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Metabolites
Special Issues
Animal Nutritional Metabolism and Toxicosis Disease
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Animal Nutritional Metabolism and Toxicosis Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2651

Special Issue Editor

Dr. Meng-yao Guo

E-Mail Website
Guest Editor
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
Interests: high-fat food; mammals; fish; metabolic blocks; toxosis; treatment of disease

Special Issue Information

Dear Colleagues,

The field of study of this Special Issue includes animals and fish. The main research content focuses on nutritional metabolic disorders, including dysregulation of autoregulation and foodborne overintake or underintake. Nutrients can be proteins, lipids, sugars, or trace elements, and there are new processes to regulate or supplement nutrients. At the same time, the focus of this publication is animal toxicosis-related research content, especially new environmental toxicants, with the aim of exploring the relevant pathogenic mechanism and harm to animals. At the same time, related animal nutritional metabolic diseases and toxicosis treatment measures or drugs are also in the scope of this Special Issue. We welcome research dedicated to dealing with the digestion, absorption, transport, and metabolism of carbohydrates, amino acids, lipids, vitamins, minerals, organic acids, alkaloids, and drugs, as well as metabolomics, lipidomics, and the crosstalk between gastrointestinal microbiota and the host involved in nutritional and metabolic diseases in animals. This Special Issue is not only intended for results of studies about nutritional and metabolic diseases in domestic animals and in vitro models but is also open to results of studies from cell and animal models for human nutritional and metabolic diseases.

Dr. Meng-yao Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • high-fat food
  • mammals
  • fish
  • metabolic blocks
  • toxosis
  • treatment of disease

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Published Papers (3 papers)

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Research

16 pages, 3187 KiB  
Article
Non-Targeted Metabolomics of White Rhinoceros Colostrum and Its Changes During Early Lactation by 1H Nuclear Magnetic Resonance Spectroscopy
by Gernot Osthoff and Petronella Nieuwoudt
Metabolites 2024, 14(11), 637; https://doi.org/10.3390/metabo14110637 - 18 Nov 2024
Viewed by 369
Abstract
Background/Objectives: Dynamic changes in components from colostrum to mature milk occur in any mammal. However, the time it takes to reach the mature milk stage differs between taxa and species, as do the final concentrations of all the components. The white rhinoceros belongs [...] Read more.
Background/Objectives: Dynamic changes in components from colostrum to mature milk occur in any mammal. However, the time it takes to reach the mature milk stage differs between taxa and species, as do the final concentrations of all the components. The white rhinoceros belongs to the family Perissodactyla, of which the milk and milk metabolome of the domesticated Equidae have been studied to some detail. Metabolomic information on the colostrum and milk of the Rhinocerotidae is lacking. Methods: Colostrum and milk were obtained from seven white rhinoceroses. Of note is that it was their first parturition and all followed the same diet, two factors known to affect colostrum composition and its changes during early lactation in domesticated mammals. Milk serum was prepared by the ultrafiltration of the milk samples. Untargeted 1N NMR spectra were processed with Topspin 3.2, calibration was carried out according to the alanine signal and the identification of signals was carried out with Chenomx and assignments in the literature. Statistical analysis of the data was carried out using MetaboAnalyst 6.0. Results: The changes in the metabolites were followed during the first 7 days of lactation as well as on day 20. The amounts of amino acids and their derivatives, organic acids and lipid metabolites decreased over lactation, while carbohydrates and their derivatives increased. The colostrum phase ended on day 2, while the transition to mature milk seemed to be complete by day 7. From day 3 to 7, galactose metabolism and tyrosine metabolism were uprated. Of interest is the presence of the oligosaccharide 3′-sialyllactose on days 3 and 4 of lactation. Conclusions: Mainly the content of carbohydrates increased over lactation, specifically lactose. The 3′-sialyllactose content peaked on days 3 and 4 of lactation. The colostrum phase ended on day 2. The mature milk stage was reached by day 7. The galactose metabolism and tyrosine metabolism were uprated after day 3 of lactation. Full article
(This article belongs to the Special Issue Animal Nutritional Metabolism and Toxicosis Disease)
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18 pages, 7169 KiB  
Article
miR-21/SMAD2 Is Involved in the Decrease in Progesterone Synthesis Caused by Lipopolysaccharide Exposure in Follicular Granulosa Cells of Laying Goose
by Xinyi Guo, Shijia Ying, Huiping Xiao, Hao An, Rihong Guo, Zichun Dai and Wenda Wu
Metabolites 2024, 14(7), 362; https://doi.org/10.3390/metabo14070362 - 27 Jun 2024
Viewed by 872
Abstract
Lipopolysaccharide (LPS) is one of the important pathogenic substances of E. coli and Salmonella, which causes injury to the reproductive system. Ovarian dysfunction due to Gram-negative bacterial infections is a major cause of reduced reproductive performance in geese. However, the specific molecular [...] Read more.
Lipopolysaccharide (LPS) is one of the important pathogenic substances of E. coli and Salmonella, which causes injury to the reproductive system. Ovarian dysfunction due to Gram-negative bacterial infections is a major cause of reduced reproductive performance in geese. However, the specific molecular mechanisms of LPS-induced impairment of sex steroid hormone synthesis have not been determined. The regulatory mechanism of miRNA has been proposed in many physiological and pathogenic mechanisms. Therefore, the role of miRNA in breeding geese exposed to LPS during the peak laying period was investigated. In this study, twenty Yangzhou geese at peak laying period were injected with LPS for 0 h, 24 h, and 36 h. The follicular granulosa layer was taken for RNA-seq and analyzed for differentially expressed miRNAs. It was observed that LPS changed the appearance of hierarchical follicles. miRNA sequencing analysis was applied, and miR-21 and SMAD2 (SMAD family member 2) were selected from 51 differentially expressed miRNAs through bioinformatics prediction. The results showed that miR-21 down-regulated SMAD2 expression and progesterone (P4) production in LPS-treated goose granulosa cells (GCs). It also determined that overexpression of miR-21 or silence of SMAD2 suppressed the sex steroid biosynthesis pathway by decreasing STAR and CYP11A1 expression. Down-regulation of miR-21 exacerbates the LPS-induced decline in P4 synthesis and vice versa. The findings indicated that miR-21 was involved in LPS regulation of P4 synthesis in goose granulosa cells by down-regulating SMAD2. This study provides theoretical support for the prevention of LPS-induced ovarian dysfunction in geese. Full article
(This article belongs to the Special Issue Animal Nutritional Metabolism and Toxicosis Disease)
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15 pages, 667 KiB  
Article
Effects of Increasing Glycerin Levels in Broiler Chickens
by Elaine de Assis Carvalho, Weslane Justina da Silva, Denise Russi Rodrigues, Ludmilla Faria dos Santos, Camila Ferreira Rezende, Flávio Medeiros Vieites, Fabiana Ramos dos Santos, Fabiano Guimarães Silva and Cibele Silva Minafra
Metabolites 2024, 14(6), 308; https://doi.org/10.3390/metabo14060308 - 28 May 2024
Viewed by 932
Abstract
Glycerin contributes to the animal’s energy metabolism as an important structural component of triglycerides and phospholipids. The present study was carried out to evaluate the effect of replacing corn with 0, 5, 10, and 15% of glycerin in terms of performance, digestibility, carcass [...] Read more.
Glycerin contributes to the animal’s energy metabolism as an important structural component of triglycerides and phospholipids. The present study was carried out to evaluate the effect of replacing corn with 0, 5, 10, and 15% of glycerin in terms of performance, digestibility, carcass yield, relative weights of gastrointestinal tract (GIT) organs, and nutrient metabolism. Four hundred chickens (40.0 g ± 0.05 g) were distributed in a completely randomized design with four treatments and five replicates. Growth parameters were measured at 7, 14, 21, and 42 days. Digestibility of crude protein and fat, carcass yield, relative weights of GIT organs, and biochemical blood profile were measured. The results were subject to an analysis of variance by Tukey’s HSD test (p > 0.05). The inclusion of 5%, 10%, or 15% of glycerin did not influence performance or affect the crude protein and fat digestibility in broilers (p > 0.05) when compared to that of the basal (0%) diet. Similarly, the supplementation of glycerin levels showed no significant influence (p > 0.05) on the relative GIT organ weights, carcass yield, or nutrient metabolism. Thus, we concluded that glycerin may be included in the broilers’ diets in rations of up to 15%. Full article
(This article belongs to the Special Issue Animal Nutritional Metabolism and Toxicosis Disease)
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