Cardiometabolic Health and Disease in Women: Metabolites and Metabolic Biomarkers

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 2661

Special Issue Editors


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Guest Editor
1. Swiss Paraplegic Research, 6207 Nottwil, Switzerland
2. Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
Interests: women's health; cardiovascular diseases; type 2 diabetes; spinal cord injury; clinical epidemiology

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Assistant Guest Editor
1. Swiss Paraplegic Research, 6207 Nottwil, Switzerland
2. Institute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland
Interests: women’s health; cardiovascular diseases; spinal cord injury

Special Issue Information

Dear Colleagues,

Sex differences are described in nearly all human diseases, influencing their prevalence, severity, and prognosis. Cardiometabolic diseases (CMDs) have been taken as a classic example of sexual dimorphism in human diseases. Women are considered to be protected from CMD before menopause. However, this sex advantage for women gradually disappears with increased age, and is associated with reduced estrogen levels after menopause. In addition, other women-specific conditions such as gestational diabetes, preeclampsia and age at menarche have been identified as important determinants of cardiometabolic risk in women throughout the lifespan. Despite the emerging need for tailored women-specific prevention and intervention strategies, our knowledge of sex- and gender-specific markers of CMD remains limited. Metabolomics, the pivotal tool for biomarker discovery, can help us disentangle the underlying mechanisms of disease onset and guide development of women-specific diagnostic and prognostic CMD markers.

This Special Issue, entitled “Cardiometabolic Health and Disease in Women: Metabolites and Metabolic Biomarkers”, highlights the potential of metabolites to be used as biomarkers in clinical and epidemiological research focused on CMD in women. We seek manuscripts focused on understanding the role of women-specific risk factors in the development and prognosis of CMD, the discovery of novel diagnostic and prognostic biomarkers in CMD diseases, and the use of established biomarkers for new indications. In addition, studies focused on sex differences in CMD that contribute to our understanding of women-specific aspects of CMD are eligible. This Special Issue will publish high-quality original research articles (i.e., observational, interventional and experimental studies) and review articles engaging metabolomics approaches to study CMD in women.

Dr. Glisic Marija
Dr. Peter Francis Raguindin
Guest Editors

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Keywords

  • women's health
  • menopause
  • menarche
  • preeclampsia
  • gestational diabetes
  • sex differences
  • metabolomics
  • biomarkers

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Published Papers (1 paper)

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12 pages, 433 KiB  
Study Protocol
Dietary Patterns, Metabolomic Profile, and Nutritype Signatures Associated with Type 2 Diabetes in Women with Postgestational Diabetes Mellitus: MyNutritype Study Protocol
by Farah Yasmin Hasbullah, Barakatun-Nisak Mohd Yusof, Rohana Abdul Ghani, Zulfitri ’Azuan Mat Daud, Geeta Appannah, Faridah Abas, Nurul Husna Shafie, Hannah Izzati Mohamed Khir and Helen R. Murphy
Metabolites 2022, 12(9), 843; https://doi.org/10.3390/metabo12090843 - 7 Sep 2022
Cited by 6 | Viewed by 2138
Abstract
Women with previous gestational diabetes mellitus (post-GDM) have an increased risk of cardiometabolic diseases including type 2 diabetes (T2D). Current diabetes screening is based on the oral glucose tolerance test without nutritional assessments, even though unhealthy dietary patterns were found to expedite disease [...] Read more.
Women with previous gestational diabetes mellitus (post-GDM) have an increased risk of cardiometabolic diseases including type 2 diabetes (T2D). Current diabetes screening is based on the oral glucose tolerance test without nutritional assessments, even though unhealthy dietary patterns were found to expedite disease progression in women post-GDM. While a healthful dietary pattern reduces T2D risk, limited data support a dietary pattern tailored to the Asian population, especially in the Malaysian context. Metabolomic profiles associated with dietary patterns in this population are also lacking. The proposed study aims to investigate both components of dietary patterns and metabolomic profile, known as nutritype signatures, and their association with T2D in women post-GDM. The comparative cross-sectional study will involve a minimum of 126 Malaysian women post-GDM aged 18–49 years. Dietary patterns will be analysed using principal component analysis. Plasma and urinary metabolites will be quantified using one-dimensional proton nuclear magnetic resonance (1H NMR) spectroscopy. The aim of the study is identifying the nutritype signatures associated with T2D. The findings will support the development of early prevention measures against T2D in women post-GDM. Full article
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