Acute Kidney Injury Mechanisms: From Pathophysiology to Translational Therapeutics
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Urology & Nephrology".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 641
Special Issue Editors
Interests: pediatric nephrology; pediatrics; NICU; pediatric hepatology
Special Issue Information
Dear Colleagues,
Acute kidney injury (AKI) remains a major clinical challenge, contributing to high rates of morbidity, mortality, and progression to chronic kidney disease. Despite advances in supportive care, effective therapies to prevent or treat AKI remain limited. A deeper understanding of the complex mechanisms underlying AKI is essential for translating basic discoveries into innovative therapeutic strategies.
This Special Issue will focus on the cellular, molecular, and systemic mechanisms that drive AKI in diverse clinical contexts, including sepsis, ischemia–reperfusion, nephrotoxic injury, and cardiorenal syndromes. This Special Issue will also place emphasis on the study of pathways of inflammation, oxidative stress, mitochondrial dysfunction, cell death, microvascular injury, and maladaptive repair. Contributions exploring novel biomarkers, animal models, and translational approaches that bridge experimental findings with clinical application are strongly encouraged.
In addition, the Special Issue seeks to highlight the therapeutic potential of targeting key signalling pathways, immune responses, and regenerative processes. Studies investigating pharmacological interventions, cell-based therapies, and precision medicine approaches will provide valuable insights into future treatment options of AKI.
By bringing together original research articles, reviews, and perspectives, this Special Issue aims to serve as a platform for advancing the knowledge of AKI pathophysiology and for identifying novel therapeutic opportunities. Through this integrative effort, we hope to bridge the gap between bench and bedside, ultimately improving outcomes for patients affected by acute kidney injury.
Please feel free to contact us for any further clarification or information.
Dr. Nikolaos Gkiourtzis
Guest Editor Assistant
Dr. Despoina Tramma
Guest Editor
Manuscript Submission Information
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Keywords
- acute kidney injury
- pathophysiology
- inflammation
- oxidative stress
- mitochondrial dysfunction
- biomarkers
- translational research
- therapeutic development
- renal regeneration
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