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Medicina
Special Issues
Research Progress in Hepatitis B Virus
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Research Progress in Hepatitis B Virus

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 3118

Special Issue Editor

Dr. Satoru Joshita

E-Mail Website
Guest Editor
Shinshu University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, 3-1-1 Asahi, Matsumoto, Japan
Interests: laboratory medicine; non-invasive diagnostic methods; non-invasive liver fibrosis markers; viral hepatitis; hepatocellular carcinoma; autoimmune liver disease; metabolism in the liver; clinical immunology

Special Issue Information

Dear Colleagues, 

The clinical manifestations of hepatitis B virus (HBV) infection range from an asymptomatic carrier state to chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) in the chronic phase. As the course of the disease is determined by a complex interplay between viral replication and host immune responses, the clinical picture of chronic HBV infection remains uncertain. HCC is complicated by a global concern regarding chronic HBV infection. However, nucleos(t)ide analogs (NUCs) have revolutionized HBV therapy, indicating that we are on the way towards HBV elimination. Hepatitis B surface antigen (HBsAg) loss is the final clinical goal of chronic HBV treatment. Nonetheless, clinicians sometimes encounter patients who progress to HCC after HBsAg clearance, which raises questions about a link between HBsAg loss and HCC complications. Recent studies have identified several non-invasive diagnostic methods in HBV clinical medicine, including serological indices, non-invasive liver fibrosis markers, and HBV-related markers, such as hepatitis B core-related antigen (HBcrAg). These methods will aid in the timely detection and treatment of HBV.

The purpose of this Special Issue of Medicina, entitled “Hepatitis B Virus”, is to discuss the following:
1) The clinical interactions between HBsAg and complicating HCC
2) The associations between non-invasive clinical indices and the development of HCC

We welcome summaries on the current developments in clinical medicine on HBV, and preliminary studies, original research papers, systematic reviews, meta-analyses, and contributions on any newly developing discoveries and future directions focused on the field of HBV medicine.

Dr. Satoru Joshita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hepatitis B surface antigen
  • Hepatitis B core-related antigen
  • Hepatitis B core antigen
  • Hepatocellular carcinoma
  • Laboratory medicine
  • Nucleos(t)ide analogue

Published Papers (1 paper)

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10 pages, 3250 KiB  
Case Report
Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in a Patient with Chronic Hepatitis B Virus Infection: Case Report and Summary of the Literature
by Yuki Yamashita, Satoru Joshita, Hiroyuki Kobayashi, Shun-ichi Wakabayashi, Ayumi Sugiura, Tomoo Yamazaki and Takeji Umemura
Medicina 2021, 57(3), 280; https://doi.org/10.3390/medicina57030280 - 18 Mar 2021
Cited by 3 | Viewed by 2678
Abstract
Background: The incidence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is low, at 7–8% of all non-Hodgkin lymphoma cases. The most common site of MALT lymphoma occurrence is the stomach. Primary hepatic extranodal marginal zone lymphoma of MALT is [...] Read more.
Background: The incidence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is low, at 7–8% of all non-Hodgkin lymphoma cases. The most common site of MALT lymphoma occurrence is the stomach. Primary hepatic extranodal marginal zone lymphoma of MALT is classified as a type of non-gastric MALT lymphoma and is considered extremely rare, with no consensus on imaging study findings or treatment due to a limited number of reports. We herein describe a rare case of primary hepatic extranodal marginal zone lymphoma of MALT with underlying hepatitis B infection (HBV) and present useful diagnostic findings of various imaging modalities, including contrast-enhanced ultrasonography (CEUS) with Sonazoid. Case presentation: A 66-year-old woman was diagnosed as being a non-active carrier of HBV at 51 years of age at the time of total hysterectomy and bilateral adnexectomy for uterine cervical cancer. She was admitted to our hospital following the incidental detection of two focal liver lesions on computed tomography. The lesions were considered malignant based on clinical and other radiologic imaging findings. Her CEUS results of hypo-enhancement in the portal and late phases were consistent with those of previously reported cases of hepatic extranodal marginal zone lymphoma of MALT, and histological liver biopsy findings were compatible with the diagnosis. Conclusions: Primary hepatic extranodal marginal zone lymphoma of MALT is a rare condition that can appear in HBV carriers. Characteristic CEUS findings may help in disease diagnosis. Clinicians should bear primary hepatic extranodal marginal zone lymphoma of MALT in mind when encountering patients with focal liver lesions which exhibit image findings different from those of typical hepatocellular carcinoma. Full article
(This article belongs to the Special Issue Research Progress in Hepatitis B Virus)
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