Discovering Novel Biomarkers of Parkinson Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2218
Special Issue Editors
Interests: neurodegeneration; movement disorders; iron metabolism; Parkinson´s disease; biomarkers; magnetic resonance imaging; positron emission imaging
Interests: neurodegeneration; movement disorders; Parkinson´s disease; biomarkers; magnetic resonance imaging; positron emission imaging; PET methodology; functional MRI
Special Issue Information
Dear Colleagues,
Parkinson´s disease (PD) is the second most common neurodegenerative disorder, with a globally estimated prevalence of more than 8.5 million individuals. Unfortunately, disability due to PD is increasing faster than any other neurological disorders. The clinical diagnosis of PD is difficult in the early stages of the disease, with high risk of misdiagnosis (about 35% of cases) associated with difficulties in predicting the disease progression. There is a strong need for biomarkers for the correct diagnosis and monitoring of PD.
In recent decades, there has been an increase in knowledge regarding the pathophysiological mechanism underlying PD due to the development of neuroimaging and bio-fluid biomarkers, as well as advancements in the omics fields (metabolomics, proteomics, genomics and transcriptomics). Furthermore, digital biometry techniques are helping in the diagnosis and the monitoring of treatment in PD. The identification of robust biomarkers would help in the optimization of new therapeutic strategies that will also help in the early diagnosis and monitoring of the disease.
This Special Issue aims to include research studies and reviews, including clinical and preclinical studies focused on novels biomarkers in PD. We also aim to include review studies and meta-analyses that investigate the diagnostic or prognostic value of the identified potential PD biomarkers. Methodological articles that present novel neuroimaging biomarkers and validation will be particularly considered.
Dr. Antonio Martin-Bastida
Dr. Nick P. Lao-Kaim
Guest Editors
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Keywords
- biomarkers
- magnetic resonance imaging
- molecular imaging
- omics
- bio-fluid biomarkers
- cerebrospinal fluid
- digital biometry
- Parkinson’s disease
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