Glucose Homeostasis

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Endocrinology".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 2529

Special Issue Editor


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Guest Editor
Laboratory of Neuroendocrinology and Obesity, Department of Physiology and Pharmacology, Faculty of Medicine, Institute of Biomedical Research of Salamanca (IBSAL) and Institute of Neurosciences of Castilla y León (INCyL), University of Salamanca, Spain
Interests: diabetes mellitus; pharmacotherapy; glucose homeostasis; insulin resistance; adipose tissue and adipokines; obesity; neuroendocrinology

Special Issue Information

Dear Colleagues,

Keeping adequate glucose homeostasis involves several mechanisms concerning pancreatic islets, as well as the liver, adipose tissue, skeletal muscle, and nervous system. Several cells of such tissues release hormones and cytokines so that all of those elements are well coordinated to elicit the responses needed in physiological and pathological situations. It is noteworthy that disturbances in blood glucose levels are linked to noncommunicable chronic diseases like diabetes mellitus, which frequently converges with obesity, and both conditions are also recognized as cardiovascular risk factors that could lead to other morbidities. The prevention or treatment of such disorders could improve or restore glycemia, benefiting even associated pathologies (however, any intervention regarding lifestyle, dietary habits, physical exercise, pharmacological therapy, etc., should be carefully implemented).

This Special Issue of Medicina, entitled “Glucose Homeostasis”, is pleased to welcome the submission of manuscripts focused on the above-mentioned features, either reporting original experimental or clinical research, as well as up-to-date review articles. Other possible topics may include but are not limited to the following:

- Antihyperglycemic and/or antiobesity drugs assessment;

- Avoiding hypoglycemia and its consequences;

- Pharmacological treatment for diabetic complications;

- Affording cardiovascular diseases (CVD) and dysglycemia;

- Signaling pathways related to insulin secretion and its actions;

- Determinants of glucose disposal and transport in peripheral tissues;

- Cross-talk between adipose tissue and skeletal muscle in lipid and glucose metabolism: relevance of adipokines, batokines, and myokines;

- Regulation of intermediate metabolism by gut hormones, microbiota, and nutrients;

- New perspectives on cardiometabolic syndrome or prediabetes (impaired fasting glucose and/or impaired glucose tolerance);

- Coping stressful states (e.g., psychiatric or infectious diseases) and glucose control upsets.

Prof. Dr. Maria Carmen Iglesias-Osma
Guest Editor

Manuscript Submission Information

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Keywords

  • glucose homeostasis
  • diabetes mellitus
  • insulin release
  • glucose utilization and/or transport
  • obesity
  • insulin resistance
  • metabolic syndrome
  • dietary intervention
  • physical activity
  • drug therapy

Published Papers (1 paper)

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Review

7 pages, 286 KiB  
Review
An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes
by Małgorzata Mirr and Maciej Owecki
Medicina 2021, 57(2), 100; https://doi.org/10.3390/medicina57020100 - 23 Jan 2021
Cited by 6 | Viewed by 2156
Abstract
Insulin resistance refers to the diminished response of peripheral tissues to insulin and is considered the major risk factor for type 2 diabetes. Although many possible mechanisms have been reported to develop insulin resistance, the exact underlying processes remain unclear. In recent years, [...] Read more.
Insulin resistance refers to the diminished response of peripheral tissues to insulin and is considered the major risk factor for type 2 diabetes. Although many possible mechanisms have been reported to develop insulin resistance, the exact underlying processes remain unclear. In recent years, the role of adipose tissue as a highly active metabolic and endocrine organ, producing proteins called adipokines and their multidirectional activities has gained interest. The physiological effects of adipokines include energy homeostasis and insulin sensitivity regulation. In addition, an excess of adipose tissue is followed by proinflammatory state which results in dysregulation of secreted cytokines contributing to insulin resistance. Wingless-type (Wnt) inducible signalling pathway protein-1 (WISP-1), also known as CCN4, has recently been described as a novel adipokine, whose circulating levels are elevated in obese and insulin resistant individuals. Growing evidence suggests that WISP-1 may participate in the impaired glucose homeostasis. In this review, we characterize WISP-1 and summarize the latest reports on the role of WISP-1 in obesity, insulin resistance and type 2 diabetes. Full article
(This article belongs to the Special Issue Glucose Homeostasis)
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