Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 736

Special Issue Editor


E-Mail Website
Guest Editor
UMR 7200 Laboratoire d’Innovation Thérapeutique, CNRS, Strasbourg Drug Discovery and Development Institute (IMS), Université de Strasbourg, 67400 Illkirch-Graffenstaden, France
Interests: ethnopharmacology; dereplication; natural products; pharmacomodulation

Special Issue Information

Dear Colleagues,

Plants play a crucial role in preventing and treating a vast array of illnesses, particularly in regions where modern healthcare access is deficient. The knowledge of traditional healers of local medicinal plants and their preparations/administrations is a rich source of potential bioactive compounds that could be a base for the development of new therapeutic options. However, most of these traditional remedies remain largely unexplored in terms of their scientific validation, chemical constitution, biological activity, and safety administration. The rapid identification, isolation, and biological evaluation of bioactive plant metabolites are the first steps in unveiling the potential for drug development. This Special Issue welcomes the submission of studies concerning phytochemical characterization by the dereplication (LC-MS/MS, NMR), isolation, and biological evaluation of plant metabolites from bioactive extracts. 

Dr. Sergio Ortiz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extraction
  • metabolomics
  • phytochemical dereplication
  • isolation of plant metabolites
  • biological evaluation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

15 pages, 1254 KB  
Review
Ethnomedicinal Applications, Phytochemistry, and Pharmacological Properties of Zanthoxylum caribaeum Lam.: A Comprehensive Review
by Ahissan Innocent Adou, Ebed Fleurima, Valendy Thesnor, Ander Urrutia, Alain Fournet, Marie-Noëlle Sylvestre, Muriel Sylvestre, Zohra Benfodda and Gerardo Cebrián-Torrejón
Metabolites 2025, 15(9), 614; https://doi.org/10.3390/metabo15090614 - 16 Sep 2025
Viewed by 355
Abstract
Zanthoxylum caribaeum Lam. is a member of the Rutaceae Family that can be naturally found in South and central America (Brazil, Paraguay, Bolivia, Caribbean, etc.). Its traditional medicinal uses are well documented among native communities, such as that of the Guarani, in Paraguay. [...] Read more.
Zanthoxylum caribaeum Lam. is a member of the Rutaceae Family that can be naturally found in South and central America (Brazil, Paraguay, Bolivia, Caribbean, etc.). Its traditional medicinal uses are well documented among native communities, such as that of the Guarani, in Paraguay. More than 60 metabolites, including alkaloids, terpenoids, coumarins, and alkylamides, have been identified in its leaves, bark, and fruits. The biological activities and mechanisms of action of several of these compounds, as well as those of crude extracts, have also been investigated by previous studies. As a medicinal and edible plant, Z. caribaeum shows promising applications in the pharmacological industry. For the last 25 years, a significant amount of research has been conducted with Z. caribaeum to better understand its toxicity and complex mechanisms of action, bringing science-based clinical safety to its traditional uses. This review integrates available knowledge chemical and biological data on this species. It emphasizes the diversity of bioactive metabolites, their associated bioactivities, and provides an updated overview of the plant’s advances in ethnopharmacology, phytochemistry, pharmacology, agricultural exploitation, and potential utilization. Full article
Show Figures

Figure 1

Back to TopTop