases including obesity, hypertension, diabetes, etc. and it has similarities in pathogenesis (insulin resistance mainly) and its treatment (exercise, nutrition, drugs, etc.). When different criteria are used to define sarcopenia, there is a large variation in the reported prevalence between studies or even within studies, so the prevalence of sarcopenia is difficult to compare. But with the release of the consensus of the individual sarcopenia working groups, an increasing number of studies use established definitions, which allows some comparison of the prevalence across different studies. With the aging of the population, sarcopenia has become an increasingly serious health problem, which has been highly concerned by the country and the people. Paying attention to the early screening and prevention of sarcopenia in the elderly can improve the quality of life of the elderly and reduce the burden of society and families.

This research topic aims to highlight the sarcopenia and its associated metabolic diseases in a cross-over study. We specifcally focus on pathogenesis, pathological pathogenic changes, and its epidemiology. Additionally, we will reflect on exercise, nutrition, pharmacotherapy and other interventions to sarcopenia in aging and comorbidities.

This Research Topic welcomes submissions ranging from Original, Clinical, and Translational articles and Reviews in the field of Sarcopenia and Associated Metabolic Diseases. 

Dr. Yusheng Li
Prof. Dr. Yuxiang Wu
Prof. Dr. Xiuhua Wang
Guest Editors

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Keywords

  • sarcopenia
  • epidemiology
  • mechanisms
  • treatment
  • metabolic diseases
  • muscle
  • burden
  • aging

Published Papers (1 paper)

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Research

12 pages, 330 KiB  
Article
The Prevalence of Sarcopenia among Hunan Province Community-Dwelling Adults Aged 60 Years and Older and Its Relationship with Lifestyle: Diagnostic Criteria from the Asian Working Group for Sarcopenia 2019 Update
by Jing Zhong, Wenqing Xie, Xiaoqin Wang, Xin Dong, Yihan Mo, Dan Liu, Xuemei Yao, Beibei Liu, Wenyu Deng, Yidong Su, Yusheng Li and Xiuhua Wang
Medicina 2022, 58(11), 1562; https://doi.org/10.3390/medicina58111562 - 30 Oct 2022
Cited by 3 | Viewed by 1877
Abstract
Background and Objectives: This study aims to detect the prevalence of sarcopenia in community-dwelling older adults in Hunan Province, discuss factors related to lifestyle, and provide a reliable basis for the prevention and treatment of sarcopenia. Materials and Methods: In this [...] Read more.
Background and Objectives: This study aims to detect the prevalence of sarcopenia in community-dwelling older adults in Hunan Province, discuss factors related to lifestyle, and provide a reliable basis for the prevention and treatment of sarcopenia. Materials and Methods: In this study, a total of 1040 community-dwelling adults ≥ 60 years were examined for sarcopenia using a cluster stratified random sampling method, which was defined using the diagnostic criteria recommended by the Asian Working Group for Sarcopenia (AWGS) from September 2019 to March 2020. Multivariate logistic regression analysis was applied to determine the correlation between sarcopenia and smoking, drinking, nutritional status, physical activity, and sleep quality. Results: A total of 27.1% of the older adults were diagnosed with sarcopenia, with rates of 26.2% in men and 25.2% in women. Multiple logistic regression showed that advanced age (OR = 2.480, 95% CI: 1.730, 3.553), the risk of malnutrition (OR = 2.085, 95% CI: 1.440, 3.019), and malnutrition (OR = 1.212, 95% CI: 0.304, 4.834) were risk factors for sarcopenia. No falls in the previous year (OR = 0.616, 95% CI: 1.885, 1.209), normal weight (OR = 0.228, 95% CI: 0.109, 0.475), overweight (OR = 0.030, 95% CI: 0.013, 0.069), moderate physical activity (OR = 0.593, 95% CI: 0.377, 0.933), or high physical activity (OR = 0.417, 95% CI: 0.230, 0.755) were identified as protective factors for sarcopenia. Conclusions: The prevalence of sarcopenia was high among older adults in the community in Hunan Province. In addition, we found that lifestyle is an important factor in sarcopenia. Full article
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