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The Metabolic Adaptations in Non-pharmacological Interventions

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Special Issue Editor

Prof. Dr. Benoit Dugué

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Guest Editor

Laboratory MOVE (EA 6314), Faculty of Sport Sciences, University of Poitiers, 8 allée Jean Monnet, 86000 Poitiers, France
Interests: physical exercise; exercise testing; exercise; cold stress; physical activity; rehabilitation; muscle; training; exercise physiology; stress physiology; hematocrit; blood cells; blood; endothelial function; serum; chronic heart failure; exercise science; sports science; exercise performance; cardiovascular system
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Special Issue Information

Dear Colleagues,

Non-pharmacological interventions (e.g., nutrition, physical exercise, and physiotherapy) are used to address risk factors in the prevention of diseases and enable rehabilitation when health problems occur. Such interventions are currently key components in health care programs in prevention and rehabilitation. However, there is still much to learn in terms of how to improve such interventions and with respect to understanding significant and fine metabolic changes that occur in patients when interventions are in use.

New technologies such as metabonomics/metabolomics should play a role for better understanding human adaptations during and after an intervention, pinpoint important metabolic adaptations that are, for the time being, unknown, help in designing precise and customized interventions, and even foreseek the success of interventions.

This Special Issue of Metabolites will be dedicated to publishing original articles and reviews that focus on the metabolic characteristics linked to specific clinical situations that can be modified in response to non-pharmacological interventions in the context of prevention and rehabilitation. Manuscripts that address adaptation differences in sex and aging will be of particular interest.

Prof. Dr. Benoit Dugué
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Research

21 pages, 2562 KiB

Open AccessArticle

Serum Metabolome Adaptations Following 12 Weeks of High-Intensity Interval Training or Moderate-Intensity Continuous Training in Obese Older Adults

by Layale Youssef, Mélanie Bourgin, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Maria Chiara Maiuri, Vincent Marcangeli, Maude Dulac, Guy Hajj-Boutros, Fanny Buckinx, Eva Peyrusqué, Pierrette Gaudreau, José A. Morais, Gilles Gouspillou, Guido Kroemer, Mylène Aubertin-Leheudre and Philippe Noirez

Metabolites 2023, 13(2), 198; https://doi.org/10.3390/metabo13020198 - 29 Jan 2023

Cited by 1 | Viewed by 2331

Abstract

Physical activity can be effective in preventing some of the adverse effects of aging on health. High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) are beneficial interventions for the quality of life of obese older individuals. The understanding of all possible metabolic mechanisms underlying these beneficial changes has not yet been established. The aim of this study was to analyze changes in the serum metabolome after 12 weeks of HIIT and MICT in obese older adults. Thirty-eight participants performed either HIIT (n = 26) or MICT (n = 12) three times per week for 12 weeks. Serum metabolites as well as clinical and biological parameters were assessed before and after the 12-week intervention. Among the 364 metabolites and ratio of metabolites identified, 51 metabolites changed significantly following the 12-week intervention. Out of them, 21 significantly changed following HIIT intervention and 18 significantly changed following MICT. Associations with clinical and biological adaptations revealed that changes in acyl-alkyl-phosphatidylcholine (PCae) (22:1) correlated positively with changes in handgrip strength in the HIIT group (r = 0.52, p < 0.01). A negative correlation was also observed between 2-oxoglutaric acid and HOMA-IR (r = −0.44, p < 0.01) when considering both groups together (HIIT and MICT). This metabolite also correlated positively with quantitative insulin-sensitivity check index (QUICKI) in both groups together (r = 0.46, p < 0.01) and the HIIT group (r = 0.51, p < 0.01). Additionally, in the MICT group, fumaric acid was positively correlated with triglyceride levels (r = 0.73, p < 0.01) and acetylcarnitine correlated positively with low-density lipoprotein (LDL) cholesterol (r = 0.81, p < 0.01). These four metabolites might represent potential metabolites of interest concerning muscle strength, glycemic parameters, as well as lipid profile parameters, and hence, for a potential healthy aging. Future studies are needed to confirm the association between these metabolites and a healthy aging. Full article

(This article belongs to the Special Issue The Metabolic Adaptations in Non-pharmacological Interventions)

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23 pages, 9473 KiB

Open AccessArticle

¹H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling—A Preliminary Investigation

by Wafa Douzi, Delphine Bon, Sara Suikkanen, Paula Soukkio, Nadège Boildieu, Arja Nenonen, Markku Hupli, Katriina Kukkonen-Harjula and Benoit Dugué

Metabolites 2022, 12(8), 744; https://doi.org/10.3390/metabo12080744 - 12 Aug 2022

Cited by 1 | Viewed by 2589

Abstract

In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with ¹H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events. Full article

(This article belongs to the Special Issue The Metabolic Adaptations in Non-pharmacological Interventions)

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