Advances in Postmortem Metabolomics and Forensic Toxicology

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 2480

Special Issue Editors


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Guest Editor
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden
Interests: biomarker discovery; untargeted metabolomics; proteomics; postmortem investigation; mass spectrometry

E-Mail Website
Guest Editor
1. Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
2. Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden
Interests: forensic toxicology; postmortem metabolomics; new psychoactive substances

E-Mail Website
Guest Editor
1. Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
2. Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden
Interests: forensic toxicology; clinical toxicology; postmortem toxicology; forensic medicine; psychopharmacology

Special Issue Information

Dear Colleagues,

Metabolomics and toxicology are two fields that have shown tremendous potential in understanding the postmortem processes that occur in the human body. Both fields have been instrumental in identifying the molecular signatures of postmortem processes, including the identification of specific metabolites and toxins that are associated with certain types of death.

The Special Issue on "Advances in Postmortem Metabolomics and Toxicology" aims to bring together experts from both fields to showcase the latest developments in the area. The focus of the Special Issue will be on the application of metabolomics and toxicology in postmortem investigations, including the use of these techniques in forensic toxicology, autopsy analysis, and cause and time of death investigations. Research addressing new and developing methodologies is also encouraged.

The scope of the Special Issue will include, but is not limited to, the identification and quantification of metabolites and toxins in postmortem samples, the use of metabolomics and toxicology in determining the cause and time of death, and the development of new analytical methods for the analysis of postmortem samples.

The purpose of the Special Issue is to provide a platform for researchers to share their latest findings and to promote the use of metabolomics and toxicology in postmortem investigations. The issue will also highlight the potential applications of these techniques in improving the accuracy and efficiency of forensic investigations. The Special Issue series will be of interest to researchers in the fields of metabolomics, toxicology, forensic science, and pathology, as well as to other scientists interested in the analysis of postmortem samples.

Dr. Liam J. Ward
Prof. Henrik Green
Dr. Fredrik C. Kugelberg
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • metabolic profiling
  • biomarkers
  • forensic toxicology
  • clinical toxicology
  • forensic medicine
  • postmortem interval
  • cause of death

Published Papers (1 paper)

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Research

13 pages, 2452 KiB  
Article
Postmortem Alteration of Purine Metabolism in Coronary Artery Disease
by Phakchira Somtua, Churdsak Jaikang, Giatgong Konguthaithip, Kanicnan Intui, Somlada Watcharakhom, Timothy E. O’Brien and Yutti Amornlertwatana
Metabolites 2023, 13(11), 1135; https://doi.org/10.3390/metabo13111135 - 8 Nov 2023
Viewed by 1605
Abstract
A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this [...] Read more.
A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this pathway in postmortem changes needs to be explored. This study investigated the levels of blood purine metabolites in CAD after death. Heart blood samples (n = 60) were collected and divided into CAD (n = 23) and control groups (n = 37). Purine metabolites were measured via proton nuclear magnetic resonance. Guanosine triphosphate (GTP), nicotinamide adenine dinucleotide (NAD), and xanthine levels significantly decreased (p < 0.05); conversely, adenine and deoxyribose 5-phosphate levels significantly increased (p < 0.05) in the CAD group compared to the control group. Decreasing xanthine levels may serve as a marker for predicting the cause of death in CAD (AUC = 0.7). Our findings suggest that the purine pathway was interrupted by physiological processes after death, causing the metabolism of the deceased to differ from that of the living. Additionally, xanthine levels should be studied further to better understand their relationship with CAD and used as a biomarker for CAD diagnosis under decomposition and skeletonization settings. Full article
(This article belongs to the Special Issue Advances in Postmortem Metabolomics and Forensic Toxicology)
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