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Medicina
Special Issues
Impact of Anesthetics on Cancer Behavior and Outcome
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Impact of Anesthetics on Cancer Behavior and Outcome

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 5846

Special Issue Editors

Dr. Alain Borgeat

E-Mail Website
Guest Editor
Balgrist Campus, Lengghalde 5, 8008 Zurich, Switzerland
Interests: regional anesthesia; peri and postoperative pain; cancer recurrence
Dr. Jose A. Aguirre

E-Mail Website
Guest Editor
Balgrist Univ Hosp, Div Anesthesiol, Forchstr 340, CH-8008 Zurich, Switzerland
Interests: regional anesthesia; peri and postoperative pain; cancer recurrence

Special Issue Information

Dear Colleagues, 

Background and history of this topic: Clinical and basic science studies have demonstrated the antiinflammatory properties of local anesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. The potential beneficial effects of regional anesthesia have been attributed mainly to the inhibition of the neuroendocrine stress response to surgery and to the reduction in the requirements of volatile anesthetics and opioids. Because cancer is linked to inflammation and local anesthetics have anti-inflammatory effects, these agents may participate in reducing the risk of metastasis, buth their mechanism of action is unknown. We demonstrated in vitro that amide local anesthetics attenuate tumor cell migration as well as signaling pathways enhancing tumor growth and metastasis. This has provided the first evidence of a molecular mechanism by which regional anesthesia might inhibit or reduce cancer metastases.

Aim and scope of the special issue: To summarize the most recent evidence of how drugs used in anesthesia can or cannot influence cancer behavior and outcome

Cutting edge research: This issue will collect and display the biomolecular and gene expression findings associated with the infusion of local anesthetics in this context.

Dr. Alain Borgeat
Dr. Jose A. Aguirre
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • local anesthetics
  • cancer behavior
  • biomolecular mechanisms
  • gene expression

Published Papers (3 papers)

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Review

6 pages, 257 KiB  
Review
General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep
by John Michael Bonvini
Medicina 2022, 58(9), 1156; https://doi.org/10.3390/medicina58091156 - 25 Aug 2022
Viewed by 1522
Abstract
Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread. With the perioperative period increasingly becoming a focus of research in anesthesia, anesthesiologists have looked [...] Read more.
Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread. With the perioperative period increasingly becoming a focus of research in anesthesia, anesthesiologists have looked at the chance to influence cancer progression based on their choice of anesthesia regimen and strategy. Many anesthetic agents have been investigated for their potential impact on the course of cancer disease. There is an abundance of retrospective studies and very few prospective ones that tackled this issue. The aim of this article is to review the current state of the evidence on general anesthesia involving volatile and intravenous agents as substrates, focusing on halogenated inhalational agents and propofol, to guide clinical decision making in assessments of the best practice for perioperative management of cancer surgery. Full article
(This article belongs to the Special Issue Impact of Anesthetics on Cancer Behavior and Outcome)
19 pages, 542 KiB  
Review
Anesthetics and Long Term Cancer Outcomes: May Epigenetics Be the Key for Pancreatic Cancer?
by Zhirajr Mokini, Alessandro Cama and Patrice Forget
Medicina 2022, 58(8), 1102; https://doi.org/10.3390/medicina58081102 - 14 Aug 2022
Cited by 1 | Viewed by 2187
Abstract
Knowledge shows a divergence of results between preclinical and clinical studies regarding anesthesia and postoperative progression of cancer. While laboratory and animal data from then 2000s onwards raised much enthusiasm in this field of research leading to several clinical investigations worldwide, data from [...] Read more.
Knowledge shows a divergence of results between preclinical and clinical studies regarding anesthesia and postoperative progression of cancer. While laboratory and animal data from then 2000s onwards raised much enthusiasm in this field of research leading to several clinical investigations worldwide, data from randomized trials seem to have killed off hope for many scientists. However several aspects of the actual knowledge should be reevaluated and there is space for new strategies of investigation. In this paper, we perform a critical review of actual knowledge and propose new research strategies with a special focus on anesthetic management and repurposed anesthetic adjuvants for pancreatic cancer. Full article
(This article belongs to the Special Issue Impact of Anesthetics on Cancer Behavior and Outcome)
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9 pages, 478 KiB  
Review
Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
by Alain Borgeat and José Aguirre
Medicina 2022, 58(7), 882; https://doi.org/10.3390/medicina58070882 - 30 Jun 2022
Cited by 2 | Viewed by 1755
Abstract
There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown [...] Read more.
There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhibit the Intercellular Adhesion Molecule 1 (ICAM-1) expression and Src activity, which are clearly implicated in the process of inflammation and cancer metastases. This review emphasizes the potential of amide-type local anesthetics in this context. Full article
(This article belongs to the Special Issue Impact of Anesthetics on Cancer Behavior and Outcome)
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