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Metabolites
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Environmental Metabolites Insights into Health and Disease
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Environmental Metabolites Insights into Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1464

Special Issue Editor

Prof. Dr. Yu Sun

E-Mail Website
Guest Editor
College of Life Sciences, South China Agricultural University, Guangzhou, China
Interests: Indoor microbiome and metabolome; human gut microbiome; asthma and rhinitis; mycotoxin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the complex interactions between environmental metabolites and their impacts on both human and animal health. Environmental metabolites encompass a wide range of chemical compounds resulting from environmental exposures, including both harmful toxins and beneficial protectants. Understanding these metabolites is crucial for elucidating the mechanisms through which environmental factors influence health outcomes in humans and animals.

The scope of this Special Issue is broad, encompassing studies on the identification, characterization, and functional roles of environmental metabolites. We invite contributions that investigate the following:

  • The metabolic pathways influenced by environmental exposures.
  • The role of environmental metabolites in the onset and progression of diseases in humans.
  • Protective metabolites and their potential in mitigating environmental health risks.
  • The impact of environmental metabolites on the health and productivity of breeding animals such as pigs, cows, and chickens.
  • Molecular mechanistic research that elucidates the underlying biological processes affected by environmental metabolites.
  • Technological advancements in metabolomics that enhance the detection and analysis of environmental metabolites.
  • Integrative approaches combining metabolomics with genomics, proteomics, and other omics technologies to provide a comprehensive understanding of environmental health impacts.

The purpose of this Special Issue is to provide a platform for researchers to present their latest findings on the dual role of environmental metabolites in health and disease for both humans and animals. By highlighting cutting-edge research and innovative methodologies, we aim to foster a deeper understanding of how environmental exposures translate into metabolic changes and subsequent health outcomes. This Special Issue seeks to attract a diverse group of scientists from various disciplines, including toxicology, epidemiology, molecular biology, veterinary science, and public health, to contribute to a comprehensive dialogue on environmental health. Ultimately, our goal is to inform public health and veterinary strategies and interventions that can mitigate adverse health effects while leveraging protective metabolites for improved health and productivity outcomes.

We encourage submissions that offer novel insights and advance the field of environmental metabolomics, paving the way for future research and applications in health and disease prevention in both humans and animals. Molecular mechanistic research within this topic is particularly welcome, as it can provide detailed insights into the biological processes affected by environmental metabolites.

Prof. Dr. Yu Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental metabolites
  • probiotics
  • health
  • disease
  • toxic metabolites
  • protective metabolites
  • metabolomics
  • environmental exposure
  • molecular mechanisms
  • metabolic pathways

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Published Papers (2 papers)

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Research

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22 pages, 1629 KiB  
Article
MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis
by Zheyuan Ou, Xi Fu, Dan Norbäck, Ruqin Lin, Jikai Wen and Yu Sun
Metabolites 2025, 15(1), 51; https://doi.org/10.3390/metabo15010051 - 14 Jan 2025
Abstract
Background/Objectives: The integration of microbiome and metabolome data could unveil profound insights into biological processes. However, widely used multi-omic data analyses often employ a stepwise mining approach, failing to harness the full potential of multi-omic datasets and leading to reduced detection accuracy. Synergistic [...] Read more.
Background/Objectives: The integration of microbiome and metabolome data could unveil profound insights into biological processes. However, widely used multi-omic data analyses often employ a stepwise mining approach, failing to harness the full potential of multi-omic datasets and leading to reduced detection accuracy. Synergistic analysis incorporating microbiome/metabolome data are essential for deeper understanding. Method: This study introduces a Coupled Matrix and Tensor Factorization (CMTF) framework for the joint analysis of microbiome and metabolome data, overcoming these limitations. Two CMTF frameworks were developed to factorize microbial taxa, functional pathways, and metabolites into latent factors, facilitating dimension reduction and biomarker identification. Validation was conducted using three diverse microbiome/metabolome datasets, including built environments and human gut samples from inflammatory bowel disease (IBD) and COVID-19 studies. Results: Our results revealed biologically meaningful biomarkers, such as Bacteroides vulgatus and acylcarnitines associated with IBD and pyroglutamic acid and p-cresol associated with COVID-19 outcomes, which provide new avenues for research. The CMTF framework consistently outperformed traditional methods in both dimension reduction and biomarker detection, offering a robust tool for uncovering biologically relevant insights. Conclusions: Despite its stringent data requirements, including the reliance on stratified microbial-based pathway abundances and taxa-level contributions, this approach provides a significant step forward in multi-omics integration and analysis, with potential applications across biomedical, environmental, and agricultural research. Full article
(This article belongs to the Special Issue Environmental Metabolites Insights into Health and Disease)

Review

Jump to: Research

22 pages, 984 KiB  
Review
Molecular Mechanism of Indoor Exposure to Airborne Halogenated Flame Retardants TCIPP (Tris(1,3-Dichloro-2-Propyl) Phosphate) and TCEP Tris(2-chloroethyl) Phosphate and Their Hazardous Effects on Biological Systems
by Albatul Alharbi and Muhanad Alhujaily
Metabolites 2024, 14(12), 697; https://doi.org/10.3390/metabo14120697 - 10 Dec 2024
Viewed by 867
Abstract
TCIPP (tris(1,3-dichloro-2-propyl) phosphate) and TCEP (tris(2-chloroethyl) phosphate) are organophosphate ester flame retardants found in various consumer products, posing significant health and environmental risks through inhalation, ingestion, and dermal exposure. Research reveals these compounds cause oxidative stress, inflammation, endocrine disruption, genotoxicity, neurotoxicity, and potentially [...] Read more.
TCIPP (tris(1,3-dichloro-2-propyl) phosphate) and TCEP (tris(2-chloroethyl) phosphate) are organophosphate ester flame retardants found in various consumer products, posing significant health and environmental risks through inhalation, ingestion, and dermal exposure. Research reveals these compounds cause oxidative stress, inflammation, endocrine disruption, genotoxicity, neurotoxicity, and potentially hepatotoxicity, nephrotoxicity, cardiotoxicity, developmental, reproductive, and immunotoxicity. This review summarizes the current knowledge on the toxicological mechanisms of TCIPP and TCEP and presents the latest data on their toxicological effects obtained in vitro and in vivo, using omic systems, and on the basis of computational modelling. It also elaborates on the scope of further toxicities and highlights the necessity of ongoing mechanistic research, integration of new technologies, and successful transfer of the acquired knowledge into risk evaluation, policies and regulations, and the creation of safer products. Since flame retardants are already present in homes, schools, offices, and daycare centres, efforts to scale back the exposure to these chemicals, most especially the hazardous ones, must be made to protect human health and the environment. Therefore, effective and timely prevention, based upon a deep knowledge of the entire toxicological profile of these substances, is the only way to face this difficult toxicological issue and provide for a healthy and safe future. Full article
(This article belongs to the Special Issue Environmental Metabolites Insights into Health and Disease)
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