Intestinal Permeability and Approach to Healing the Gut
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".
Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 3489
Special Issue Editor
Interests: Crohn’s disease; ulcerative colitis; colitis-associated colorectal cancer; barrier dysfunction
Special Issue Information
Dear Colleagues,
Gut health is of prime importance to maintaining a healthy daily routine, as an upset gut affects our overall functioning because of its connections with the brain. Despite the mass of studies on gastrointestinal (GI) disorders such as colitis, celiac disease and irritable bowel syndrome (IBS), the exact etiology of many disorders remains unknown. One of the factors known to be associated with various GI disorders is intestinal permeability. Alterations in tight junction (TJ) and adherent junction (AJ) proteins have been shown to destabilize cell contacts and facilitate the invasion of pathogens, leading to chronic inflammatory conditions. Furthermore, inflammatory cytokines destabilize junction molecules by internalization or proteolysis via activating the mediators of signaling pathways such as small GTPase. Apart from other various non-invasive strategies, one of the approaches to healing gastrointestinal conditions resulting from changes in gut permeability is by restoring the altered junction molecules.
The journal Medicina, under the section “Gastrointestinal Disorders”, is inviting gastroenterologists and basic science researchers who have been involved in studying various gastrointestinal disorders to share their novel findings on the status of junction proteins toward advancing our knowledge in understanding the pathogenesis of the various disorders. Furthermore, submission on the role of immune dysregulation, microbiota changes and signaling pathways identified in the initiation and perpetuation of the disorders will be appreciated.
Dr. Suhrid Banskota
Guest Editor
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Keywords
- inflammatory bowel disease
- irritable bowel syndrome
- celiac disease
- gut–brain axis
- altered gut microbiota
- inflammatory cytokines
- immune dysregulation
- altered GI secretions
- epigenetic changes in junction proteins
- barrier function in gut
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