Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 1 July 2025 | Viewed by 2
Special Issue Editors
Interests: precision medicine; metabolomics; autoimmune diseases; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although clinical chemistry analyses such as fasting plasma glucose, cholesterol, triglycerides, and the components of the basic and complete metabolic panels serve as the backbone for preliminary patient analyses, the development of more advanced tests means that they are beginning to be used to diagnose patients. Currently, standard assays such as the lipid panel which provides high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, and cholesterol levels provide an overall assessment of the potential presence of a disease linked to lipid metabolism in patients. Metabolomics can provide additional information regarding a greater number of molecules and the speciation of molecules, which can provide additional insight into the presence of disease by identifying biochemical trajectories earlier in the disease onset process and providing additional insight into the presence of a specific disease. For example, metabolomics and lipidomic signatures not only provide cholesterol levels but also information on bile acids, free fatty acids, acylcarnitines, ketone bodies, sterols, steroid hormones, and higher-molecular-weight lipid species such as mono-, di-, and triacylglycerols, cholesterol esters, sphingolipids, and others. This more comprehensive assessment from a single, low-volume sample can provide insight into multiple different disease mechanisms and these same molecules can be leveraged to characterize therapeutic (medicinal and nutritional) interventions once patients are diagnosed and treated. Metabolomics can be applied to cardiometabolic diseases, hormonal dysfunction (e.g. thyroid diseases), neurological diseases, autoimmune diseases, diseases of the digestive system, and others. A patient’s metabolomic profile is not just driven by their genotype, but also by their nutritional intake and environmental and lifestyle choices. Understanding the implications of each of these contributors is of central importance to understanding a patient’s phenotype, not only to monitor human health but also to identify new biomarkers of disease and to monitor therapeutic interventions for those diseases.
This Special Issue of Metabolites entitled “Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications” will be dedicated to identifying and addressing the most current challenges and successes in utilizing metabolomics independently or alongside other ‘omics’ technologies for diagnosing diseases and following patients post intervention to treat their disease. In addition to clinical studies, basic research including animal models and cell culture studies will also be included to provide a robust picture of the latest results in the field. New bioinformatics approaches for data analysis and tools to analyze large data sets are of interest and will also be considered for this Special Issue.
Dr. Adam D. Kennedy
Dr. Greg Michelotti
Guest Editors
Manuscript Submission Information
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Keywords
- metabolomics
- precision medicine
- clinical disease
- biomarkers
- therapeutics
- clinical metabolomics
- nutrition
- functional medicine
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