Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 890
Special Issue Editor
2. Clinic of Diabetes, Nutrition and Metabolic Diseases, Emergency County Hospital, 200642 Craiova, Romania
Interests: metabolic diseases epidemiology; biochemical and molecular biomarkers of obesity and diabetes; entero-insular axis; insulinresistance; obesity cardio-metabolic phenotypes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases represent a major challenge and a public health problem worldwide, obesity and type 2 diabetes being the most prevalent metabolic disorders causing serious short- and long-term adverse health outcomes and comorbidities.
In recent years, two atypical phenotypes of obesity have been described - metabolically healthy obesity, which is not associated with insulin resistance or cardiometabolic profile characteristic of obesity, and metabolically unhealthy normal weight, characterized by the presence of insulin resistance in normal weight individuals.
However, despite the high prevalence of obesity, atypical obesity phenotypes, and type 2 diabetes, the exact etiology is poorly understood, and there is still debate regarding the molecular pathways and metabolic signature, the diagnostic threshold to apply for identification of the cardiometabolic phenotypes of obesity, and the optimal therapeutic strategies.
In recent years, new biochemical and molecular biomarkers, including genetic variants, DNA methylation, specific miRNAs, microbiota, microbial metabolites, mitochondrial dysfunction, adipocytokines, metabolomic profiles, the entero-insular axis, and the neuro-adipocyte axis, have garnered significant interest in the diagnosis and prognosis of the metabolic triad.
This Special Issue will be dedicated to the impact of microbiota, genetic, epigenetic and neuro-endocrino-metabolic factors on pathogenesis and diagnosis of the obesity, insulin resistance and type 2 diabetes triad, welcoming all those studies that will help to identify future diagnostic approaches for the detection of obesity cardiometabolic phenotypes and evaluate personalized and effective nutrition and pharmacological strategies for prevention and management of metabolic triad.
Dr. Simona Georgiana Popa
Guest Editor
Manuscript Submission Information
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Keywords
- cardiometabolic phenotypes of obesity
- metabolomic profiles
- microbiota
- entero-insular axis
- adipocytokines
- precision therapy
- insulin resistance
- type 2 diabetes
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