Fatty Acid Metabolism

Dear Colleagues,

The capability of the organism to respond or adapt metabolism to substrate availability, modulating its storage, trafficking, and utilization is called metabolic flexibility. An example is the ability to select fuels between glucose and fatty acids. Insulin resistance leads to metabolic inflexibility in type 2 diabetes and obesity. Metabolic flexibility also relays on organs’ interplay since the liver, adipose tissue, and muscle regulate energy homeostasis in a coordinated fashion depending on the caloric intake and energy demand. Metabolic inflexibility and the associated alterations in the metabolism of fatty acids are related to a variety of pathologies, such as an accumulation of triglycerides within hepatocytes, leading to a clinical condition known as nonalcoholic fatty liver disease, changes in the lipid composition or in the regulation of noncoding RNAs related to lipid metabolism in cancer cells. This Special Issue highlights the importance of the metabolism of fatty acids in health and disease. Specific areas include: metabolic flexibility and fatty acid metabolism, fuel supply and muscle adaptation during the life span and metabolic integration of fatty acid metabolism and disease, including situations such as catch up growth, nonalcoholic fatty acid liver disease, diabetes, obesity, cancer or inflammation. Manuscripts dealing with other pertinent challenging issues are also highly desired.

Prof. Dr. Maria D. Giron-Gonzalez
Dr. Jose M. López-Pedrosa
Prof. Dr. Rafael Salto-Gonzalez
Guest Editors

Manuscript Submission Information

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