Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.3
2.4
Journals
Medicina
Special Issues
Updates on Metastatic Renal Cell Carcinoma
share announcement

Updates on Metastatic Renal Cell Carcinoma

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2362

Special Issue Editor

Dr. Jakub Kucharz

E-Mail Website
Guest Editor
Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Interests: kidney Cancer; renal cell carcinoma; targeted therapy; urologic oncology; testicular cancer

Special Issue Information

Dear Colleagues,

Renal cell carcinoma (RCC) accounts for the vast majority of malignancies of the kidney, and its incidence is constantly increasing in developed countries.

While localized disease is associated with very good outcomes, patients with metastatic RCC (mRCC) face a worse prognosis. However, treatment options in that setting have undergone exceptional developments in recent decades. Many novel tyrosine kinase inhibitors and the introduction of immunotherapy, whether as a monotherapy or in combination with other drugs, have made an immense contribution to improving both the prognosis and quality of life of patients diagnosed with mRCC. What is also important, multiple lines of treatment with a variety of drugs are currently available. There are also significant roles played within local treatment in oligometastatic or oligoprogressive mRCC.

Certainly, there are still an exciting number of innovations yet to come, as many clinical trials are currently ongoing. Moreover, apart from the treatment options for patients with clear-cell RCC, there is also a promising advancement in understanding and treating the other, less common subtypes of RCC grouped together as non-ccRCC. Along with novel therapies, there has also been a significant improvement in understanding the biology of RCC. New predictive and prognostic factors are being developed, the role of the immune system is becoming better understood, and new perspectives for targeted therapies are continuously arising.

Taken together, all the developments in recent years and the perspectives for the future make for an exciting landscape of the modern approach to RCC.

We welcome the submission of original research papers and reviews.

Dr. Jakub Kucharz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • renal cell carcinoma
  • immunotherapy, targeted therapy
  • local treatment
  • radiation therapy

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 2376 KiB  
Article
Predictive Factors and the Role of Conventionally Fractionated Radiation Therapy for Bone Metastasis from Renal Cell Carcinoma in the Era of Targeted Therapy
by Hye Jin Kang, Myungsoo Kim, Yoo-Kang Kwak and So Jung Lee
Medicina 2024, 60(7), 1049; https://doi.org/10.3390/medicina60071049 - 26 Jun 2024
Viewed by 851
Abstract
Background and Objectives: Despite rapid advances in targeted therapies for renal cell carcinoma (RCC), bone metastases remain a major problem that significantly increases morbidity and reduces patients’ quality of life. Conventional fractionated radiotherapy (CF-RT) is known to be an important local treatment [...] Read more.
Background and Objectives: Despite rapid advances in targeted therapies for renal cell carcinoma (RCC), bone metastases remain a major problem that significantly increases morbidity and reduces patients’ quality of life. Conventional fractionated radiotherapy (CF-RT) is known to be an important local treatment option for bone metastases; however, bone metastases from RCC have traditionally been considered resistant to CF-RT. We aimed to investigate the effectiveness of CF-RT for symptomatic bone metastasis from RCC and identify the predictive factors associated with treatment outcomes in the targeted therapy era. Materials and Methods: Between January 2011 and December 2023, a total of 73 lesions in 50 patients treated with a palliative course of CF-RT for symptomatic bone metastasis from RCC were evaluated, and 62 lesions in 41 patients were included in this study. Forty-five lesions (72.6%) were treated using targeted therapy during CF-RT. The most common radiation dose fractionations were 30 gray (Gy) in 10 fractions (50%) and 39 Gy in 13 fractions (16.1%). Results: Pain relief was experienced in 51 of 62 lesions (82.3%), and the 12-month local control (LC) rate was 61.2%. Notably, 72.6% of the treatment course in this study was combined with targeted therapy. The 12-month LC rate was 74.8% in patients who received targeted therapy and only 10.9% in patients without targeted therapy (p < 0.001). Favorable Eastern Cooperative Oncology Group performance status (p = 0.026) and pain response (p < 0.001) were independent predictors of improved LC. Radiation dose escalation improved the LC in radiosensitive patients. A consistent treatment response was confirmed in patients with multiple treatment courses. Conclusions: CF-RT enhances pain relief and LC when combined with targeted therapy. Patients who responded well to initial treatment generally showed consistent responses to subsequent CF-RT for additional painful bone lesions. CF-RT could therefore be an excellent complementary local treatment modality for targeted therapy. Full article
(This article belongs to the Special Issue Updates on Metastatic Renal Cell Carcinoma)
►▼ Show Figures

Figure 1

18 pages, 817 KiB  
Article
Analysis of Factors Contributing to Adverse Events and Evaluation of Their Impact on Prognosis in Metastatic Renal Cell Carcinoma Patients—Real-World Experience in a Single-Center Retrospective Study and Narrative Review
by Piotr Domański, Mateusz Piętak, Szymon Staneta, Weronika Fortuniak, Barbara Kruczyk, Adam Kobiernik, Piotr Bakuła, Anna Mydlak, Tomasz Demkow, Bożena Sikora-Kupis, Paulina Dumnicka and Jakub Kucharz
Medicina 2024, 60(3), 398; https://doi.org/10.3390/medicina60030398 - 26 Feb 2024
Viewed by 1107
Abstract
Background and Objectives: More than 430,000 new cases of renal cell carcinoma (RCC) were reported in 2020. Clear cell RCC, which occurs in 80% of cases, is often associated with mutations in the VHL gene, leading to dysregulation of hypoxia-induced transcription factors pathways [...] Read more.
Background and Objectives: More than 430,000 new cases of renal cell carcinoma (RCC) were reported in 2020. Clear cell RCC, which occurs in 80% of cases, is often associated with mutations in the VHL gene, leading to dysregulation of hypoxia-induced transcription factors pathways and carcinogenesis. The purpose of this study is to examine the adverse events (AEs) of cabozantinib treatment and the relationship between individual patient factors and the frequency of their occurrence in detail. Materials and Methods: Seventy-one patients with metastatic RCC were treated with second or further lines of cabozantinib at the Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology. Comprehensive data, including demographics, clinicopathological factors, and AEs, were collected from January 2017 to June 2021. This study evaluated the impact of various patient-related factors on the rate of adverse events and treatment tolerance using a Cox proportional hazards model. Results: Cabozantinib-induced AEs were significantly associated with body mass index (BMI), body surface area (BSA), IMDC prognostic score, and treatment line. Notably, patients receiving cabozantinib post-tyrosine kinase inhibitors reported fewer AEs. Dose reduction was unrelated to adverse event frequency, but patients requiring dose reduction were characterized with lower body mass and BSA but not BMI. Conclusions: The factors described make it possible to predict the incidence of AEs, which allows for faster detection and easier management, especially in the high-risk group. AEs should be reported in detail in real-world studies, as their occurrence has a significant impact on prognosis. Full article
(This article belongs to the Special Issue Updates on Metastatic Renal Cell Carcinoma)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop