Cutting-Edge Research in Relapsed and Refractory Multiple Myeloma
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 491
Special Issue Editors
2. Faculty of Health Studies, University of Rijeka, Rijeka, Croatia
Interests: multiple myeloma; hematological malignancies
Special Issue Information
Dear Colleagues,
Multiple myeloma is one of the most common, incurable, malignant hematological diseases. However, treatment progress tends to be good, demonstrated by extended patient life spans.
Increasingly effective combinations of standard groups of drugs, such as proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, as well as the autologous transplantation of hematopoietic stem cells and improved supportive care have contributed to this progress.
Although disease remission after initial treatment is achieved in most patients, multiple myeloma is a disease prone to relapse. Each subsequent relapse, in principle, responds less well to therapy, and each subsequent remission period becomes shorter until the disease finally becomes resistant to any type of treatment.
The clinical manifestation of relapsed and refractory multiple myeloma is usually preceded by microenvironmental, cytogenetic, and molecular changes that lead to the production of new malignant plasma cell clones that have a better ability to grow and survive, as well as greater drug resistance.
In the treatment of relapsed and refractory multiple myeloma, there are great expectations from new immunotherapy modalities, such as bispecific antibodies and CAR T-cell therapy; the results of these in the treatment of severely overtreated patients are extremely promising.
Considering the growing scientific and clinical significance of relapsed and refractory multiple myeloma, the journal Medicina is launching this Special Issue titled "Cutting-Edge Research in Relapsed and Refractory Multiple Myeloma".
The aim of this Special Issue is to present and discuss all biological and clinical aspects of relapsed and refractory multiple myeloma, including epidemiology, diagnostics, antitumor and supportive treatment, and patient monitoring. Although the topic of this Special Issue is relapsed and refractory disease, high-quality and interesting papers dealing with newly diagnosed multiple myeloma will also be considered for publication.
We kindly invite all scientists and clinicians around the world to send their original papers, reviews or mini reviews, case series, and case reports that fit into the theme of this Special Issue and thus contribute to the dissemination of knowledge about this important and frequent hematological malignant disease.
Dr. Toni Valković
Dr. Sandra Bašić-Kinda
Guest Editors
Manuscript Submission Information
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Keywords
- multiple myeloma
- relapsed
- refractory
- biology
- microenvironment
- genetics
- diagnostic
- treatment
- clinical mainifestation
- outcome
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