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Metabolites
Special Issues
Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders
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Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 1771

Special Issue Editors

Dr. Sylwia Dzięgielewska-Gęsiak

E-Mail Website
Guest Editor
Department of Propaedeutics of Internal Diseases and Emergency Medicine, Medical University of Silesia in Katowice, 41-902 Bytom, Poland
Interests: metabolic syndrome; oxidative stress; nutritional pro-oxidants and anti-oxidants; next generating sequence; autopgahy
Special Issues, Collections and Topics in MDPI journals
Dr. Teresa Grzelak

E-Mail Website
Guest Editor
Department of Physiology, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland
Interests: obesity; hypertension; glucose tolerance; insulin resistance; metabolic syndrome; circadian clock; biological clocks; total antioxidant status; inflammation markers; cytokines; bioavailability of diet compounds; diet; nutritional status; nutritional attitudes; nutritional behaviors
Dr. Grzegorz Dziubanek

E-Mail Website
Guest Editor
Department of Environmental Health, Medical University of Silesia in Katowice, 41-902 Bytom, Poland
Interests: bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota, dietary supplements; trace elements; heavy metals

Special Issue Information

Dear Colleagues,

As we age, the body changes. Nutritional behaviors and attitudes evolve with aging, which may lead to age-related diseases. The question is why some people live longer without health problems and some develop diseases earlier during adulthood. It is known that healthy aging proceeds with changes in genome, but this is also modified by autocrine, paracrine, and endocrine activities in the body as well as the environment, which leads to increased oxidative stress and accelerated inflammation. So far, different metabolic pathways may lead to better and worse aging processes. Obesity, hypertension, and insulin resistance are seen while we age. What is more, they are characterized by a low-grade chronic inflammatory state and accelerated prooxidant status. Thus, we encourage research spanning from basic science to different clinical disciplines to participate in this Special Issue to serve as a platform to discuss metabolic pathways and metabolites which can have an influence on successful aging. We would also like to discuss age-related metabolic disorders and their metabolic pathways due to environmental/nutritional status, which are caused by inflammation and/or oxidative stress.

Dr. Sylwia Dzięgielewska-Gęsiak
Dr. Teresa Grzelak
Dr. Grzegorz Dziubanek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional attitudes and behaviors
  • bioconcentration factor
  • health risk assessment
  • dietary exposure
  • farm-fresh foods
  • medicinal plants
  • gut microbiota
  • dietary supplements
  • trace elements—Zn, Cu
  • heavy metals

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Published Papers (2 papers)

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14 pages, 447 KiB  
Article
Relationship of SOD-1 Activity in Metabolic Syndrome and/or Frailty in Elderly Individuals
by Sylwia Dzięgielewska-Gęsiak, Ewa Wysocka, Edyta Fatyga and Małgorzata Muc-Wierzgoń
Metabolites 2024, 14(9), 514; https://doi.org/10.3390/metabo14090514 - 23 Sep 2024
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Abstract
Introduction: Although aging is a natural phenomenon, in recent years it has accelerated. One key factor implicated in the aging process is oxidative stress. Oxidative stress also plays a role in frailty (frail) and metabolic syndrome (MetS). Methods: A total of 66 elderly [...] Read more.
Introduction: Although aging is a natural phenomenon, in recent years it has accelerated. One key factor implicated in the aging process is oxidative stress. Oxidative stress also plays a role in frailty (frail) and metabolic syndrome (MetS). Methods: A total of 66 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed for waist circumference (WC), arterial blood pressure, glycemia, glycated hemoglobin (HbA1c), plasma lipids, and activity of erythrocyte superoxide dismutase (SOD-1). Patients were classified as NonMetS-Nonfrail (n = 19), NonMetS-frail (n = 20), MetS-Nonfrail (n = 17), or MetS-frail (n = 10). Results: There were no significant differences in superoxide dismutase activity among investigated elderly groups. However, the data suggest that MetS individuals, both frail and nonfrail, have higher risk factors for cardiovascular disease compared to NonMetS individuals. The correlations analyses of SOD-1 and other metabolic indices suggest that SOD-1 levels may be influenced by age, total cholesterol, HDL cholesterol, and fasting glucose levels in certain groups of seniors. Conclusions: Aging is associated with decreased antioxidant enzyme SOD-1 activity with glucose alteration in frailty syndrome as well as with lipids disturbances in metabolic syndrome. These factors provide a nuanced view of how frailty and metabolic syndrome interact with various health parameters, informing both clinical practice and future research directions. Full article
(This article belongs to the Special Issue Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders)
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19 pages, 2507 KiB  
Article
Selenium, Zinc, and Plasma Total Antioxidant Status and the Risk of Colorectal Adenoma and Cancer
by Miłosława Zowczak-Drabarczyk, Jacek Białecki, Teresa Grzelak, Mikołaj Michalik and Dorota Formanowicz
Metabolites 2024, 14(9), 486; https://doi.org/10.3390/metabo14090486 - 6 Sep 2024
Viewed by 536
Abstract
Selenium (Se), zinc (Zn), and copper (Cu) are known to be involved in carcinogenesis and participate in the defence against reactive oxygen species (ROS). This study aimed to evaluate the clinical utility of serum Se, Zn, and Cu concentrations and plasma total antioxidant [...] Read more.
Selenium (Se), zinc (Zn), and copper (Cu) are known to be involved in carcinogenesis and participate in the defence against reactive oxygen species (ROS). This study aimed to evaluate the clinical utility of serum Se, Zn, and Cu concentrations and plasma total antioxidant status (TAS) in the diagnosis of colorectal cancer (CRC) and colorectal adenoma (CRA) in a population of low Se and borderline Zn status. Based on clinical examination and colonoscopy/histopathology, the patients (n = 79) were divided into three groups: colorectal cancer (n = 30), colorectal adenoma (n = 19), and controls (CONTROL, n = 30). The serum Se concentration was lower in the CRC group than in the CRA group (by 9.1%, p < 0.0001) and the CONTROL group (by 7.9%, p < 0.0001). In turn, the serum Zn concentration was decreased in the CRA group (by 17.9%, p = 0.019) when compared to the CONTROL group. Plasma TAS was lower in the CRC group (by 27.8%, p = 0.017) than in the CONTROL group. In turn, the serum Zn concentration was decreased in the CRA group when compared to the CONTROL group. Plasma TAS was lower in the CRC group than in the CONTROL group. ROC (receiver operating characteristic) curve analysis revealed that the Se level was of the highest diagnostic utility for the discrimination of the CRC group from both the CRA group (area under ROC curve (AUC) 0.958, sensitivity 84.21%, specificity 100%) and the CONTROL group (AUC 0.873, sensitivity 100%, specificity 66.67%). The Zn and TAS levels were significantly accurate in the differentiation between the groups. An individualised risk of colorectal adenoma and cancer approach could comprise Se, Zn, and TAS assays in the population. Full article
(This article belongs to the Special Issue Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders)
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