Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.3
2.4
Journals
Medicina
Special Issues
Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives
share announcement

Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 671

Special Issue Editors

Dr. Marco Massani

E-Mail Website
Guest Editor
HPB Hub Reference Center, First General Surgery Unit, Department of Surgery, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, Italy
Interests: pancreas; liver; HCC; cholangiocarcinoma; minimally invasive liver and pancreatic surgery; blunt liver and splenic trauma; CT-HAI; liver volumetry; ICG; colorectal surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Tommaso Stecca

E-Mail Website
Guest Editor
HPB Hub Reference Center, First General Surgery Unit, Department of Surgery, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, Italy
Interests: HPB; cholangiocarcinoma; hepatocarcinoma; hepatic arterial infusion pump chemotherapy; colorectal liver metasases; radiomics; emergency surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to participate in this Special Issue of the JCM, “Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives”.

Modern hepatobiliopancreatic surgery, while employing surgical techniques that have been consolidated over decades of use, is increasingly making use of new tools both in surgical practice and in patient evaluation and modern oncological therapies.

The purpose of this Special Issue is to present to the scientific community the latest innovations in hepatobiliopancreatic surgery.

In this Special Issue, we invite authors to submit manuscripts on recent updates and challenges in the surgical management of HPB disease. Articles are welcome that deal with both mere surgical technique, technology, and artificial intelligence in the pre-, intra-, and post-operative workup, new instruments, and new loco-regional or systemic therapies.

Dr. Marco Massani
Dr. Tommaso Stecca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPB surgery
  • liver cancer
  • pancreatic cancer
  • biliary tract cancer

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 535 KiB  
Article
Utilizing Albumin Value, HALP Score and LCR Value for Predicting Survival in Patients with Pancreatic Adenocarcinoma
by Tufan Gumus, Veysel Umman, Bekir Cetin and Alper Uguz
Medicina 2025, 61(4), 639; https://doi.org/10.3390/medicina61040639 - 1 Apr 2025
Viewed by 70
Abstract
Background and Objectives: This study aimed to determine whether albumin levels and the ratios of key biochemical markers, including the hemoglobin, albumin, lymphocyte, and platelet (HALP score) and lymphocyte/C-reactive protein ratio (LCR), can predict survival and recurrence in patients with pancreatic adenocarcinoma. [...] Read more.
Background and Objectives: This study aimed to determine whether albumin levels and the ratios of key biochemical markers, including the hemoglobin, albumin, lymphocyte, and platelet (HALP score) and lymphocyte/C-reactive protein ratio (LCR), can predict survival and recurrence in patients with pancreatic adenocarcinoma. Materials and Methods: A total of 87 patients who underwent surgery for pancreatic adenocarcinoma in our clinic between January 2017 and December 2021 were included. Preoperative albumin levels, HALP scores, and LCR values were calculated and analyzed to evaluate their predictive value for pathological findings in the early postoperative period. Results: The mean age of the study population was 64.8 ± 9.6 years; 59 patients (67.8%) were male, and 28 (32.2%) were female. The cut-off values for HALP, LCR, and albumin were 34.4, 0.61, and 38.55, respectively. Patients with low HALP scores had significantly shorter overall survival than those with high scores (15.8 vs. 19.3 months; p < 0.01). Similarly, patients with low LCR scores showed shorter survival than those with high scores (17.8 vs. 18.5 months; p < 0.01). High albumin levels were associated with significantly longer survival compared to low albumin levels (16.3 vs. 14.6 months; p < 0.01). Conclusions: Low HALP scores and low albumin levels were identified as significant independent prognostic factors for both disease-free and overall survival in patients with pancreatic adenocarcinoma. Full article
(This article belongs to the Special Issue Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives)
►▼ Show Figures

Figure 1

9 pages, 1952 KiB  
Article
Development of an Immunodeficient Pig Model for Pancreatic Cancer Xenotransplantation Using Splenectomy, Thymectomy, and Oral Immunosuppression
by Jun Suh Lee, Yoo-Seok Yoon, Ho-Seong Han, Jai Young Cho, Hae-Won Lee, Boram Lee, Yeshong Park and MeeYoung Kang
Medicina 2025, 61(4), 586; https://doi.org/10.3390/medicina61040586 - 25 Mar 2025
Viewed by 188
Abstract
Background and Objectives: Animal models are widely used in medical research, but most are limited to small or medium-sized species due to logistical constraints. However, pancreatic cancer research and surgical xenograft models require large animals with anatomical similarities to humans and minimal [...] Read more.
Background and Objectives: Animal models are widely used in medical research, but most are limited to small or medium-sized species due to logistical constraints. However, pancreatic cancer research and surgical xenograft models require large animals with anatomical similarities to humans and minimal immune rejection. This study evaluates the feasibility of an operative immunodeficient pig model for patient-derived xenografts. Materials and Methods: During the period of October 2020 and October 2021, four pigs were used to establish a pig model at Seoul National University Bundang Hospital. A conventional pig 40 weeks of age was used. After introduction into the animal laboratory, splenectomy and thymectomy were performed to minimize B-cell and T-cell function. One week after the initial operation, oral immunosuppression was administered. After 4 weeks, human PDAC cells were implanted in the liver and pancreas. After 4 weeks of implant, the pigs were sacrificed, and the operative and pathologic findings were analyzed. Results: All four pigs survived the 9-week experiment. Indwelling venous catheters for drug-level monitoring were attempted but failed. Splenectomy and thymectomy were deemed to be feasible and effective. Oral immunosuppression was acceptable, but the initial dosage was better tolerated at low levels. Out of the four pigs, one pig showed a mass formation at the cell line injection site, demonstrating reactive cell clusters on pathology. Conclusions: This pig model using conventional pigs is a feasible model of immunosuppression. It is necessary to fine-tune the oral immunosuppression dosage and develop methods for the frequent monitoring of immunosuppression levels. Full article
(This article belongs to the Special Issue Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives)
►▼ Show Figures

Figure 1

16 pages, 299 KiB  
Article
Impact of Preoperative Biliary Stenting on Intestinal Dysfunction and Perioperative Complications After Pylorus-Preserving Pancreaticoduodenectomy
by Gelu Mihai Breaza, Florin Emil Hut, Octavian Cretu, Simona-Alina Abu-Awwad, Ahmed Abu-Awwad, Laurentiu Sima, Radu Gheorghe Dan, Cristina Ana-Maria Dan, Raluca Maria Closca and Flavia Zara
Medicina 2025, 61(3), 391; https://doi.org/10.3390/medicina61030391 - 24 Feb 2025
Viewed by 271
Abstract
Background and Objectives: Preoperative biliary stenting (PBS) is commonly used to manage obstructive jaundice in patients undergoing pylorus-preserving pancreaticoduodenectomy (PPPD). However, the impact of PBS on intestinal barrier function and perioperative complications remains controversial. This study aims to evaluate the effect of [...] Read more.
Background and Objectives: Preoperative biliary stenting (PBS) is commonly used to manage obstructive jaundice in patients undergoing pylorus-preserving pancreaticoduodenectomy (PPPD). However, the impact of PBS on intestinal barrier function and perioperative complications remains controversial. This study aims to evaluate the effect of PBS on intestinal dysfunction and surgical outcomes, focusing on the influence of the stent duration. Materials and Methods: In this prospective cohort study, 235 patients undergoing PPPD for resectable pancreatic neoplasms at Timișoara Municipal Emergency Clinical Hospital (2016–2024) were analyzed. Patients were divided into two groups: those with PBS (n = 98) and without PBS (n = 137). Intestinal barrier function was assessed pre- and postoperatively using biomarkers such as zonulin, fecal calprotectin, and serum lipopolysaccharides (LPS). Perioperative outcomes, including pancreatic fistula, delayed gastric emptying (DGE), infections, and hospital stay, were compared. Additionally, outcomes were stratified based on stent duration (2–3 weeks vs. 3–4 weeks). Results: PBS was associated with significantly higher levels of zonulin, fecal calprotectin, and serum LPS postoperatively, indicating compromised intestinal barrier function. The stented group had a higher incidence of pancreatic fistulas (Grade B/C: 27.5% vs. 13.1%, p < 0.01), DGE (25.5% vs. 13.1%, p = 0.008), postoperative infections (34.7% vs. 17.5%, p = 0.002), and prolonged hospital stay (16.9 ± 4.2 days vs. 14.5 ± 3.7 days, p = 0.019). Prolonged stenting (3–4 weeks) was associated with worse outcomes compared to shorter stenting durations (2–3 weeks), including increased rates of infections, sepsis, and ICU stay (p < 0.05 for all comparisons). Conclusions: Preoperative biliary stenting is associated with increased intestinal barrier dysfunction, systemic inflammation, and higher rates of perioperative complications following PPPD. Prolonged stenting durations (>3 weeks) further exacerbate these risks. Limiting the PBS duration to 2–3 weeks, alongside optimized perioperative management, may help reduce postoperative morbidity and improve surgical outcomes. Full article
(This article belongs to the Special Issue Hepato-Biliary-Pancreatic Surgery: Clinical Updates and Future Perspectives)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop