Insights into Disease Mechanisms and Precision Treatment for Lysosomal Diseases
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Genetics and Molecular Medicine".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 317
Special Issue Editors
Interests: therapeutic discovery using biomaterials; lysosome and metabolic functions; pathogenesis of neurodegeneration
Interests: neuroinflammation; neurodegeneration; neuroimmunology; lysosome biology; receptor signalling; single-cell spatial analysis; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lysosomes play essential roles in catabolic pathways, the autophagy-lysosomal pathway, and signaling and are able to adapt to environmental stimuli. Lysosomal diseases are a group of disorders caused by lysosome functional deficiencies including loss of lysosomal enzyme activities and elevated lysosomal pH, which affect the degradation of biological macromolecules and cellular components. The accumulation of substrates, including lipids, cholesterol, and toxic protein aggregates, in the lysosomes can result in impairment of autophagy, aberrant vesicle trafficking, dysregulation of signaling pathways, and abnormal calcium homeostasis, as well as mitochondrial dysfunction. Dysfunctional lysosomes have been implicated in the pathogenesis of various diseases, including metabolic disorders, inflammatory diseases, and neurodegenerative diseases. The recent research focus has turned to the development of lysosomal probes as well as therapeutic strategies to modulate lysosomal function, including the use of small molecules, pharmacological chaperones, or nanoparticles.
This Special Issue aims to highlight the latest advances in novel therapeutic approaches for lysosomal diseases, new methods of detecting lysosome functions, and developments in methods or technologies to uncover disease mechanisms.
We invite authors to submit original articles and review articles regarding recent findings on lysosomal disease mechanisms, diagnosis, and therapeutic strategies.
Dr. Jialiu Zeng
Dr. Chih Hung Lo
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lysosomal enzymes
- lysosome acidification
- autophagy and metabolic functions
- neurodegeneration
- therapeutics development
- small molecule
- nanomedicine
- biomaterials
- crosstalk
- degradation
