Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 97
Special Issue Editors
Interests: metabolomics; bioinformatics; microbial metabolism
Interests: mass spectrometry informatics; metabolomics
Special Issue Information
Dear Colleagues,
The human gastrointestinal tract harbors trillions of microbes that influence human health and physiology. Dysbiosis of the gut microbiome may contribute to the pathogenesis of various diseases, including obesity, type 2 diabetes (T2D), cardiovascular disease (CVD), inflammatory bowel disease (IBD), metabolic-associated fatty liver disease, and so on. One of the key ways that the gut microbiota affects the host’s health is by producing bioactive metabolites, namely gut microbiota-derived metabolites. These metabolites can be further absorbed and enter the host circulation system, where they then affect human health. Liquid chromatography–mass spectrometry-based metabolomics, together with advances in bioinformatics, enables the capture of thousands of metabolites, facilitating the identification of potential mechanistic links between the gut microbiome, the metabolome, and host phenotypes.
This Special Issue aims to facilitate the development and applications of metabolomics and bioinformatics approaches in gut microbiome research to elucidate the impact of gut microbiota-derived metabolites on human health and diseases. It welcomes original research articles, short communications, protocols, reviews, and perspectives on topics including, but not limited to, the following: 1) the development of analytical methodologies to qualify and quantify gut microbiota-derived metabolites; 2) advanced metabolomics and bioinformatics approaches (algorithms, tools, databases) to accelerate data analysis of the microbiome and metabolomics; 3) metabolomics and multiomics studies of bacterial cultures, animal models, and human cohort samples to deepen our understanding of the impact of the gut microbiome; 4) the roles and impacts of the gut microbiome and its derived metabolites on host health and diseases.
Dr. Zhiwei Zhou
Dr. Shipei Xing
Dr. Xiaotao Shen
Guest Editors
Manuscript Submission Information
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Keywords
- metabolomics
- bioinformatics
- databases
- gut microbiota
- microbiome
- host–microbe interaction
- microbial metabolism
- multiomics
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