Advances and Challenges in Kawasaki Disease

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: closed (20 June 2022) | Viewed by 6038

Special Issue Editor


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Guest Editor
1. Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
2. Hawaii Pacific Health Medical Group, Hawaii Pacific Health, Honolulu, HI, USA
Interests: Kawasaki disease; pediatric cardiology; electrophysiology; ECG analysis

Special Issue Information

Dear Colleagues,

Kawasaki disease continues to present as a diagnostic and therapeutic conundrum for pediatrics. More than 50 years after the first publication by Dr. Tomisaku Kawasaki, the etiology of the most common acquired heart disease of childhood is still a mystery. Kawasaki disease is an acute inflammatory disease of early childhood that presents with fever and a typical constellation of rash, lip erythema, conjunctival injection and lymphadenopathy. If left untreated, Kawasaki disease can result in coronary artery dilation, aneurysm formation, coronary thrombosis, and myocardial infarction in children and young adults.

Recent discoveries in basic science have been paramount to advancing our understanding of the genetics, molecular basis, cellular interactions, and pathophysiology of the disease. Translational and clinical studies have contributed to improved management guidelines with precise diagnostic algorithms and treatment options. These discoveries have been crucial in guiding clinicians to provide optimal care for patients, finding innovative therapeutic targets, and pioneering treatment algorithms to prevent disease progression with potentially fatal complications.

As a scientific community, we have a perpetual responsibility to advance our knowledge and available remedies for a particular disease and ultimately to contribute to the improvement of our patients’ quality of life. This is particularly true for Kawasaki disease. Future research and innovation in this field may reveal the etiology of the condition, develop sensitive and specific diagnostic tools for the disorder, better guide us in prognosticating the development of coronary artery lesions, and reveal effective therapeutic options to prevent coronary artery aneurysms.

This Special Issue on Kawasaki disease in Medicina sets out to solicit manuscripts summarizing novel research findings in the pathophysiology, diagnosis, prognosis, or management of Kawasaki disease. We would like to invite basic research scientists, epidemiologists, physicians (including infectious disease specialists, pediatricians, and cardiologists), and other scientists who have expertise and experience in studying an important aspect of Kawasaki disease to submit their manuscript for this Special Issue. We are looking for manuscripts that may provide an insight into yet unclear aspects of the pathophysiology; innovative diagnostic methods or algorithms facilitating early recognition of the disease or accurate prediction of the development of coronary aneurysms; novel treatment alternatives to shorten the inflammatory state or to decrease or even prevent the development of coronary artery lesions; and powerful prognostic tests for short or long-term sequelae.

I am honored to serve as a guest editor for this Special Issue on Kawasaki disease, and I am delighted to invite reports on cutting-edge science in basic, translational, or clinical research areas.

Dr. András Bratincsák
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Kawasaki disease
  • coronary artery dilation
  • aneurysm
  • myocardial infarction
  • inflammation

Published Papers (1 paper)

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Review

15 pages, 755 KiB  
Review
Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features
by Wendy Lee, Chooi San Cheah, Siti Aisyah Suhaini, Abdullah Harith Azidin, Mohammad Shukri Khoo, Noor Akmal Shareela Ismail and Adli Ali
Medicina 2022, 58(6), 734; https://doi.org/10.3390/medicina58060734 - 30 May 2022
Cited by 8 | Viewed by 5645
Abstract
Kawasaki disease (KD) has shown a marked increase in trend over the globe, especially within the last two decades. Kawasaki disease is often seen in the paediatric population below five years old, while it is rare for those who are beyond that age. [...] Read more.
Kawasaki disease (KD) has shown a marked increase in trend over the globe, especially within the last two decades. Kawasaki disease is often seen in the paediatric population below five years old, while it is rare for those who are beyond that age. Up to this date, no exact causes has been identified although KD was found more than half a century ago. The underlying pathogenesis of the disease is still unelucidated, and researchers are trying to unlock the mystery of KD. To further complicate the diagnosis and the prompt management, a specific biomarker for the diagnosis of KD is yet to be discovered, making it hard to differentiate between KD and other diseases with a similar presentation. Nonetheless, since its discovery, clinicians and scientists alike had known more about the different clinical aspects of typical KD. Thus, this article intends to revisit and review the various clinical manifestations and laboratory characteristics of KD in order to guide the diagnosis of KD. Full article
(This article belongs to the Special Issue Advances and Challenges in Kawasaki Disease)
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