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Metabolites
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Metabolic Effects of Foregut Surgery in the Management of Obesity...
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Metabolic Effects of Foregut Surgery in the Management of Obesity and Diabetes

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 382

Special Issue Editors

Prof. Dr. Sungsoo Park

E-Mail Website
Guest Editor
Division of Foregut Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea
Interests: bariatric surgery; onco-metabolic surgery; gastric cancer
Dr. Yeongkeun Kwon

E-Mail Website
Guest Editor
Division of Foregut Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea
Interests: obesity; bariatric surgery; type 2 diabetes; onco-metabolic surgery

Special Issue Information

Dear Colleagues,

Metabolomic research has highlighted that foregut surgery (bariatric surgery or gastric cancer surgery) is responsible for metabolic effects and immediately alters various metabolic pathways. Investigations for discovering biomarkers predicting the outcome of foregut surgery are in the preliminary stages. Extensive research should be performed to identify significant metabolites and as well as to develop models and validate their predictive performance prior to clinical application. Preoperative prediction of metabolic effects induced by foregut surgery will enable better selection of surgical candidates and improve pre- and postoperative management of patients. Understanding short- and long-term systemic adaptations to foregut surgery may provide insights into the mechanisms underlying weight loss and comorbidities improvement and can lead to the discovery of new drug targets for obesity or diabetes treatment.

Prof. Dr. Sungsoo Park
Dr. Yeongkeun Kwon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bariatric surgery
  • metabolic surgery
  • gastric cancer surgery
  • metabolomics
  • biomarker
  • obesity
  • type 2 diabetes

Published Papers (1 paper)

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Research

10 pages, 933 KiB  
Article
Association Between Indole-3-Pyruvic Acid and Change in Fat-Free Mass Relative to Weight Loss in Patients Undergoing Sleeve Gastrectomy
by Eunhye Seo, Yeongkeun Kwon and Sungsoo Park
Metabolites 2024, 14(8), 444; https://doi.org/10.3390/metabo14080444 (registering DOI) - 11 Aug 2024
Viewed by 17
Abstract
Sleeve gastrectomy typically leads to weight loss, including a reduction in fat-free mass (FFM). Studies have shown significant FFM loss within 1 year after the procedure but with individual variations. This study aimed to assess whether preoperative amino acid metabolite levels can predict [...] Read more.
Sleeve gastrectomy typically leads to weight loss, including a reduction in fat-free mass (FFM). Studies have shown significant FFM loss within 1 year after the procedure but with individual variations. This study aimed to assess whether preoperative amino acid metabolite levels can predict FFM changes following sleeve gastrectomy. This study involved 42 patients. Body weight, fat mass (FM), and FFM were measured preoperatively and 3, 6, and 12 months postoperatively. All participants experienced weight loss, FM reduction, and FFM decrease for up to 3 months after surgery. However, the following distinct groups emerged from 3 to 6 months postoperatively: one showed FFM gain relative to weight loss, whereas the other exhibited continued FFM reduction relative to weight loss. This trend persisted for up to 12 months postoperatively and became more pronounced. The group with FFM gain had lower preoperative BMI and higher levels of indole-3-pyruvic acid (IPyA). Logistic regression and ROC curve analyses confirmed IPyA’s ability to predict FFM gain between 3 and 6 months after sleeve gastrectomy, with a useful cutoff value of 20.205. Preoperative IPyA levels were associated with FFM gain relative to weight loss in the 3 to 6 months following sleeve gastrectomy. These findings suggest that IPyA may be a potential predictor for FFM changes during this period. Full article
(This article belongs to the Special Issue Metabolic Effects of Foregut Surgery in the Management of Obesity and Diabetes)
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