Neuronutrition: Metabolomic Insights and Perspectives

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3414

Special Issue Editors


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Guest Editor
Biomedical Sciences Institute, Autonomous University of Ciudad Juarez, Ciudad Juarez, Chihuahua, Mexico
Interests: phenolic compounds; nutrients; nutrition physiology; public health; nutritional status; nutrition; anthropometry; physical activity; metabolic syndrome; cardiovascular; antioxidants; food chemistry; community nutrition
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Guest Editor
Research and Graduate Program in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Santiago de Querétaro 76010, Querétaro, Mexico
Interests: chrononutrition, clinical nutrition, metabolomics, food science, nutraceuticals, nutritional biochemistry, functional foods, gastrointes-tinal physiology

Special Issue Information

Dear Colleagues,

The central and peripheral nervous systems have a high demand for nutrients and xenobiotics with neurotrophic and neuromodulating activity, which often exceed the endogenous metabolic supply. Many organs in the body act in concert to satisfy such needs, using a quite sensitive communication network of intermediate metabolites, in which dietary bioactives converge as external signals and parent compounds. Functional Neuronutrition as a basic and applied science has advanced exponentially in the last decade, contributing to the prevention and control of numerous physiological deviations of the neurocognitive process. Moreover, the so-called “Neuronutritional approach” can influence a plethora of key neuro-epigenetic, immunological, and metabolic processes related to behavioral problems. The objective of this Special Issue on metabolites is to gather scientific articles that demonstrate new knowledge and advances in this field, welcoming systematic/narrative reviews, original articles, and future perspectives on the subject. Of special interest for this Special Issue are manuscripts that describe or outline the metabolic pathways involved in correct neuroendocrine functioning and those that describe abnormal metabolomic events (due to disease) and their correction by dietary bioactives.

Dr. Abraham Wall Medrano
Dr. Rocío Campos Vega
Guest Editors

Manuscript Submission Information

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Keywords

  • neuronutrition
  • neurological disorders
  • nutrition
  • functional foods
  • nutraceutical
  • nutrition physiology
  • nutriomics

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Published Papers (1 paper)

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Research

17 pages, 823 KiB  
Article
Maternal Dietary Deficiencies in Folic Acid and Choline Change Metabolites Levels in Offspring after Ischemic Stroke
by Faizan Anwar, Mary-Tyler Mosley, Paniz Jasbi, Jinhua Chi, Haiwei Gu and Nafisa M. Jadavji
Metabolites 2024, 14(10), 552; https://doi.org/10.3390/metabo14100552 - 16 Oct 2024
Viewed by 887
Abstract
Background/objectives: Ischemic stroke is a major health concern, and nutrition is a modifiable risk factor that can influence recovery outcomes. This study investigated the impact of maternal dietary deficiencies in folic acid (FADD) or choline (ChDD) on the metabolite profiles of offspring [...] Read more.
Background/objectives: Ischemic stroke is a major health concern, and nutrition is a modifiable risk factor that can influence recovery outcomes. This study investigated the impact of maternal dietary deficiencies in folic acid (FADD) or choline (ChDD) on the metabolite profiles of offspring after ischemic stroke. Methods: A total of 32 mice (17 males and 15 females) were used to analyze sex-specific differences in response to these deficiencies. Results: At 1-week post-stroke, female offspring from the FADD group showed the greatest number of altered metabolites, including pathways involved in cholesterol metabolism and neuroprotection. At 4 weeks post-stroke, both FADD and ChDD groups exhibited significant disruptions in metabolites linked to inflammation, oxidative stress, and neurotransmission. Conclusions: These alterations were more pronounced in females compared to males, suggesting sex-dependent responses to maternal dietary deficiencies. The practical implications of these findings suggest that ensuring adequate maternal nutrition during pregnancy may be crucial for reducing stroke susceptibility and improving post-stroke recovery in offspring. Nutritional supplementation strategies targeting folic acid and choline intake could potentially mitigate the long-term adverse effects on metabolic pathways and promote better neurological outcomes. Future research should explore these dietary interventions in clinical settings to develop comprehensive guidelines for maternal nutrition and stroke prevention. Full article
(This article belongs to the Special Issue Neuronutrition: Metabolomic Insights and Perspectives)
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