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Metabolites
Special Issues
Bioactive Compounds in Obesity and Its Metabolic Complications
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Bioactive Compounds in Obesity and Its Metabolic Complications

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1585

Special Issue Editors

Prof. Dr. Patricia Rios Chavez

E-Mail Website
Guest Editor
Facultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico
Interests: stress oxidative; obesity; natural products; antioxidant
Dr. Héctor Eduardo Martínez-Flores

E-Mail Website
Guest Editor
Facultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58240, Mexico
Interests: bioactive compounds; functional foods development and charac-terization; use of bioactive compounds in the prevention of chronic degenerative diseases

Special Issue Information

Dear Colleagues,

The problem of obesity has grown worldwide, along with related diseases such as hypertension, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), dyslipidemia and cardiovascular diseases. During obesity, adipocytes un-dergo hyperplasia and hypertrophy, and adipose tissues in other areas release adipokines and pro-inflammatory cytokines, leading to a low-grade inflammatory state that worsens these conditions. The production of oxidative stress is also linked to obesity and inflammation. 

This Special Issue is dedicated to research on natural compounds that provide a promising strategy to combat obesity and metabolic disease. The activity of these compounds can help reduce oxidative stress and attenuate the inflammatory process involved in obesity. It also includes topics such as the effects of metabolites on pharmacology and the underlying molecular mechanisms.  

Research in the fields of biochemistry, pharmacology, phytochemistry and medicine are invited to contribute to this Special Issue. 

Prof. Dr. Patricia Rios Chavez
Dr. Héctor Eduardo Martínez-Flores
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • obesity
  • inflammation
  • oxidative stress
  • metabolic syndrome

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Published Papers (2 papers)

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Research

18 pages, 1643 KB  
Article
Anti-Obesity Effects of a Standardized Prunus persica Flower Extract (HT099) Through the Regulation of Lipid Metabolism in High-Fat Diet-Induced Obese Mice
by Se-Young Kim, Minju Kim, Young-Woong Choi, Mi-Yeon Kim, Kun Yun, Young-Sik Kim and Hocheol Kim
Metabolites 2026, 16(2), 132; https://doi.org/10.3390/metabo16020132 - 13 Feb 2026
Viewed by 517
Abstract
Background: Obesity is one of the most prevalent metabolic disorders worldwide, and its long-term management remains challenging due to the limited efficacy and adverse effects of current pharmacological treatments. Accordingly, there is growing interest in safe and effective anti-obesity strategies based on [...] Read more.
Background: Obesity is one of the most prevalent metabolic disorders worldwide, and its long-term management remains challenging due to the limited efficacy and adverse effects of current pharmacological treatments. Accordingly, there is growing interest in safe and effective anti-obesity strategies based on natural compounds. This study aimed to evaluate the anti-obesity effects of HT099, an extract derived from Prunus persica (peach blossom), and to investigate molecular changes associated with its metabolic effects in a high-fat diet (HFD)-induced obesity mouse model. Methods: Male C57BL/6N mice were fed an HFD and orally administered HT099 (50 or 100 mg/kg) or the positive control orlistat (40 mg/kg) for 12 weeks. Body weight, adipose tissue accumulation, food efficiency ratio, glucose tolerance, serum lipid profiles, and hepatic gene expression related to lipid metabolism were evaluated. Results: HT099 supplementation significantly attenuated body weight gain and reduced white adipose tissue accumulation while improving food efficiency ratio. HT099 also ameliorated HFD-induced glucose intolerance and favorably modulated serum lipid profiles, including reduced triglyceride levels, increased HDL-cholesterol levels, and improved non-HDL cholesterol indices. At the molecular level, HT099 administration was associated with an increased hepatic AMPKα1 mRNA expression and decreased expression of adipogenic and lipogenic genes, including C/EBPα, PPARγ, FAS, and SREBP-1c. Conclusions: These findings indicate that HT099 exerts anti-obesity effects in HFD-induced obese mice, accompanied by improvements in lipid and glucose metabolism and changes in adipogenesis- and lipogenesis-related gene expression. Collectively, the results support the potential of HT099 as a natural bioactive agent for obesity management. Full article
(This article belongs to the Special Issue Bioactive Compounds in Obesity and Its Metabolic Complications)
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18 pages, 2323 KB  
Article
Evaluation of Callistemon citrinus Compounds to Reduce Brain Oxidative Stress in Rats Fed High-Fat-Sucrose Diet
by Aram Josué García-Calderón, Oliver Rafid Magaña-Rodríguez, Luis Alberto Ayala-Ruiz, José Armando Hernández-Soto, Jonathan Saúl Piñón-Simental, Luis Gerardo Ortega-Pérez, Asdrubal Aguilera-Méndez and Patricia Ríos-Chávez
Metabolites 2026, 16(1), 24; https://doi.org/10.3390/metabo16010024 - 25 Dec 2025
Viewed by 761
Abstract
Background: The association between oxidative stress and inflammation in obesity motivates investigation of the effects of d-limonene, gallic acid, ellagic acid, p-coumaric acid, and their mixture, which are major compounds of Callistemon citrinus, on oxidative stress and inflammation in the brains [...] Read more.
Background: The association between oxidative stress and inflammation in obesity motivates investigation of the effects of d-limonene, gallic acid, ellagic acid, p-coumaric acid, and their mixture, which are major compounds of Callistemon citrinus, on oxidative stress and inflammation in the brains of rats fed a high-fat-sucrose diet. This study aimed to identify the specific bioactive compounds in C. citrinus leaf extract responsible for its neuroprotective effects against diet-induced oxidative stress and neuroinflammation. Methods: Forty-eight male Wistar rats were randomly divided into eight groups (n = 6). Group 1 (control) received a standard diet, while group 2 received a high-fat, high-sucrose diet (HFSD). Groups 3, 4, 5, 6, 7, and 8 were also fed HFSD supplemented with C. citrinus extract, its main compounds, and a mixture of these compounds administered once daily via oral cannula for 23 weeks. The antioxidant and pro-inflammatory enzymes, along with oxidative biomarkers, were evaluated in the brains of the rats. Results:C. citrinus leaf extract and its four main components, both separately and together, modulated the activities of catalase, superoxide dismutase, glutathione peroxidase, and paraoxonase-1. They also affected levels of reduced glutathione while decreasing the amounts of advanced oxidative protein products, malondialdehyde, and 4-hydroxynonenal. Additionally, they decreased the activities of cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, xanthine oxidase, and myeloperoxidase in the brains of rats, despite a high-fat-sucrose diet. Conclusions: These results show that the main compounds in C. citrinus leaf extract are essential for its antioxidant and anti-inflammatory effects, which help protect against oxidative stress in the brains of rats on a high-calorie diet. Full article
(This article belongs to the Special Issue Bioactive Compounds in Obesity and Its Metabolic Complications)
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