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Metabolites
Special Issues
Metabolic Changes and Epigenetic Alterations
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Metabolic Changes and Epigenetic Alterations

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5777

Special Issue Editors

Dr. Francesco Spallotta

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Guest Editor
Biology and Biotechnology Department “Charles Darwin”, Sapienza University of Rome, 00185 Rome, Italy
Interests: epigenetics; metabolism; type 2 diabetes; gastrointestinal tumors; obesity
Dr. Barbara Illi

E-Mail Website
Guest Editor
Institute of Molecular Biology and Pathology - National Research Council (IBPM-CNR), Department of Biology and Biotecnology, Sapienza University of Rome, 00185 Roma, Italy
Interests: epigenetics; stem cells (including cancer stem cells); gene expression; molecular mechanisms of tumorigenesis; transcription factors; chromatin remodelling enzymes; post-translational modifications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The link between metabolism and epigenetics has been established for many years. Remarkably, it has been demonstrated that metabolites might work as a cofactor of specific epigenetic enzymes regulating their function and, consequently, cell transcriptomic landscape. Of note, metabolic rewiring and alterations are typical of different pathophysiological conditions including aging, cancer, chronic, and degenerative diseases. These epi-metabolite fluctuations affecting the cell epigenome might contribute to the onset and progression of the above-mentioned pathophysiological conditions. In this light, the discovery of the so-called “nuclear metabolic niches” confirmed the strict physical interaction between mitochondria, the main source of metabolites, and nuclei where the epi-metabolic exchange occurs. There, metabolic enzymes directly provide metabolites to epigenetic enzymes located at the chromatin. Moreover, recent advances in OMIC technologies and integrative analysis have helped to shed light on a set of novel epi-metabolic interactions underlying human diseases. The present issue has been designed with the goal to collect recent and original data pointing out the special link between metabolism and epigenetics in different pathophysiological contexts.

Dr. Francesco Spallotta
Dr. Barbara Illi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • epigenetic enzymes
  • metabolic syndrome
  • cancer
  • aging
  • metabolic rewiring
  • chronic diseases
  • chromatin

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Published Papers (2 papers)

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Research

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12 pages, 2045 KiB  
Article
H3 Lysine 4 Methylation Is Required for Full Activation of Genes Involved in α-Ketoglutarate Availability in the Nucleus of Yeast Cells after Diauxic Shift
by Elena Di Nisio, Svetlana Danovska, Livia Condemi, Angela Cirigliano, Teresa Rinaldi, Valerio Licursi and Rodolfo Negri
Metabolites 2023, 13(4), 507; https://doi.org/10.3390/metabo13040507 - 31 Mar 2023
Cited by 1 | Viewed by 1812
Abstract
We show that in S. cerevisiae the metabolic diauxic shift is associated with a H3 lysine 4 tri-methylation (H3K4me3) increase which involves a significant fraction of transcriptionally induced genes which are required for the metabolic changes, suggesting a role for histone methylation in [...] Read more.
We show that in S. cerevisiae the metabolic diauxic shift is associated with a H3 lysine 4 tri-methylation (H3K4me3) increase which involves a significant fraction of transcriptionally induced genes which are required for the metabolic changes, suggesting a role for histone methylation in their transcriptional regulation. We show that histone H3K4me3 around the start site correlates with transcriptional induction in some of these genes. Among the methylation-induced genes are IDP2 and ODC1, which regulate the nuclear availability of α-ketoglutarate, which, as a cofactor for Jhd2 demethylase, regulates H3K4 tri-methylation. We propose that this feedback circuit could be used to regulate the nuclear α-ketoglutarate pool concentration. We also show that yeast cells adapt to the absence of Jhd2 by decreasing Set1 methylation activity. Full article
(This article belongs to the Special Issue Metabolic Changes and Epigenetic Alterations)
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Review

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25 pages, 1506 KiB  
Review
Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism
by Xu Li, Pingdong Cai, Xinyuan Tang, Yingzi Wu, Yue Zhang and Xianglu Rong
Metabolites 2024, 14(4), 217; https://doi.org/10.3390/metabo14040217 - 12 Apr 2024
Cited by 1 | Viewed by 3025
Abstract
Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, pro-thrombotic, [...] Read more.
Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, pro-thrombotic, and inflammatory health hazards. Due to their complex pathological mechanisms, there is a lack of effective diagnostic and treatment methods for cardiac metabolic disorders. Lactylation is a type of post-translational modification (PTM) that plays a regulatory role in various cellular physiological processes by inducing changes in the spatial conformation of proteins. Numerous studies have reported that lactylation modification plays a crucial role in post-translational modifications and is closely related to cardiac metabolic diseases. This article discusses the molecular biology of lactylation modifications and outlines the roles and mechanisms of lactylation modifications in cardiometabolic disorders, offering valuable insights for the diagnosis and treatment of such conditions. Full article
(This article belongs to the Special Issue Metabolic Changes and Epigenetic Alterations)
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