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Metabolites
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Metabolomics Meets Lifestyle Medicine
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Metabolomics Meets Lifestyle Medicine

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (16 August 2023) | Viewed by 5605

Special Issue Editor

Prof. Dr. Caroline Rhéaume

E-Mail Website
Guest Editor
Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada
Interests: metabolic syndrome; lifestyle medicine; physical activity; nutrition; primary care
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Physical activity, nutrition, and sleep are the most important lifestyle determinants of health. Physical inactivity and unhealthy nutrition are strong risk factors for disease and associated with a deteriorated cardiometabolic profile, but the mechanisms involved are elusive. Metabolic and physiologic responses to healthy eating habits and physical exercise have become an increasingly interesting area of research, but there is a need to introduce innovative clinical interventions. Metabolomic research is an ideal place to explore these concepts, as balanced nutrition and regular physical activity are generally recommended for their antioxidant capacity and for the prevention and treatment of several disorders, such as type II diabetes, dyslipidemia, obesity, and hypertension, which can lead to cardiovascular disease. Metabolomic research has made it possible to evaluate individual metabolic signatures in an innovative and exhaustive way by analyzing the composition of the metabolome in serum, urine, stool, and tissue samples. Despite advances made in knowledge in this research area, original strategies to measure metabolomics variables in human to capture genetic information, lifestyle habits, and clinical outcomes are still needed. Additionally, many challenges need to be addressed, including cardiometabolic variables that could be a better target to help physicians and health professionals track patients’ lifestyles and how to translate these findings into the daily practices of the medical community. This Special Issue is dedicated to better understanding metabolic syndrome and its associations with lifestyle habits such as nutrition and physical activity. Moreover, it would be interesting to further document some complex clinical cases such as metabolically healthy obese and adverse responders to a healthy lifestyle. Topics to be covered include (not exclusively) metabolomic studies of nutrition and physical activity and systemic and clinical studies related to structured lifestyle interventions to better manage metabolic syndrome. Therefore, in this Special Issue, metabolomics meets lifestyle medicine from various perspectives.

Prof. Dr. Caroline Rhéaume
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • lifestyle
  • nutrition
  • physical activity
  • biomarkers
  • metabolic signature
  • metabolomic
  • hypertension
  • obesity
  • diabetes

Published Papers (2 papers)

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Research

7 pages, 456 KiB  
Article
Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans
by Miriam Hoene, Xinjie Zhao, Jürgen Machann, Andreas L. Birkenfeld, Martin Heni, Andreas Peter, Andreas Niess, Anja Moller, Rainer Lehmann, Guowang Xu and Cora Weigert
Metabolites 2023, 13(1), 15; https://doi.org/10.3390/metabo13010015 - 22 Dec 2022
Cited by 6 | Viewed by 2658
Abstract
Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could [...] Read more.
Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced increase in Lac-Phe, both before and after the intervention. Higher levels of Lac-Phe after acute exercise were associated with a greater reduction in abdominal subcutaneous and, to a lower degree, visceral adipose tissue during the intervention. Lac-Phe produced during physical activity could contribute to weight loss by acting as a signaling molecule that regulates food intake, as previously shown in mice. Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity. Full article
(This article belongs to the Special Issue Metabolomics Meets Lifestyle Medicine)
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13 pages, 2461 KiB  
Article
Relationship between Cardiometabolic Factors and the Response of Blood Pressure to a One-Year Primary Care Lifestyle Intervention in Metabolic Syndrome Patients
by Elisa Marin-Couture, Marie-Josée Filion, Ryma Boukari, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Paula Brauer, Dawna Royall, David M. Mutch, Doug Klein, Angelo Tremblay and Caroline Rhéaume
Metabolites 2022, 12(9), 861; https://doi.org/10.3390/metabo12090861 - 14 Sep 2022
Cited by 3 | Viewed by 2110
Abstract
Systemic hypertension has been recognized as a modifiable traditional cardiovascular risk factor and influenced by many factors such as eating habits, physical activity, diabetes, and obesity. The objective of this cross-sectional study was to identify factors that predict changes in blood pressure induced [...] Read more.
Systemic hypertension has been recognized as a modifiable traditional cardiovascular risk factor and influenced by many factors such as eating habits, physical activity, diabetes, and obesity. The objective of this cross-sectional study was to identify factors that predict changes in blood pressure induced by a one-year lifestyle intervention in primary care settings involving a collaboration between family physicians, dietitians, and exercise specialists. Patients with metabolic syndrome diagnosis were recruited by family physicians participating in primary care lifestyle intervention among several family care clinics across Canada. Participants for whom all cardiometabolic data at the beginning (T0) and the end (T12) of the one-year intervention were available were included in the present analysis (n = 101). Patients visited the dietitian and the exercise specialist weekly for the first three months and monthly for the last nine months. Diet quality, exercise capacity, anthropometric indicators, and cardiometabolic variables were evaluated at T0 and at T12. The intervention induced a statistically significant decrease in waist circumference (WC), systolic (SBP) and diastolic (DBP) blood pressure, and plasma triglycerides, and an increase in cardiorespiratory fitness (estimated VO2max). Body weight (p < 0.001), body mass index (BMI) (p < 0.001), and fasting blood glucose (p = 0.006) reduction, and VO2max increase (p = 0.048) were all related to changes in SBP. WC was the only variable for which changes were significantly correlated with those in both SBP (p < 0.0001) and DBP (p = 0.0004). Variations in DBP were not associated with changes in other cardiometabolic variables to a statistically significant extent. Twelve participants were identified as adverse responders (AR) in both SBP and DBP and displayed less favorable changes in WC. The beneficial effects of the primary care lifestyle intervention on blood pressure were significantly associated with cardiometabolic variables, especially WC. These findings suggest that a structured lifestyle intervention in primary care can help improve cardiometabolic risk factors in patients with metabolic syndrome and that WC should be systematically measured to better stratify the patient’s hypertension risk. Full article
(This article belongs to the Special Issue Metabolomics Meets Lifestyle Medicine)
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