Metabolic Reprogramming: Implications in Cancer, Immune Surveillance and Regenerative Medicine
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 10393
Special Issue Editors
Interests: metabolites profiling of tumor interstitial fluid; immune response; T-lymphocytes; dendritic cells; signal transduction; phagocytosis; antigen presentation; NF-kappaB pathway
Special Issues, Collections and Topics in MDPI journals
Interests: clinical biochemistry; leukemia and lymphoma; molecular biomarkers; immunotherapy; T- and B-cell biology
Special Issues, Collections and Topics in MDPI journals
Interests: endoplasmic reticulum (ER) stress response; analysis of the dynamics of transport in the early secretory pathway; mechanisms regulating autophagosome biogenesis; role of autophagy in neurodegenerative and infectious diseases; role of autophagy in cell growth control and unconventional secretion; pharmacological modulation of autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic reprogramming is a switch in metabolism that cells adopt to support an increased proliferative capacity or to undertake a specific differentiation pathway, and the most paradigmatic examples of these are cancer cells and stem cells, respectively.
Cancer cells show distinct metabolic phenotypes in order to cope with the energetic and metabolic demands required to support tumor growth and progression. Immune cells, including T-lymphocytes, natural killer cells, and macrophages, play a key role in providing broad spectrum protection that serves to eradicate cancerous cells. However, the abnormal metabolic activities of cancer cells influence the nutrient states of the tumor microenvironment (e.g., glucose, glutamine, lactate, and tryptophan-related metabolites such as kynurenine) and limit the antitumoral activity of immune cells. Indeed, tumors escape immunity by inducing metabolic switches in immune cells which lead to immune dysfunction characterized by attenuated tumoricidal effector functions of TILs, such as a minor IFNγ production and cytotoxicity.
Metabolic reprogramming also plays a fundamental role in the regulation of cell fate, and specific metabolic switches occur during the transitions between different pluripotent states as well as during the generation of induced pluripotent stem cells (iPSCs) through somatic reprogramming. Moreover, recent evidence shows that metabolic reprogramming and specific metabolites drive the differentiation pathways of hematopoietic and skeletal muscle tissue stem cells, with fundamental implications for regenerative medicine.
For this Special Issue, we invite research or review articles on metabolic reprogramming of cancer and immune cells as well as stem cells and somatic cells which acquire pluripotency.
Prof. Giuseppe Fiume
Prof. Camillo Palmieri
Prof. Maurizio Renna
Prof. Massimo D’Agostino
Guest Editors
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Keywords
- metabolic reprogramming
- cancer cell metabolism
- tumor microenvironment
- immunometabolism
- tumor-infiltrating lymphocytes
- macrophages
- NK cells
- exhaustion
- stem cells
- pluripotent stem cells
- induced pluripotent stem cells (iPSCs)
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