The Role of Metabolism in Brain Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (30 October 2020) | Viewed by 8977
Special Issue Editors
Interests: CNS diseases; metabolism; immunology; microbiota; metabolites
Special Issue Information
Dear Colleagues,
Brain diseases, specifically Alzheimer’s, Parkinson’s, Huntington’s, amylotrophic lateral sclerosis, and multiple sclerosis, constitute an area of medicine that has been standing still with respect to the development of treatments. Medicine has been developed for some of the aforementioned diseases with only symptomatic efficacy.
Lately, progress from different sides has been made, and we have shown that a metabolic shift seems to be a key event in disease induction and progression; others have shown that there is a correlation with microbiota in the gut, oral and nasal cavity, and lungs. Again, others have shown that diet and vitamins have an effect on such diseases.
The suggestion is, therefore, that CNS diseases are affected by the interplay between microbiota, metabolites, diet, and genetics. One influences the others, and vice versa. In other words, one has to see these different processes as part of a system in which, in the end, the balance or imbalance between the different processes is the driver to become healthy or diseased. This systemic way of looking at CNS diseases opens up the potential for personalized treatment, including new therapeutics and diagnosis parameters.
Prof. John Dirk Vestergaard Nieland
Prof. Angeliques Corthals
Guest Editor
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Keywords
- CNS disease
- Metabolites
- Microbiota
- Genetics
- Diet
- Immune system
- Systemic approach
- Autoimmunity
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